A-MYB and BRDT-dependent RNA Polymerase II pause release orchestrates transcriptional regulation in mammalian meiosis.

Adriana K Alexander, Edward J Rice, Jelena Lujic, Leah E Simon, Stephanie Tanis, Gilad Barshad, Lina Zhu, Jyoti Lama, Paula E Cohen, Charles G Danko

March 2023 Nat Commun

Synopsis of Social media discussions

The discussions highlight the significance of A-MYB and BRDT in controlling transcription during meiosis, using words like 'crucial' and 'key,' which convey strong support and interest. Comments like 'mediation of gene transcription' and references to the 'pause release' process show active engagement, while recognition of potential broader applications hints at their perceived impact.

A
Agreement
 Moderate agreement

Most discussions acknowledge the importance of the research in understanding transcription regulation during meiosis, reflecting general support for the findings.

I
Interest
 High level of interest

Responses demonstrate high curiosity with repeated mentions of the transcription mechanism and its relevance, showing strong interest.

E
Engagement
 Moderate level of engagement

There are posts that incorporate specific biological processes, indicating active engagement, though not deeply technical.

I
Impact
 Moderate level of impact

Participants seem to recognize the potential implications for genetics and reproductive biology, suggesting moderate perceived impact.

Social Mentions

YouTube

1 Videos

Twitter

3 Posts

Metrics

Video Views

23

Total Likes

2

Extended Reach

150,293

Social Features

4

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

RNA Polymerase II Pause Release Regulates Transcription in Mammalian Meiosis

RNA Polymerase II Pause Release Regulates Transcription in Mammalian Meiosis

This video explores how transcription is regulated during mammalian meiosis, focusing on the role of Pol II, AMYB, and BRDT in gene activation and chromatin accessibility during reproductive cell development.

STEM RTCL TV

July 24, 2023

23 views

  • meiosispapers @meiosis_papers@mstdn.science
    @meiosis_papers (Twitter)

    A-MYB and BRDT-dependent RNA Polymerase II pause release orchestrates transcriptional regulation in mammalian meiosis | Adriana K Alexander | https://t.co/qE7RCm3vV4
    view full post

    March 30, 2023

    1

    1

  • bioRxiv Genomics
    @biorxiv_genomic (Twitter)

    Meiotic gene transcription programs are mediated by A-MYB and BRDT-dependent RNA polymerase II pause release during mammalian prophase I https://t.co/zVHx7xyVr0 #biorxiv_genomic
    view full post

    August 20, 2022

    1

  • bioRxiv
    @biorxivpreprint (Twitter)

    Meiotic gene transcription programs are mediated by A-MYB and BRDT-dependent RNA polymerase II pause release during mammalian prophase I https://t.co/bYdYkVWTGr #bioRxiv
    view full post

    August 20, 2022

    1

Abstract Synopsis

  • The study investigates how transcription is regulated during mammalian meiosis, particularly focusing on the role of Pol II and factors like AMYB and BRDT in controlling gene activation.
  • Early in prophase I, Pol II is positioned on chromatin in a paused state, and later, it is released to trigger a significant increase in transcription, coordinated by specific transcription factors.
  • The research shows that chromatin accessibility related to recombination and transcription occurs at different times and places, highlighting distinct chromatin landscapes for these two processes during meiosis.]