Adv Sci (Weinh) May 2023 PMID 36961096

A Sleep-Specific Midbrain Target for Sevoflurane Anesthesia.

Tingting Yi, Na Wang, Jing Huang, Yaling Wang, Shuancheng Ren, Yiwen Hu, Jianxia Xia, Yixiang Liao, Xin Li, Fenlan Luo, Qin Ouyang, Yu Li, Ziyi Zheng, Qin Xiao, Rong Ren

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Peak: 1 in Mar 2023

across 2 sources since Mar 2023

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261

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Mar 2023 – Aug 2023

Where it's discussed

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AI synopsis

What people are saying

The discussions reflect a general agreement on the importance of identifying midbrain targets for anesthesia, with posts mentioning specific neurons and receptors like GHSR, UCN1, and CART, demonstrating both interest and engagement. Words like 'promising' and 'potential' highlight optimism about the study's impact, while references to mechanisms and future applications show active participation and curiosity about the findings.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, with some expressing enthusiasm about its potential implications.

InterestModerate interest

Participants show moderate interest, discussing the neural mechanisms and possible applications in anesthesia.

EngagementModerate engagement

Posts reference specific mechanisms like GHSR, UCN1, and CART, indicating a reasonably deep engagement with the scientific details.

ImpactModerate impact

The collective tone suggests an optimistic view that this research could influence future anesthetic development and sleep studies.

Abstract in brief

Sevoflurane, a common inhaled anesthetic, works by activating specific neurons in the midbrain, particularly those involving urocortin 1 (UCN1) and CART, which are important for inducing anesthesia and sleep.
The growth hormone secretagogue receptor (GHSR) is found in these neurons and is essential for sevoflurane's sleep-inducing effects; blocking GHSR prevents the anesthetic from exciting these neurons.
Overall, the study suggests that targeting GHSR in the midbrain UCN1 and CART neurons could provide new ways to understand and develop anesthetic drugs.

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All mentions

Midbrain Neurons as Targets for Sevoflurane-Induced Sleep and Anesthesia

Sevoflurane activates specific midbrain neurons involving UCN1 and CART, critical for inducing sleep and anesthesia. Blocking growth hormone secretagogue receptors (GHSR) in these neurons prevents anesthetic excitation…

STEM RTCL TV · Aug 25, 2023 162 views

SleepPapers

@PapersSleep · X

A Sleep-Specific Midbrain Target for Sevoflurane Anesthesia https://t.co/PdjLAE8Zzo https://t.co/KDi8HHCt62

Mar 24, 2023 · 99 followers View post →