The collective tone conveys that the study challenges conventional use of hydrochlorothiazide for kidney stone prevention, with words like 'little efficacy' and 'not effective' highlighting a dismissive tone, while some comments express surprise about the results, illustrating a slight shift in the perceived impact of the medication in clinical practice.
AgreementLow agreement
Most discussions acknowledge that the study found hydrochlorothiazide ineffective for preventing recurrent kidney stones, reflecting a consensus that the evidence challenges previous beliefs about its benefits.
InterestModerate interest
The discussions show moderate curiosity, with some participants questioning current practices, but overall, the focus remains on the study's implications rather than deep exploration or enthusiasm.
EngagementLow engagement
Many discussions are brief, referencing the study or summarizing outcomes without extensive analysis, indicating a relatively low level of deep engagement with the intricacies of the research.
ImpactLow impact
Given the multiple mentions of practice change and guideline reconsideration, but without significant controversy or alternative perspectives, the perceived impact appears modest.
Abstract in brief
The study tested whether different doses of hydrochlorothiazide (125 mg, 25 mg, 50 mg) could prevent the recurrence of calcium kidney stones compared to a placebo, but found no clear dose-response relationship, meaning higher doses didn't necessarily lead to fewer recurrences.
Overall, the recurrence rates were similar across groups, with around 56-59% experiencing recurrence regardless of whether they took hydrochlorothiazide or placebo.
Patients on hydrochlorothiazide had higher rates of side effects like hypokalemia, gout, new-onset diabetes, skin allergies, and increased plasma creatinine levels, but these risks didn't translate into a significant reduction in stone recurrence.]
Research Summary: Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence
https://t.co/9MNRQaX90o https://t.co/Om2u8GPSNl
Mar 3, 2023 · 152 likes · 55 shares · 934,187 followersView post →
AU
Ashley Winter MD || Urologist
@AshleyGWinter · X
Hey urology twitter - are y'all dropping HCTZ from your practice? Are the guidelines changing? Did I miss the discussion?
https://t.co/gROUgqPQKf
Mar 27, 2023 · 50 likes · 153,106 followersView post →
KM
Kidney Medicine
@KidneyMed · X
Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial
https://t.co/nt15Fg3gV4 https://t.co/GC3Rq7pBPM
Oct 16, 2023 · 39 likes · 18 shares · 10,049 followersView post →
May 1, 2023 · 20 likes · 5 shares · 1,372 followersView post →
UG
Urologeman (Nariman Gadzhiev)
@Urologeman · X
Mar 7, 2023 · 15 likes · 7 shares · 5,432 followersView post →
NC
Nephrology Journal Club
@NephJC · X
Do you live in the Stone Belt ?
How often do you encounter a recurrent kidney stone former?
Join us tonight at 9 PM IST for the second chat of #nephJC on the NO STONE trial .
NEPHROCIOUS (POD 4) NSMC 2023 is excited to host you
https://t.co/ROW1EyZa20 #NephJC https://t.co/J3QybzoTtX
Prof Daniel Fuster and PrivDoz Sven Trelle discuss evidence-based therapies for secondary prevention of calcium-based kidney stones, highlighting the NOSTONE study on hydrochlorothiazide return prevention and dietary…
This video discusses current trends in prostate cancer screening, including the effectiveness of PSA testing and new technologies. It also covers the latest research on preventing kidney-stone recurrence with…
@paulelarzy @Topiramatee Le niveau de preuve est pas genialissime (dernier RCT que j'ai en tête : https://t.co/9uv2D9odYa), les thiazidiques font pisser du sodium (pas bon pour la maladie lithiasique), exposent à toutes les toxicités de ces médicaments...
