March 2023 PMID 36899164

Sampling the proteome by emerging single-molecule and mass spectrometry methods.

Michael J MacCoss, Javier Antonio Alfaro, Danielle A Faivre, Christine C Wu, Meni Wanunu, Nikolai Slavov

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Peak: 12 in Dec 2024

across 5 sources since Jul 2022

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Jul 2022 – Nov 2025

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What people are saying

The group expresses high interest and perceived impact through comments about innovative methods and future potential, such as mentions of nanopore techniques and proteomics advances, with tone emphasizing the importance of this research for biological discovery and technological progress.

AgreementModerate agreement

Most discussions recognize the significance of the article and its methods, highlighting the promising advances in proteomics technology.

InterestHigh interest

The majority of posts are highly engaged, referencing specific techniques like single-molecule methods and mass spectrometry, indicating strong interest.

EngagementModerate engagement

Posts include mentions of webinars, figures, and insights from experts, showing moderate to deep engagement with the research.

ImpactHigh impact

Shared resources, figure references, and plans to discuss technological implications demonstrate that users see high potential impact in this work.

Abstract in brief

Mammalian cells contain around 30,000 times more protein molecules than mRNA, highlighting a key challenge in proteomics technology development.
Strategies for counting billions of protein molecules using liquid chromatography-tandem mass spectrometry (LC-MS/MS) are discussed.
These strategies may improve single-molecule methods by addressing the difficulties posed by the extensive dynamic range of the proteome.

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All mentions

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Advances in Single-Cell Mass Spectrometry Proteomics

Prof Nikolai Slavov discusses trends and challenges in single-cell mass spectrometry proteomics, focusing on massively parallel sample preparation and strategies to improve sensitivity and data depth for proteome…

Nikolai Slavov · Jul 14, 2024 1,173 views

Advances in Single-Molecule Proteomics for Detailed Cell Analysis

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Nikolai Slavov · Jul 14, 2022 1,074 views

Proteomics Insights: Single-Cell Variation and Molecular Mechanisms

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Nikolai Slavov · Jul 17, 2023 609 views

Single-Molecule Proteomics: Trends and Technologies in Protein Sequencing

Prof Jeff Nivala's presentation at SCP2024 covers the latest trends in single-molecule proteomics, including strategies to quantify billions of protein molecules using advanced mass spectrometry methods to overcome…

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Exploring Trends in Single-Cell Proteomics at SCP2024

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Advancements in Single-Cell Proteomics with plexDIA Methodology

The video discusses advancements in single-cell proteomics using mass spectrometry focusing on overcoming current limitations. plexDIA is highlighted as a framework for increasing throughput and sensitivity…

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Advances in Single-Cell Proteomics Techniques and Challenges

Panel discussion at SCP2025 on major trends and opportunities in single-cell proteomics, focusing on emerging single-molecule and mass spectrometry methods to analyze the proteome's complexity.

Nikolai Slavov · Jun 26, 2025 54 views

Prof. Nikolai Slavov

@slavov_n · X

RT @SCP_meeting: Introductory remarks at #SCP2025 Building a diverse and collaborative community Making proteomics more accessible, scal…

Jun 14, 2025 · 1 share · 19,819 followers View post →

Single-Cell Proteomics Conference

@SCP_meeting · X

Introductory remarks at #SCP2025 Building a diverse and collaborative community Making proteomics more accessible, scalable and powerful https://t.co/CclU8zaCbS

Jun 14, 2025 · 2 likes · 1 share · 2,196 followers View post →

Lil Caesar

@_LittleFire1 · X

Unveiling Proteins: The Future Of Single-Cell Proteomics With Professor ... https://t.co/wuUtJm01Eo via @YouTube $QSI if you wanna know why its gonna be a banger watch!

Jun 11, 2025 · 2,226 followers View post →

Ljubomir Josifovski

@ljupc0 · X

RT @slavov_n: I keep hearing from people who have either listen to or watched this podcast. They often tell that my perspective was new to…

Mar 4, 2025 · 2 shares · 5,570 followers View post →

CopperKettle

@Artyom_Yekat · X

RT @slavov_n: I keep hearing from people who have either listen to or watched this podcast. They often tell that my perspective was new to…

Mar 2, 2025 · 2 shares · 377 followers View post →

Prof. Nikolai Slavov

@slavov_n · X

Mar 1, 2025 · 20 likes · 2 shares · 19,819 followers View post →

ddhb

@ddhb80180543 · X

RT @slavov_n: I keep getting questions that are answered in this @naturemethods article. So, I will re-share it. https://t.co/DVUfMIX4Pk

Dec 14, 2024 · 13 shares · 14 followers View post →

Xavier F.

