PubHawk
March 2023 PMID 36856616

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients.

Nicholas C Allen, Andrew J Martin, Victoria A Snaidr, Renee Eggins, Alvin H Chong, Pablo Fernandéz-Peñas, Douglas Gin, Shireen Sidhu, Vanessa L Paddon, Leith A Banney, Adrian Lim, Edward Upjohn, Helmut Schaider, Aparna D Ganhewa, Jennifer Nguyen

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Mentions

123
Peak: 69 in Mar 2023
across 6 sources since Mar 2023

Extended reach

3,445,512
potential audience

Total likes

177

Video views

1,011

Mentions per month

Mar 2023 – Oct 2024

Where it's discussed

  • X / Twitter74 posts
  • News39 articles
  • YouTube3 videos
  • Facebook3 posts
  • Blogs3 articles
  • Bluesky1 posts

AI synopsis

What people are saying

Several discussions around the publication point to the lack of efficacy of nicotinamide, using phrases like 'null result' and 'did not lead to lower numbers,' which illustrate disappointment. The critical tone and repeated emphasis on the study's shortcomings showcase a collective skepticism about the potential benefits of nicotinamide, which greatly influences the overall sentiment.

AgreementLow agreement

Many posts express skepticism about the effectiveness of nicotinamide for skin cancer prevention, indicating a lack of consensus on the findings.

InterestModerate interest

While some users show interest in the results, the tone is largely critical or dismissive, indicating limited intrigue.

EngagementNeutral engagement

Most discussions are superficial, with few engaging deeply with the research methodology or implications for practice.

ImpactLow impact

The overall sentiment indicates that contributors see the results as having minimal significance for future treatment or research.

Abstract in brief

  • Organ transplant recipients have a higher risk of skin cancer, and nicotinamide (vitamin B) is thought to help by repairing UV-induced DNA damage and reducing skin cancer incidence.
  • A phase 3 trial assigned participants with a history of keratinocyte cancers to receive either 500 mg of nicotinamide or a placebo daily for 12 months, monitoring for new skin lesions during this period.
  • Results showed no significant difference between the nicotinamide and placebo groups in the number of new keratinocyte cancers, suggesting that oral nicotinamide may not be effective in preventing skin cancer in organ transplant recipients.
Read the full abstract

Top posts

Most liked on X and Bluesky
NEJM
@NEJM · X

Research Summary: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/JjLlBvaKHr https://t.co/oA1bMgpegj

Mar 5, 2023 · 57 likes · 13 shares · 936,136 followers View post →
Top Biomedical Science
@imedverse · X

In this 12-month, placebo-controlled trial, oral nicotinamide therapy did not lead to lower numbers of keratinocyte cancers or actinic keratoses in immunosuppressed solid-organ transplant recipients. @NEJM #MedEd #MedTwitter https://t.co/IiZnp6GrhF https://t.co/ScUnnFHb34

Mar 6, 2023 · 25 likes · 6 shares · 90,379 followers View post →
Agingdoc
@agingdoc1 · X

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/6WIbTocKXR https://t.co/OMOIpG08pB

Mar 1, 2023 · 25 likes · 4 shares · 41,779 followers View post →
NEJM
@NEJM · X

In a placebo-controlled trial involving immunosuppressed organ-transplant recipients, oral nicotinamide (500 mg twice daily) for 12 months did not lead to lower numbers of keratinocyte cancers or actinic keratoses. https://t.co/JjLlBvaKHr https://t.co/v7E9yGOi49

Mar 3, 2023 · 23 likes · 8 shares · 936,136 followers View post →
Joel M. Topf, MD FACP
@kidney_boy · X

Vitamin B3 for the prevention of skin cancer in transplant patients? Nope. https://t.co/R1RCPHZcm0

Mar 8, 2023 · 11 likes · 5 shares · 63,334 followers View post →
Medical Xpress
@medical_xpress · X

Null result in #nicotinamide (vitamin B3) #skincancer trial of organ-transplant recipients @nejm https://t.co/BREeZM32Va https://t.co/lk59Q1ugFA

Mar 6, 2023 · 7 likes · 7 shares · 173,176 followers View post →

All mentions

BJD
@BrJDermatol · X

Nicotinamide for skin cancer chemoprevention in transplant recipients: a critically appraised topic https://t.co/QiGT1majer

Dec 18, 2023 · 4 likes · 1 share · 12,863 followers View post →
DrRPalmquist
@DrPalmquist · X