Sep 12, 2025 · 1 like · 2,922 followersView post →
秀佳
秀秀-点我头像~佳我
@SusanSudio · X
@MartyMakary would LOVE your take on this study (I’m reading Blind Spots now). I challenged my urologist with the results since I’ve been taking HCTZ for years. The practice won’t budge… but of course I can do what I want
Jun 6, 2024 · 1 like · 2 shares · 2,624 followersView post →
GH
Gunnar Henrik Heine
@gunnar_heine · X
@HeerspinkHiddo @DavidCWheeler2 @EWijkmark @MagnusAstrand @GreaserPete @BradRovin @IgAN_JBarratt 4: NOSTONE from Nasser A. Dhayat, Sven Trulle and @Dan_Fuster from the @inselgruppe
@unibern Detailed talk at https://t.co/dqhrEEbxN3 (
Dec 22, 2023 · 2 likes · 2,422 followersView post →
HT
@Heart_Team
@Heart_Team1 · X
RT @georgepapadapol: Hidrocloritiazida (HCT) y recurrencia) de cálculos renales
No se encontró relación entre las dosis de HCT y recurrenci…
Hidrocloritiazida (HCT) y recurrencia) de cálculos renales
No se encontró relación entre las dosis de HCT y recurrencia sintomática/radiológica de cálculos, pero hubo exceso de eventos adversos (diabetes mellitus de novo, hipokalemia, Gota y alergia)
Dec 16, 2023 · 1 like · 1 share · 1,256 followersView post →
MM
Marc Soco, MD
@msocoMD · X
RT @uppghnephrology:
Nov 22, 2023 · 1 share · 1,674 followersView post →
UN
UP-PGH Nephrology
@uppghnephrology · X
Nov 21, 2023 · 8 likes · 1 share · 216 followersView post →
JN
joanava_nefro
@joanava_nefro · X
RT @ralcazara: Siempre nos quedará el agua......La hidroclorotiazida no reduce la recurrencia de litiasis renal. En @NEJM https://t.co/todN…
Nov 15, 2023 · 24 shares · 712 followersView post →
D
diacavan
@diacavan · X
RT @ralcazara: Siempre nos quedará el agua......La hidroclorotiazida no reduce la recurrencia de litiasis renal. En @NEJM https://t.co/todN…
Nov 15, 2023 · 24 shares · 167 followersView post →
JG
Jose Luis Górriz
@jlgorriz · X
RT @ralcazara: Siempre nos quedará el agua......La hidroclorotiazida no reduce la recurrencia de litiasis renal. En @NEJM https://t.co/todN…
Nov 15, 2023 · 24 shares · 8,670 followersView post →
JJ
Javi Juega
@JJuega · X
RT @ralcazara: Siempre nos quedará el agua......La hidroclorotiazida no reduce la recurrencia de litiasis renal. En @NEJM https://t.co/todN…
Nov 14, 2023 · 24 shares · 359 followersView post →
DD
Doc Dorin
@doriny27 · X
RT @KidneyMed: Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial
https://t.co/nt15F…
Oct 17, 2023 · 18 shares · 971 followersView post →
DN
Dr. Ronald Caraballo NEFROLOGO
@ronald_nefro · X
RT @KidneyMed: Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial
https://t.co/nt15F…
Oct 17, 2023 · 18 shares · 666 followersView post →
I
islandnephdoc
@drgerodias · X
RT @KidneyMed: Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial
https://t.co/nt15F…
Oct 16, 2023 · 18 shares · 65 followersView post →
HA
H. A. A.
@tondercath · X
RT @KidneyMed: Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial
https://t.co/nt15F…
Oct 16, 2023 · 18 shares · 223 followersView post →
DN
Dr. Isra - Nefro
@jo6rael · X
RT @KidneyMed: Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial
https://t.co/nt15F…
Oct 16, 2023 · 18 shares · 328 followersView post →
HF
Hector Madariaga, MD FASN
@HecmagsMD · X
RT @KidneyMed: Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial
https://t.co/nt15F…
Oct 16, 2023 · 18 shares · 5,003 followersView post →
LM
Lindo Mahlase
@Dr_Mahlase · X
RT @KidneyMed: Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial
https://t.co/nt15F…
Oct 16, 2023 · 18 shares · 533 followersView post →
DR
David Rosenthal
@adobefalls · X
RT @KidneyMed: Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial
https://t.co/nt15F…
Oct 16, 2023 · 18 shares · 260 followersView post →
WH
Wael Hussein
@Teknofiliac · X
RT @KidneyMed: Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial
https://t.co/nt15F…
Oct 16, 2023 · 18 shares · 841 followersView post →
EP
Edgard Pais
@Edgard_2015 · X
Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial - Kidney Medicine https://t.co/QiMuoZk731
RT @KidneyMed: Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial
https://t.co/nt15F…
Oct 16, 2023 · 18 shares · 785 followersView post →
D
diacavan
@diacavan · X
RT @KidneyMed: Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial
https://t.co/nt15F…
Oct 16, 2023 · 18 shares · 167 followersView post →
SR
S.Runprapan
@wwanderlusterr · X
RT @KidneyMed: Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial
https://t.co/nt15F…
Oct 16, 2023 · 18 shares · 50 followersView post →
FB
Florian Buchkremer
@swissnephro · X
RT @KidneyMed: Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial
https://t.co/nt15F…
Oct 16, 2023 · 18 shares · 2,413 followersView post →
MJ
Mihir Kumar Jha
@diwtarni · X
RT @KidneyMed: Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial
https://t.co/nt15F…
Oct 16, 2023 · 18 shares · 184 followersView post →
RP
Renz Michael Pasilan
@RenzPasilan · X
RT @KidneyMed: Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial
https://t.co/nt15F…
Oct 16, 2023 · 18 shares · 191 followersView post →
KM
Kidney Medicine
@KidneyMed · X
Hydrochlorothiazide and Prevention of Kidney Stone Recurrence: A #NephJC Editorial on the NOSTONE Trial
https://t.co/nt15Fg3gV4 https://t.co/GC3Rq7pBPM
Oct 16, 2023 · 39 likes · 18 shares · 10,049 followersView post →
A
Ana
@Ana_S4639 · X
RT @nsmithmd: Felt smart earlier today answering a @UWorldMedical question right about HCTZ and kidney stones. Then I saw this bad boy come…
Jun 19, 2023 · 5 likes · 3,515 followersView post →
NL
Noelia Lafuente
@NoeliaLafuenteA · X
RT @JonathanNefro: Con historia de >2 litiasis por calcio, 59% tuvo recurrencia en 3 años, la hidroclorotiazida en diferentes dosis, compar…
Jun 12, 2023 · 24 shares · 95 followersView post →
YE
YNP of ERA
@ynptweets · X
4/ The #NOSTONE trial was a Swiss multicenter RCT aimed to evaluate the efficacy of #hydrochlorothiazide (HCTZ) in preventing the recurrence of nephrolithiasis in high-risk patients.