@xf_grely · X

RT @slavov_n: I keep getting questions that are answered in this @naturemethods article. So, I will re-share it. https://t.co/DVUfMIX4Pk

Dec 14, 2024 · 13 shares · 168 followers View post →

AngryPhDstudent❗️❗️❗️

@ONNESHA092 · X

RT @slavov_n: I keep getting questions that are answered in this @naturemethods article. So, I will re-share it. https://t.co/DVUfMIX4Pk

Dec 14, 2024 · 13 shares · 187 followers View post →

Jalees Rehman

@jalees.bsky.social · Bluesky

Sampling the proteome by emerging single-molecule and mass spectrometry methods www.nature.com/articles/s41... in @naturemethods.bsky.social by @slavov-n.bsky.social

Dec 14, 2024 · 2 likes View post →

Haruka Ozaki (尾崎遼)

@yuifu · X

RT @slavov_n: I keep getting questions that are answered in this @naturemethods article. So, I will re-share it. https://t.co/DVUfMIX4Pk

Dec 14, 2024 · 13 shares · 4,206 followers View post →

Paul Lourdu Xavier

@PaulLXavier · X

RT @slavov_n: I keep getting questions that are answered in this @naturemethods article. So, I will re-share it. https://t.co/DVUfMIX4Pk

Dec 13, 2024 · 13 shares · 1,182 followers View post →

Ahmed Ezat

@AhmedAdelEzat · X

RT @slavov_n: I keep getting questions that are answered in this @naturemethods article. So, I will re-share it. https://t.co/DVUfMIX4Pk

Dec 13, 2024 · 13 shares · 88 followers View post →

Carlos E Alvarez

@CarlosEAlvare17 · X

RT @slavov_n: I keep getting questions that are answered in this @naturemethods article. So, I will re-share it. https://t.co/DVUfMIX4Pk

Dec 13, 2024 · 13 shares · 1,069 followers View post →

Jean-Francois Trempe

@jftrempe · X

RT @slavov_n: I keep getting questions that are answered in this @naturemethods article. So, I will re-share it. https://t.co/DVUfMIX4Pk

Dec 13, 2024 · 13 shares · 453 followers View post →

Prof(ret.) Dr Rune Linding 

@RuneLinding · X

RT @slavov_n: I keep getting questions that are answered in this @naturemethods article. So, I will re-share it. https://t.co/DVUfMIX4Pk

Dec 13, 2024 · 13 shares · 3,059 followers View post →

Prof. Nikolai Slavov

@slavov_n · X

I keep getting questions that are answered in this @naturemethods article. So, I will re-share it. https://t.co/DVUfMIX4Pk

Dec 13, 2024 · 48 likes · 13 shares · 19,977 followers View post →

Michael MacCoss

@maccoss.bsky.social · Bluesky

Figure 2 has an example figure of this. pubmed.ncbi.nlm.nih.gov/36899164/ We also have this implemented as part of Limelight limelight-ms.readthedocs.io/en/latest/#c... @mriffle.bsky.social

Dec 6, 2024 · 4 likes · 1 share View post →

Supurmario basler

@SupurmarioH · X

RT @slavov_n: Enjoy the weekend with a discussion about proteomic technologies & the biology progress that they can enable. They may unblo…

Oct 12, 2024 · 3 shares · 34 followers View post →

whadjuk noongar

@Vickstar2618 · X

RT @slavov_n: Enjoy the weekend with a discussion about proteomic technologies & the biology progress that they can enable. They may unblo…

Oct 12, 2024 · 3 shares · 1,305 followers View post →

Slavov Laboratory

@slavovLab · X

RT @slavov_n: Enjoy the weekend with a discussion about proteomic technologies & the biology progress that they can enable. They may unblo…

Oct 12, 2024 · 3 shares · 2,799 followers View post →

Prof. Nikolai Slavov

@slavov_n · X

Enjoy the weekend with a discussion about proteomic technologies & the biology progress that they can enable. They may unblock biology research. https://t.co/Ts6lZsTdnE

Oct 12, 2024 · 15 likes · 3 shares · 19,819 followers View post →

Prof. Nikolai Slavov

@slavov_n · X

@ProteomicsNews The service fees / hour charged by mass spec facilities should provide a good rough estimate. We have used such estimates in our articles: https://t.co/DVUfMIX4Pk

Apr 16, 2024 · 1 like · 19,977 followers View post →

Sehbanul Islam

@sehbanamu · X

RT @SCP_meeting: The talk by Prof. Meni Wanunu (@WanunuLab) at #SCP2023 is on YouTube: Single-molecule proteomics using nanopores https:/…

