March 2023 PMID 36915214

Roles of neuropathology-associated reactive astrocytes: a systematic review.

Jill M Lawrence, Kayla Schardien, Brian Wigdahl, Michael R Nonnemacher

Mentions

16
Peak: 5 in Mar 2023
across 4 sources since Mar 2023

Extended reach

8,268
potential audience

Total likes

9

Video views

53

Mentions per month

Mar 2023 – Jun 2023

Where it's discussed

  • X / Twitter9 posts
  • News4 articles
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The overall tone reflects a positive attitude, with posts celebrating the publication and noting its role in expanding molecular insights into astrocyte functions in neurodegenerative diseases. The use of phrases like 'nice review paper' and emphasis on 'growing array of neuropathologies' shows enthusiasm for scientific progress, correlating with interest and engagement scores. However, direct claims of immediate impact or controversy are minimal, resulting in moderate impact and engagement scores.

AgreementModerate agreement

Most posts express positive acknowledgment of the publication, supporting its relevance and importance, as seen in praise for the authors' work which indicates general approval.

InterestHigh interest

Posts show high interest, with mentions of the systematic review's contributions to understanding astrocyte roles in neural pathologies and noting the ongoing molecular characterizations.

EngagementModerate engagement

Discussions include specific references to the research's findings and significance, such as the evolving understanding of astrocyte phenotypes in neurodegeneration, suggesting active engagement.

ImpactModerate impact

The posts imply the review could influence future research directions and deepen understanding in the field, indicating moderate impact for advancing neuropathology research.

Abstract in brief

  • Reactive astrocytes, labeled as A1-like or neuroinflammatory, are activated by signals from microglia during aging, injury, or neuroinflammation, and they shift from supportive roles to secreting neurotoxic factors.
  • These reactive astrocytes reduce their normal functions such as supporting neurons and maintaining the blood-brain barrier, and instead release harmful substances like complement component C3 and chemokines like CXCL10, which attract immune cells into the brain.
  • The presence of proinflammatory reactive astrocytes increases with age and is especially prominent in neurodegenerative diseases, with ongoing research to better understand their specific roles in various neuropathologies.

Top posts

Most liked on X and Bluesky
DrexelMCBG
@DrexelMcbg · X

Jill Lawrence @JMLOddity @DrexelMcbg PhD student in the lab of Dr. Micheal Nonnemacher @DrexelMedicine just published a nice review paper together Kayla Schardien @KaySchardien also an MCBG student!!! Well done Jill and Kayla

Apr 26, 2023 · 4 likes · 3 shares · 546 followers View post →
My Neuropath News
@NeuropathClinic · X

Roles of neuropathology-associated reactive astrocytes: a systematic review #neuropath https://t.co/MNBiyZqatV

Mar 23, 2023 · 2 likes · 2 shares · 1,580 followers View post →
Office of Graduate Studies of Drexel University
@DrexelGradStudy · X

RT @DrexelMcbg: Jill Lawrence @JMLOddity @DrexelMcbg PhD student in the lab of Dr. Micheal Nonnemacher @DrexelMedicine just published a ni…

Apr 27, 2023 · 3 shares · 1,462 followers View post →
LIU Dawei, M.D., Ph.D.
@liudawei05329 · X

RT @NeuropathClinic: Roles of neuropathology-associated reactive astrocytes: a systematic review #neuropath https://t.co/MNBiyZqatV

Mar 23, 2023 · 2 shares · 1,175 followers View post →
Noguchi Laboratory
@NoguchiLab2004 · X

RT @DrexelMcbg: Jill Lawrence @JMLOddity @DrexelMcbg PhD student in the lab of Dr. Micheal Nonnemacher @DrexelMedicine just published a ni…

Apr 26, 2023 · 3 shares · 1,088 followers View post →
WANG Xingfu
@wangxfu · X

RT @NeuropathClinic: Roles of neuropathology-associated reactive astrocytes: a systematic review #neuropath https://t.co/MNBiyZqatV

Mar 23, 2023 · 2 shares · 998 followers View post →

All mentions

Office of Graduate Studies of Drexel University
@DrexelGradStudy · X

RT @DrexelMcbg: Jill Lawrence @JMLOddity @DrexelMcbg PhD student in the lab of Dr. Micheal Nonnemacher @DrexelMedicine just published a ni…

Apr 27, 2023 · 3 shares · 1,462 followers View post →
Kayla Schardien, PhD
@KaySchardien · X

RT @DrexelMcbg: Jill Lawrence @JMLOddity @DrexelMcbg PhD student in the lab of Dr. Micheal Nonnemacher @DrexelMedicine just published a ni…

Apr 26, 2023 · 3 shares · 326 followers View post →
Noguchi Laboratory
@NoguchiLab2004 · X

RT @DrexelMcbg: Jill Lawrence @JMLOddity @DrexelMcbg PhD student in the lab of Dr. Micheal Nonnemacher @DrexelMedicine just published a ni…

Apr 26, 2023 · 3 shares · 1,088 followers View post →
DrexelMCBG
@DrexelMcbg · X

Jill Lawrence @JMLOddity @DrexelMcbg PhD student in the lab of Dr. Micheal Nonnemacher @DrexelMedicine just published a nice review paper together Kayla Schardien @KaySchardien also an MCBG student!!! Well done Jill and Kayla

Apr 26, 2023 · 4 likes · 3 shares · 546 followers View post →
Orlando_uy
@Orlando_uy · X

Roles of neuropathology-associated reactive astrocytes: a systematic review. "As the identification of astrocyte phenotypes progress, their molecular and cellular effects are characterized in a growing array of neuropathologies." https://t.co/iRxKmmM8KM

Mar 27, 2023 · 694 followers View post →
LIU Dawei, M.D., Ph.D.
@liudawei05329 · X

RT @NeuropathClinic: Roles of neuropathology-associated reactive astrocytes: a systematic review #neuropath https://t.co/MNBiyZqatV

Mar 23, 2023 · 2 shares · 1,175 followers View post →
WANG Xingfu
@wangxfu · X

RT @NeuropathClinic: Roles of neuropathology-associated reactive astrocytes: a systematic review #neuropath https://t.co/MNBiyZqatV

Mar 23, 2023 · 2 shares · 998 followers View post →
My Neuropath News
@NeuropathClinic · X

Roles of neuropathology-associated reactive astrocytes: a systematic review #neuropath https://t.co/MNBiyZqatV

Mar 23, 2023 · 2 likes · 2 shares · 1,580 followers View post →
MS Papers
@MltplSclppr · X

Roles of neuropathology-associated reactive astrocytes: a systematic review https://t.co/mpsarNIGE2

Mar 16, 2023 · 311 followers View post →