https://t.co/uGwCao6EPs
Jun 11, 2023 · 1 like · 3,823 followersView post →
CB
CHOP Publication Bot
@chop_pubs · X
Ryan S Hsi:
Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence
https://t.co/kv7cTHaOSe
Thanks to Dr. Fong (2nd year fellow) for lively JC debate on thiazides for stones. Still room to use these meds it seems. Need to consieder pharmacokinetics of drugs and K balance!
Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence | NEJM https://t.co/eb55sQDT3m
May 8, 2023 · 6 likes · 1,558 followersView post →
DF
Daniel G. Fuster
@Dan_Fuster · X
https://t.co/GqVhhxFTHZ
Great discussion on kidney stone prevention and NOSTONE with Gunnar, Marcus and Sven !
Thank you Marcus@home for hosting us.
Ab morgen bei #MARKUSatHOMe:
STEINHARTE EVIDENZ zur Nephrolithiasis: Prof. Daniel Fuster und PD Sven Trelle von der
@inselgruppe @unibern
Rezidiv-Prävention der Nephrolithiasis - NOSTONE - https://t.co/utpiS5qOXX via
@YouTube
mit
@MarcusSaemann @oegnephro @dgfn_ev @com_SFNDT
May 4, 2023 · 7 likes · 2 shares · 2,422 followersView post →
J
JorgeEdoChava75
@QicenoJorge · X
RT @NephJC: 2/10
What did I miss?
If someone has recurrent calcium stones we all know the drill - increase fluid intake, cut out NaCl, mod…
May 3, 2023 · 1 share · 1,004 followersView post →
NC
Nephrology Journal Club
@NephJC · X
2/10
What did I miss?
If someone has recurrent calcium stones we all know the drill - increase fluid intake, cut out NaCl, modify diet, add citrate, start a thiazide. Well, NOSTONE put that final piece of the algorithm to the test.
https://t.co/ROW1EyZa20
May 3, 2023 · 3 likes · 1 share · 38,574 followersView post →
Do you live in the Stone Belt ?
How often do you encounter a recurrent kidney stone former?
Join us tonight at 9 PM IST for the second chat of #nephJC on the NO STONE trial .
NEPHROCIOUS (POD 4) NSMC 2023 is excited to host you
https://t.co/ROW1EyZa20 #NephJC https://t.co/J3QybzoTtX
10/10
Final thoughts
✳️ Waitlist journey can be daunting as it is, our patients don’t need more impediments when aren't really necessary
➡️Up next, Rolling Stone's new hit Hydrochlorothiazide couldn't give any satisfaction in preventing kidney stones
https://t.co/ROW1EyZa20 https://t.co/zxpb3zta5P
Apr 5, 2023 · 1 like · 38,574 followersView post →
Hidroclorotiazida y prevención de la recurrencia de cálculos renales https://t.co/dVA4Xss3db
La incidencia de recurrencia no pareció diferir sustancialmente entre los pacientes que recibieron hidroclorotiazida 1 vez al día en dosis de 12,5 mg, 25 mg o 50 mg o placebo 1 vez al día
Mar 10, 2023 · 2 shares · 3,231 followersView post →
MK
Meg Kulkarni
@MiniMiniMeg · X
RT @RobCalvert18: NEJM study shows no benefits of giving thiazides to unselected recurrent calcium stone formers.
