PubHawk
Genome Med March 2023 PMID 36978128

X chromosome dosage and the genetic impact across human tissues.

Mette Viuff, Anne Skakkebæk, Emma B Johannsen, Simon Chang, Steen Bønlykke Pedersen, Katrine Meyer Lauritsen, Mette Glavind Bülow Pedersen, Christian Trolle, Jesper Just, Claus H Gravholt

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Mentions

10
Peak: 7 in Mar 2023
across 3 sources since Mar 2023

Extended reach

9,609
potential audience

Total likes

24

Video views

44

Mentions per month

Mar 2023 – Jul 2023

Where it's discussed

  • X / Twitter7 posts
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions collectively praise the study’s exploration of how variations in X chromosome number influence gene expression across tissues, with phrases like 'complex tissue-specific effects' and 'genome-wide impacts' showing engagement with the detailed biological findings, while references to conditions like Turner syndrome and Klinefelter syndrome signify the perceived importance of the research for understanding human genetics.

AgreementModerate agreement

Most discussions acknowledge the significance of the study, emphasizing its findings on the complexity of biological sex and gene regulation related to X chromosome variations.

InterestHigh interest

Posts express high curiosity, highlighting aspects like tissue-specific effects and the broader implications of the research.

EngagementHigh engagement

Many comments delve into detailed interpretations, referencing specific chromosome conditions (e.g., 45X, 47XXY) and engaging with concepts about gene and epigenetic impacts.

ImpactHigh impact

The discussions reflect a recognition that the study's insights could influence understanding of sex chromosome aneuploidies and related phenotypes, showing the research's substantial relevance.

Abstract in brief

  • The study examines how variations in X chromosome number (such as in Turner syndrome 45X, typical females 46XX, males 46XY, and Klinefelter syndrome 47XXY) impact gene expression and DNA methylation across different tissues like blood, fat, and muscle.
  • Results show that differences in X chromosome count lead to specific, tissue-dependent changes in gene activity and epigenetic modifications, with 45X generally showing gene downregulation and 47XXY showing gene upregulation, along with distinct methylation patterns.
  • The research identified certain X-linked genes that behave differently than expected based on chromosome number, suggesting these genes, along with Y-chromosomal genes, play key roles in regulating sex chromosome aneuploidies and their associated phenotypes.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Jesper Just
@Jesper__Just · X

Our new study shows that biological sex isn’t just binary – it’s a complex and tissue-specific orchestra! We dive into the fascinating effects of X chromosome number on gene regulation in individuals with sex chromosome aneuploidies #45X #47XXY. @moma_dk https://t.co/48EBU5Tver

Mar 29, 2023 · 14 likes · 1 share · 94 followers View post →
Mette H. viuff
@ViuffH · X

In this study, we explore the wonders of the X chromosome and dissect how a missing X or a supernumerary X chromosome affect the entire genome across several human tissues. @chgravholt Anne Skakkebæk @Jesper__Just @EBJohannsen https://t.co/JvGizX6eBX

Mar 29, 2023 · 8 likes · 43 followers View post →
epigenetics_papers
@epigen_papers · X

Pubmed: X chromosome dosage and the genetic impact across human tissues https://t.co/AeIGE3jySu

Mar 29, 2023 · 1 like · 6,726 followers View post →
Transcriptomes
@transcriptomes · X

X chromosome dosage and the genetic impact across human tissues. https://t.co/TlrMdag2Ep

Mar 29, 2023 · 1,809 followers View post →
SexGenomics
@sexgenomics · X

X chromosome dosage and the genetic impact across human tissues https://t.co/Fya8zl9zm5

Mar 29, 2023 · 815 followers View post →
Mette H. viuff
@ViuffH · X

RT @Jesper__Just: Our new study shows that biological sex isn’t just binary – it’s a complex and tissue-specific orchestra! We dive into th…

Mar 29, 2023 · 1 share · 43 followers View post →

All mentions

ychrompapers
@ychrom_papers · X

X chromosome dosage and the genetic impact across human tissues https://t.co/MfO1CkJXcS https://t.co/kuiF9ckC8k

Mar 30, 2023 · 32 followers View post →
Transcriptomes
@transcriptomes · X

X chromosome dosage and the genetic impact across human tissues. https://t.co/TlrMdag2Ep

Mar 29, 2023 · 1,809 followers View post →
Mette H. viuff
@ViuffH · X

In this study, we explore the wonders of the X chromosome and dissect how a missing X or a supernumerary X chromosome affect the entire genome across several human tissues. @chgravholt Anne Skakkebæk @Jesper__Just @EBJohannsen https://t.co/JvGizX6eBX

Mar 29, 2023 · 8 likes · 43 followers View post →
Mette H. viuff
@ViuffH · X

RT @Jesper__Just: Our new study shows that biological sex isn’t just binary – it’s a complex and tissue-specific orchestra! We dive into th…

Mar 29, 2023 · 1 share · 43 followers View post →
Jesper Just
@Jesper__Just · X

Our new study shows that biological sex isn’t just binary – it’s a complex and tissue-specific orchestra! We dive into the fascinating effects of X chromosome number on gene regulation in individuals with sex chromosome aneuploidies #45X #47XXY. @moma_dk https://t.co/48EBU5Tver

Mar 29, 2023 · 14 likes · 1 share · 94 followers View post →
SexGenomics
@sexgenomics · X

X chromosome dosage and the genetic impact across human tissues https://t.co/Fya8zl9zm5

Mar 29, 2023 · 815 followers View post →
epigenetics_papers
@epigen_papers · X

Pubmed: X chromosome dosage and the genetic impact across human tissues https://t.co/AeIGE3jySu

Mar 29, 2023 · 1 like · 6,726 followers View post →