Development, initial validation, and application of a visual read method for [F]MK-6240 tau PET.

Joanna L Shuping, Dawn C Matthews, Katarzyna Adamczuk, David Scott, Christopher C Rowe, William C Kreisl, Sterling C Johnson, Ana S Lukic, Keith A Johnson, Pedro Rosa-Neto, Randolph D Andrews, Koen Van Laere, Lindsay Cordes, Larry Ward, Claire L Wilde

February 2023 Alzheimers Dement (N Y)

Synopsis of Social media discussions

Several social discussions praise the study for its robust validation and potential to enhance early AD diagnosis, with phrases like 'excellent trainability' and 'supporting clinical use.' The tone conveys excitement about the method's reproducibility and relevance, reflecting a strong consensus on its importance.

A
Agreement
 Strong agreement

Most discussions agree that the visual read method is a reliable and valuable advancement for diagnosing AD, emphasizing its validation and clinical relevance.

I
Interest
 High level of interest

Participants show high interest by discussing the method's trainability, reproducibility, and potential to improve clinical diagnostics.

E
Engagement
 High engagement

The comments reflect deep engagement through detailed analysis of the method's application, reproducibility, and implications for practice.

I
Impact
 High level of impact

The discussions highlight the significant potential impact of this method in clinical settings, improving diagnostic accuracy and staging of Alzheimer's disease.

Social Mentions

YouTube

1 Videos

Twitter

1 Posts

News

2 Articles

Metrics

Video Views

17

Total Likes

2

Extended Reach

6,176

Social Features

4

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Development and Validation of a Visual Tau PET Reading Method for Alzheimer's Diagnosis

Development and Validation of a Visual Tau PET Reading Method for Alzheimer's Diagnosis

This study developed and validated a visual read method for FMK6240 tau PET scans to distinguish Alzheimer's disease from non-AD cases, focusing on regional brain uptake patterns. High inter-reader agreement supports its clinical use.

Social RTCL TV

June 23, 2023

17 views

  • UCSF MAC
    @UCSFmac (Twitter)

    Development, initial validation, and application of a visual read method for [18F]MK‐6240 tau PET. The method demonstrates excellent trainability, reproducibility, and clinical relevance supporting clinical use. https://t.co/tlzsuzAqQN https://t.co/7sYikjSGfY
    view full post

    April 7, 2023

    2

Abstract Synopsis

  • The study developed and validated a visual read method for FMK6240 tau PET scans to effectively distinguish and stage Alzheimer's disease (AD) from non-AD cases, focusing on regional brain uptake patterns.
  • Multiple expert readers assessed a set of 30 scans using different methods, and their agreement confirmed that the regions could be reliably read; a majority rule established a gold standard classification.
  • The final classification system identified four categories based on tau uptake, achieved high inter-reader agreement, and showed consistency with known pathology, supporting its clinical applicability for diagnosing and staging AD.]