Perhaps targeting those…
Mar 10, 2023 · 1 share · 1,346 followersView post →
HU
High-Yield Urology
@HighYieldUro · X
Mar 10, 2023 · 8 likes · 1 share · 2,495 followersView post →
K
Kamol
@KamolMU · X
RT @vic_pallares: ⁉️#NOSTONEtrial, efficacy of thiazides in the prevention of the recurrence of kidney stones?⤵️
Mar 10, 2023 · 15 shares · 100 followersView post →
RC
Rob Calvert
@RobCalvert18 · X
NEJM study shows no benefits of giving thiazides to unselected recurrent calcium stone formers.
Perhaps targeting those with hypercalciuria refractory to dietary sodium correction might have revealed a statistically significant relative risk reduction.
https://t.co/OBS4dMT3Ab https://t.co/mWPgZqKzEh
Mar 10, 2023 · 10 likes · 1 share · 1,464 followersView post →
MH
Meloney Oliveira (She/Her)
@MeloneyOliveira · X
RT @NephRodby: NEJM says " the incidence of recurrence did not appear to differ substantially among pts receiving HCTZ... once daily. See #…
NEJM says " the incidence of recurrence did not appear to differ substantially among pts receiving HCTZ... once daily. See #ASNCommunities for excellent discussion https://t.co/sSl34sdU3b https://t.co/nJxJ82A9Jc
Mar 9, 2023 · 3 likes · 1 share · 16,035 followersView post →
Mar 8, 2023 · 7 shares · 8,818 followersView post →
SR
Sébastien Rubin
@SebastienRubin · X
Un petit échantillon mais un essai qui remet en question la place des thiazidiques dans le risque de récidive des calculs rénaux calciques :
pas d'efficacité et des effets indésirables dans ce travail.
Quel est l'avis des experts? @LucileFigueres
https://t.co/2mipu99rEC
Mar 8, 2023 · 3 likes · 1,809 followersView post →
FH
Felipe Figueiredo HoLEP
@FCAFigueiredo · X
RT @Urologeman:
Mar 8, 2023 · 7 shares · 6,789 followersView post →
TS
T. Emre Sener
@dremresener · X
RT @Urologeman:
Mar 7, 2023 · 7 shares · 1,671 followersView post →
Join @CoREndourology Virtual Journal Club to discuss the most recent @NEJM Thiazides and kidney stone prevention article #urology #KidneyDisease #endourology #UroSoMe
https://t.co/dm9cClBRPp https://t.co/4HH7Srb1Vl
Mar 6, 2023 · 7 likes · 3 shares · 1,854 followersView post →
P
pediatriaperu
@PediatriaPeru · X
RT @rincondesisifo: (NEJM) Seguridad y eficacia de la hidroclorotiazida en la prevención de recaídas en pac con litiasis renal https://t.co…
RCT | Hydrochlorothiazide is not effective for the prevention of kidney-stone recurrence – via @NEJM
https://t.co/quDLig4Yn0
Video summary: https://t.co/ulrBwzP8cK
Commentary: https://t.co/xtvFfdNqr5
Mar 6, 2023 · 1 like · 29,278 followersView post →
(NEJM) Seguridad y eficacia de la hidroclorotiazida en la prevención de recaídas en pac con litiasis renal https://t.co/PB0CbrhkOC ECA https://t.co/xEDhX2Or9m Vídeo resumen https://t.co/h0sVP4NeW1
Mar 6, 2023 · 2 likes · 1 share · 8,432 followersView post →
R
Ryuragnarok
@ryuragnarok · X
RT @DptMedecineCHUV: Une étude montre que le traitement préventif de récidive des calculs rénaux par hydrochlorothiazide est peu efficace.…
Une étude montre que le traitement préventif de récidive des calculs rénaux par hydrochlorothiazide est peu efficace.
Résultat d'une collaboration entre la #nephrologie et #urologie du CHUV et @inselgruppe, parue dans The New England Journal of Medicine: https://t.co/sq2TNkW7BJ https://t.co/8ny9bYA7ez
Mar 6, 2023 · 7 likes · 3 shares · 138 followersView post →
JJ
Joaquín San José
@jsanjosea · X
RT @alfonso_casi: En pacientes con cálculos renales recurrentes, la incidencia de recurrencia no pareció diferir sustancialmente entre los…
En pacientes con cálculos renales recurrentes, la incidencia de recurrencia no pareció diferir sustancialmente entre los pacientes que recibieron hidroclorotiazida una vez al día en dosis de 12,5 mg, 25 mg o 50 mg o placebo una vez al día.
https://t.co/t4FNDb6U6o
Mar 5, 2023 · 2 likes · 2 shares · 8,524 followersView post →
A
Alla
@Russ_AnaKoto8 · X
RT @NEJM: Research Summary: Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence
https://t.co/9MNRQaX90o https://t.co/Om2u8GPSNl
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