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/kemLxfg76f

Sep 6, 2023 · 3,166 followers View post →
ซันเล่าเรื่องผิว Sean Skin School
@DrSeanSkinSch · X

@LOrealParisTH #แชร์ได้ชัวร์ อ้างอิงแล้ว

Sep 4, 2023 · 13,265 followers View post →
Adela
@adelapoite · X

Nicotinamide for Skin Cancer Chemoprevention in Transplant Recipients | PracticeUpdate https://t.co/KRKl2ySEbv

Jun 13, 2023 · 1,247 followers View post →
ASDR-Dermatology Research
@AsdrResearch · X

Dr Nicholas Allen gave a fascinating talk on #Nicotinamide for skin cancer prevention in transplant recipients @DermatologyACD - 60% of this high risk group had not used sunscreen in one of the study weeks!

May 26, 2023 · 3 likes · 664 followers View post →
cancerscires
@cancerscires1 · X

#Nicotinamide for Skin-Cancer #Chemoprevention in Transplant #Recipients Clik here for more: https://t.co/XDV9RLdivg

Apr 1, 2023 · 2 followers View post →
Melanoma On My Mind
@Melanomaonmymin · X

Nicotinamide for Skin Cancer Chemoprevention in Transplant Recipients | comment: Sara Harcharik Perkins MD https://t.co/stolBGSk8a via @practiceupdate

Mar 22, 2023 · 1,143 followers View post →
cancerscires
@cancerscires1 · X

#Nicotinamide for Skin-Cancer #Chemoprevention in Transplant Recipients https://t.co/XDV9RLcKFI

Mar 15, 2023 · 2 followers View post →
Amit
@Amit62707383 · X

RT @NEJM: Research Summary: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/JjLlBvaKHr https://t.co/oA1b…

Mar 12, 2023 · 13 shares · 35 followers View post →
Skin Health Institute
@SkinHealth_Inst · X

Congratulations to A/Prof Alvin Chong, Dr Edward Upjohn and colleagues on having their paper ‘Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients’ published in The New England Journal of Medicine. Visit the link below https://t.co/6kha5sfx9V https://t.co/eBM1pHh7WE

Mar 10, 2023 · 1 like · 795 followers View post →
ARYAN®
@gladeolie · X

https://t.co/ak7EyrWgO8

Mar 10, 2023 · 1,503 followers View post →
Kenar Jhaveri
@kdjhaveri · X

RT @kidney_boy: Vitamin B3 for the prevention of skin cancer in transplant patients? Nope. https://t.co/R1RCPHZcm0

Mar 9, 2023 · 5 shares · 11,720 followers View post →
Diana Rodríguez Espinosa
@dianarodespi · X

RT @kidney_boy: Vitamin B3 for the prevention of skin cancer in transplant patients? Nope. https://t.co/R1RCPHZcm0

Mar 9, 2023 · 5 shares · 978 followers View post →
Nando Trujillo Cuellar
@nandoaimar · X

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients | NEJM https://t.co/hC1s6LBQin

Mar 8, 2023 · 296 followers View post →
Tired & Sakit
@tulunsokit · X

RT @kidney_boy: Vitamin B3 for the prevention of skin cancer in transplant patients? Nope. https://t.co/R1RCPHZcm0

Mar 8, 2023 · 5 shares · 3,729 followers View post →
Mneee3
@crafty8798 · X

RT @kidney_boy: Vitamin B3 for the prevention of skin cancer in transplant patients? Nope. https://t.co/R1RCPHZcm0

Mar 8, 2023 · 5 shares · 291 followers View post →
Edoardo Melilli
@EdoardoMelilli · X

RT @kidney_boy: Vitamin B3 for the prevention of skin cancer in transplant patients? Nope. https://t.co/R1RCPHZcm0

Mar 8, 2023 · 5 shares · 3,261 followers View post →
Joel M. Topf, MD FACP
@kidney_boy · X

Vitamin B3 for the prevention of skin cancer in transplant patients? Nope. https://t.co/R1RCPHZcm0

Mar 8, 2023 · 11 likes · 5 shares · 63,334 followers View post →
Joel Topf
@kidneyboy.bsky.social · Bluesky

Vitamin B3 for the prevention of skin cancer in transplant patients? Nope. https://www.nejm.org/doi/full/10.1056/NEJMoa2203086