Jul 18, 2023 · 6 shares · 641 followers View post →

david

@Minde_DavidPaul · X

RT @SCP_meeting: The talk by Prof. Meni Wanunu (@WanunuLab) at #SCP2023 is on YouTube: Single-molecule proteomics using nanopores https:/…

Jul 18, 2023 · 6 shares · 66 followers View post →

Carnesecchi Julie

@CarnesecchiJ · X

RT @SCP_meeting: The talk by Prof. Meni Wanunu (@WanunuLab) at #SCP2023 is on YouTube: Single-molecule proteomics using nanopores https:/…

Jul 18, 2023 · 6 shares · 567 followers View post →

Hirohito Yamazaki

@hiroyama1988 · X

RT @SCP_meeting: The talk by Prof. Meni Wanunu (@WanunuLab) at #SCP2023 is on YouTube: Single-molecule proteomics using nanopores https:/…

Jul 18, 2023 · 6 shares · 247 followers View post →

Kawano Lab. (東京農工大学川野研究室)

@KawanoLab__tuat · X

RT @SCP_meeting: The talk by Prof. Meni Wanunu (@WanunuLab) at #SCP2023 is on YouTube: Single-molecule proteomics using nanopores https:/…

Jul 18, 2023 · 6 shares · 1,170 followers View post →

Keisuke Motone / 元根啓佑

@KeisukeMotone · X

RT @SCP_meeting: The talk by Prof. Meni Wanunu (@WanunuLab) at #SCP2023 is on YouTube: Single-molecule proteomics using nanopores https:/…

Jul 18, 2023 · 6 shares · 639 followers View post →

Single-Cell Proteomics Conference

@SCP_meeting · X

The talk by Prof. Meni Wanunu (@WanunuLab) at #SCP2023 is on YouTube: Single-molecule proteomics using nanopores https://t.co/PL3rQWarOd

Jul 18, 2023 · 22 likes · 6 shares · 2,196 followers View post →

Single-Cell Proteomics Conference

@SCP_meeting · X

The talk by Dr. Brian Reed at #SCP2023 is on YouTube: Advances in single-molecule protein sequencing on the Quantum-Si platform https://t.co/kjlTUqyMCo

Jul 14, 2023 · 2,196 followers View post →

CancerVaccines

@ic2_vs · X

Mar 23, 2023 · 3 likes · 138 followers View post →

Gemma

@gbarroso36 · X

RT @PastelBio: Sampling the proteome by emerging single-molecule and mass spectrometry methods | https://t.co/PxaVrCuFlt #proteomics https…

Mar 15, 2023 · 1 share · 119 followers View post →

BioMassSpec

@realBioMassSpec · X

Sampling the proteome by emerging single-molecule and mass spectrometry methods #NatMethods https://t.co/LyicvsjCcI

Mar 11, 2023 · 5,993 followers View post →

Pastel BioScience

@PastelBio · X

Sampling the proteome by emerging single-molecule and mass spectrometry methods | https://t.co/PxaVrCuFlt #proteomics https://t.co/n9jVIwordH

Mar 11, 2023 · 2 likes · 1 share · 5,375 followers View post →

Kermit Murray

@kermitmurray · X

(Nature MS) Sampling the proteome by emerging single-molecule and mass spectrometry methods https://t.co/4D8igHE7fe (RSS) #nature #MassSpec https://t.co/nfULzZzejV

Mar 10, 2023 · 2 likes · 1,968 followers View post →

UW Genome Sciences

@uwgenome · X

Sampling the proteome by emerging single-molecule and mass spectrometry methods https://t.co/s100kz9VuK

Mar 10, 2023 · 4 likes · 2,952 followers View post →

Seiichi Mori

@seiichi_mori · X

Sampling the proteome by emerging single-molecule and mass-spectrometry methods https://t.co/P9TNtCGWqN https://t.co/SwOFoIhXkY

Sep 21, 2022 · 314 followers View post →

Andrea Petretto

@Angrist_Fusion · X

RT @PastelBio: Sampling the proteome by emerging single-molecule and mass-spectrometry methods | https://t.co/U0cTl9nXXT #proteomics https:…

Aug 2, 2022 · 1 share · 581 followers View post →

Pastel BioScience

@PastelBio · X

Sampling the proteome by emerging single-molecule and mass-spectrometry methods | https://t.co/U0cTl9nXXT #proteomics https://t.co/W4NaU7D4wy

Aug 2, 2022 · 4 likes · 1 share · 5,375 followers View post →

Sampling the proteome by emerging single-molecule and mass spectrometry methods.

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