Mar 8, 2023 View post →
Tina Kaczor, ND, FABNO
@naturopathiconc · X

How many authors does it take to publish a ssimple placebovs agent study on 158 participants? If it’s in NEJM, then climb aboard the authorship train! This study is crappy too: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/MKZFQiMxIk

Mar 7, 2023 · 1 like · 485 followers View post →
dermatologyf
@dermatologyf · X

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/yoOJNiYGOY

Mar 6, 2023 · 89 followers View post →
NHMRC CTC
@TrialsCentre · X

"Daily Treatment With Nicotinamide Does Not Reduce Risk Of Non-Melanoma Skin Cancer In Solid-Organ Transplant Recipients Who Have A History Of Skin Cancer." - in @NEJM

Mar 6, 2023 · 1 like · 1,787 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/vM28qzJarK

Mar 6, 2023 · 2,239 followers View post →
Tufail /
@Qabid_al_farooq · X

RT @imedverse: In this 12-month, placebo-controlled trial, oral nicotinamide therapy did not lead to lower numbers of keratinocyte cancers…

Mar 6, 2023 · 6 shares · 318 followers View post →
Ricardo bernal sanch
@Ricardobernals1 · X

RT @imedverse: In this 12-month, placebo-controlled trial, oral nicotinamide therapy did not lead to lower numbers of keratinocyte cancers…

Mar 6, 2023 · 6 shares · 189 followers View post →
edinssondp
@edinssondp · X

RT @imedverse: In this 12-month, placebo-controlled trial, oral nicotinamide therapy did not lead to lower numbers of keratinocyte cancers…

Mar 6, 2023 · 6 shares · 114 followers View post →
Manu Gupta
@guptam108 · X

RT @medical_xpress: Null result in #nicotinamide (vitamin B3) #skincancer trial of organ-transplant recipients @nejm https://t.co/BREeZM32V…

Mar 6, 2023 · 7 shares · 1,201 followers View post →
serrgv
@serrgv · X

RT @medical_xpress: Null result in #nicotinamide (vitamin B3) #skincancer trial of organ-transplant recipients @nejm https://t.co/BREeZM32V…

Mar 6, 2023 · 7 shares · 147 followers View post →
Bayar Jaff
@JaffBayar · X

RT @imedverse: In this 12-month, placebo-controlled trial, oral nicotinamide therapy did not lead to lower numbers of keratinocyte cancers…

Mar 6, 2023 · 6 shares · 605 followers View post →
Luisjvela@gmail.com
@Luisjvelagmail1 · X

RT @medical_xpress: Null result in #nicotinamide (vitamin B3) #skincancer trial of organ-transplant recipients @nejm https://t.co/BREeZM32V…

Mar 6, 2023 · 7 shares · 1,088 followers View post →
Dr. Thomas Mancinelli MD .·.
@thomasmmr · X

RT @imedverse: In this 12-month, placebo-controlled trial, oral nicotinamide therapy did not lead to lower numbers of keratinocyte cancers…

Mar 6, 2023 · 6 shares · 3,289 followers View post →
Science X
@sciencex_com · X

RT @medical_xpress: Null result in #nicotinamide (vitamin B3) #skincancer trial of organ-transplant recipients @nejm https://t.co/BREeZM32V…

Mar 6, 2023 · 7 shares · 3,531 followers View post →
Medical Xpress
@physorg_health · X

RT @medical_xpress: Null result in #nicotinamide (vitamin B3) #skincancer trial of organ-transplant recipients @nejm https://t.co/BREeZM32V…

Mar 6, 2023 · 7 shares · 7,100 followers View post →
Phys.org
@physorg_com · X

RT @medical_xpress: Null result in #nicotinamide (vitamin B3) #skincancer trial of organ-transplant recipients @nejm https://t.co/BREeZM32V…

Mar 6, 2023 · 7 shares · 1,024,252 followers View post →
Medical Xpress
@medical_xpress · X

Null result in #nicotinamide (vitamin B3) #skincancer trial of organ-transplant recipients @nejm https://t.co/BREeZM32Va https://t.co/lk59Q1ugFA

Mar 6, 2023 · 7 likes · 7 shares · 173,176 followers View post →
Fábio Fonseca
@FbioFon84085623 · X

RT @imedverse: In this 12-month, placebo-controlled trial, oral nicotinamide therapy did not lead to lower numbers of keratinocyte cancers…

Mar 6, 2023 · 6 shares · 585 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/0jO2fmYOS5

Mar 6, 2023 · 3,154 followers View post →
Top Biomedical Science
@imedverse · X

In this 12-month, placebo-controlled trial, oral nicotinamide therapy did not lead to lower numbers of keratinocyte cancers or actinic keratoses in immunosuppressed solid-organ transplant recipients. @NEJM #MedEd #MedTwitter https://t.co/IiZnp6GrhF https://t.co/ScUnnFHb34

Mar 6, 2023 · 25 likes · 6 shares · 90,379 followers View post →
soda_troubles,https://med-mastodon.com/@haysam
@set_fortess · X

RT @NEJM: Research Summary: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/JjLlBvaKHr https://t.co/oA1b…

Mar 5, 2023 · 13 shares · 2,550 followers View post →
Peaceful
@Gnar_mark · X

RT @NEJM: Research Summary: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/JjLlBvaKHr https://t.co/oA1b…

Mar 5, 2023 · 13 shares · 136 followers View post →
Drug Facts
@RX_facts · X

RT @NEJM: Research Summary: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/JjLlBvaKHr https://t.co/oA1b…

Mar 5, 2023 · 13 shares · 29 followers View post →
Dr Ramdas Pananthattil
@PananthattilR · X

RT @NEJM: Research Summary: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/JjLlBvaKHr https://t.co/oA1b…

Mar 5, 2023 · 13 shares · 794 followers View post →
INTERNAL MEDICINE
@medicinterna · X

RT @NEJM: Research Summary: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/JjLlBvaKHr https://t.co/oA1b…

Mar 5, 2023 · 13 shares · 2,462 followers View post →
PharmaDecisions LLC
@PharmaDecisions · X

RT @NEJM: Research Summary: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/JjLlBvaKHr https://t.co/oA1b…

Mar 5, 2023 · 13 shares · 452 followers View post →
Sweet Nurse
@SweetNurseOnco · X

RT @NEJM: Research Summary: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/JjLlBvaKHr https://t.co/oA1b…

Mar 5, 2023 · 13 shares · 8,282 followers View post →
Jihad M. Chow
@Jihad_7 · X

RT @NEJM: Research Summary: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/JjLlBvaKHr https://t.co/oA1b…

Mar 5, 2023 · 13 shares · 72 followers View post →
Charles Dariane
@CharlesDariane · X

RT @NEJM: Research Summary: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/JjLlBvaKHr https://t.co/oA1b…

Mar 5, 2023 · 13 shares · 1,078 followers View post →
Johannes Krieg
@johannes_krieg · X

RT @NEJM: Research Summary: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/JjLlBvaKHr https://t.co/oA1b…

Mar 5, 2023 · 13 shares · 68 followers View post →
Pub Health Monitor
@monitor_PH · X

RT @NEJM: Research Summary: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/JjLlBvaKHr https://t.co/oA1b…

Mar 5, 2023 · 13 shares · 1,824 followers View post →
NEJM
@NEJM · X

Research Summary: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/JjLlBvaKHr https://t.co/oA1bMgpegj

Mar 5, 2023 · 57 likes · 13 shares · 936,136 followers View post →
Sam Polesie
@SPolesie · X

RT @NEJM: In a placebo-controlled trial involving immunosuppressed organ-transplant recipients, oral nicotinamide (500 mg twice daily) for…

Mar 5, 2023 · 8 shares · 515 followers View post →
Cristian Navarrete-Dechent, MD
@DrCristianMD · X

RT @NEJM: In a placebo-controlled trial involving immunosuppressed organ-transplant recipients, oral nicotinamide (500 mg twice daily) for…

Mar 5, 2023 · 8 shares · 322 followers View post →
Carlos De la Torre, MD. PhD.
@ctorrefraga · X

“oral nicotinamide therapy did not lead to lower numbers of keratinocyte cancers or actinic keratoses in immunosuppressed solid-organ transplant recipients” Nicotina mide for Skin-Cancer Chemoprevention in Transplant Recipients | NEJM https://t.co/ZxX3hWhobY

Mar 5, 2023 · 1 like · 573 followers View post →
Adela
@adelapoite · X

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients | NEJM https://t.co/oSJRpMmENN

Mar 4, 2023 · 1,247 followers View post →
Ayman Grada, MD, MHA
@AymanGradaMD · X

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients | NEJM https://t.co/5NijUQI7Gv

Mar 3, 2023 · 822 followers View post →
Dr Ramdas Pananthattil
@PananthattilR · X

RT @NEJM: In a placebo-controlled trial involving immunosuppressed organ-transplant recipients, oral nicotinamide (500 mg twice daily) for…

Mar 3, 2023 · 8 shares · 794 followers View post →
Nikhil Joshi
@DrNikhilJoshiMD · X

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients | NEJM https://t.co/uyHCYE140T @AADskin @AST_info

Mar 3, 2023 · 1 like · 1,258 followers View post →
mas242728
@mas242728 · X

RT @NEJM: In a placebo-controlled trial involving immunosuppressed organ-transplant recipients, oral nicotinamide (500 mg twice daily) for…

Mar 3, 2023 · 8 shares · 126 followers View post →
Medical Research Library of Brooklyn
@DMCLibraryBKLYN · X

RT @NEJM: In a placebo-controlled trial involving immunosuppressed organ-transplant recipients, oral nicotinamide (500 mg twice daily) for…

Mar 3, 2023 · 8 shares · 330 followers View post →
Rahul Anand
@Justrahulanand · X

RT @NEJM: In a placebo-controlled trial involving immunosuppressed organ-transplant recipients, oral nicotinamide (500 mg twice daily) for…

Mar 3, 2023 · 8 shares · 2,464 followers View post →
Pub Health Monitor
@monitor_PH · X

RT @NEJM: In a placebo-controlled trial involving immunosuppressed organ-transplant recipients, oral nicotinamide (500 mg twice daily) for…

Mar 3, 2023 · 8 shares · 1,824 followers View post →
NEJM
@NEJM · X

In a placebo-controlled trial involving immunosuppressed organ-transplant recipients, oral nicotinamide (500 mg twice daily) for 12 months did not lead to lower numbers of keratinocyte cancers or actinic keratoses. https://t.co/JjLlBvaKHr https://t.co/v7E9yGOi49

Mar 3, 2023 · 23 likes · 8 shares · 936,136 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/AN1fTTKN12

Mar 3, 2023 · 18,507 followers View post →
DNA Repair Articles
@DNA_Repair_JC · X

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients. https://t.co/m7vS6xHPp4

Mar 2, 2023 · 1,148 followers View post →
Stephene Blair
@skincar57468141 · X

#Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients. #dermaworld #skincare #research #vitaminB12 Submissions for the upcoming issue are opened. For any queries, please contact- skincare@escientificjournals.com For more details visit: https://t.co/3MUAZO0hoA

Mar 2, 2023 · 2 likes · 50 followers View post →
Louise Sharpe
@LSharpeUSYD · X

RT @hagsie: In this #RCT we found #nicotinamide did not reduce #SkinCancers in #TransplantRecipients @NEJM - have listen to the short-ta…

Mar 2, 2023 · 1 share · 3,583 followers View post →
Theriaque_officiel
@Theriaque_CNHIM · X

Echec de la vitamine B3 en prévention des cancers de la peau chez les personnes greffées avec antécédents https://t.co/jGrdjfcnQn https://t.co/p7ZLECp8KE

Mar 2, 2023 · 1,790 followers View post →
manuel macia heras
@mmacia25 · X

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients | NEJM https://t.co/6GEVwseces

Mar 2, 2023 · 1 like · 817 followers View post →
Camilo J. Llamoza-Torres
@CamiloJT · X

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients | NEJM https://t.co/VibkFMoUkb

Mar 1, 2023 · 1,287 followers View post →
DrRPalmquist
@DrPalmquist · X

RT @agingdoc1: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/6WIbTocKXR https://t.co/OMOIpG08pB

Mar 1, 2023 · 4 shares · 3,166 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @agingdoc1: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/6WIbTocKXR https://t.co/OMOIpG08pB

Mar 1, 2023 · 4 shares · 32,517 followers View post →
Agingdoc
@agingdoc1 · X

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/6WIbTocKXR https://t.co/OMOIpG08pB

Mar 1, 2023 · 25 likes · 4 shares · 41,779 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/kA2zicPwMo

Mar 1, 2023 · 2,239 followers View post →
Prof. Haryana Dhillon
@hagsie · X

In this #RCT we found #nicotinamide did not reduce #SkinCancers in #TransplantRecipients @NEJM - have listen to the short-take recording https://t.co/HGn9GP14Ve @janette_vardy

Mar 1, 2023 · 1 like · 1 share · 4,525 followers View post →
renalRCTs
@renalRCTs · X

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients https://t.co/0EnfjcXmiI https://t.co/SICF3fg00t

Mar 1, 2023 · 39 followers View post →