I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exactly the readout is (e.g., it's not a uniform sampling of active genes in a cell). Good to see work on it. https://t.co/bArGPSli3p
The shaky foundations of simulating single-cell RNA sequencing data.
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Nov 2021 – Jul 2023Where it's discussed
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X / Twitter89 posts
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YouTube1 videos
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What people are saying
Many posts refer to the shaky foundation of single-cell RNA sequencing data simulation, with phrases like 'built on sand' suggesting foundational issues in the methodology. The tone is both critical and intrigued, as seen in users expressing skepticism about the efficacy of these methods and emphasizing the necessity for further research, contributing to an overall sentiment that the publication could have significant implications for the field.
Several discussions indicate a shared skepticism towards current methods of simulating single-cell RNA sequencing data, suggesting a general agreement on the issues raised in the publication.
There is a high level of curiosity shown in the posts, with users expressing a desire to understand and critique the findings.
While many posts simply reference the publication, some users engage more deeply with the implications and methodologies, suggesting a moderate level of engagement.
The discussions reflect a strong belief that the publication could significantly influence future research in bioinformatics.
Abstract in brief
- The rise of single-cell RNA-sequencing (scRNA-seq) datasets has led to many new computational tools, prompting the need for benchmark studies to evaluate the performance of these methods compared to existing ones.
- This study focuses on assessing synthetic scRNA-seq data generation methods to see how well they replicate actual experimental data, analyzing both gene and cell quality controls and their effects on clustering and batch correction comparisons.
- Findings indicate that many simulators struggle with complex designs, often giving overly positive evaluations of integration performance and leading to uncertain conclusions about the effectiveness of different clustering methods.
Top posts
Most liked on X and BlueskyBuilt on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap7J https://t.co/GQXvfEr35Q
Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/Sm6v7VxxVZ https://t.co/pqOFxYYtfh
Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/rofjNvGcQw #bioRxiv
The shaky foundations of simulating single-cell RNA sequencing data | Genome Biology https://t.co/OIuugkau3Q #Bioinformatics https://t.co/GXYICEE3Jy
CONGRATS @CrowellHL and @markrobinsonca. #singlecell simulation tools benchmarked. Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/ec1VLt1PZs
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Evaluating the Performance of Synthetic scRNA-seq Data Generation
This study assesses synthetic scRNA-seq data generation methods, focusing on their capability to accurately replicate experimental data. We analyze gene and cell quality controls, revealing that many simulators may…
RT @BioDecoded: The shaky foundations of simulating single-cell RNA sequencing data | Genome Biology https://t.co/OIuugkau3Q #Bioinformati…
RT @BioDecoded: The shaky foundations of simulating single-cell RNA sequencing data | Genome Biology https://t.co/OIuugkau3Q #Bioinformati…
RT @BioDecoded: The shaky foundations of simulating single-cell RNA sequencing data | Genome Biology https://t.co/OIuugkau3Q #Bioinformati…
The shaky foundations of simulating single-cell RNA sequencing data | Genome Biology https://t.co/OIuugkau3Q #Bioinformatics https://t.co/GXYICEE3Jy
The shaky foundations of simulating single-cell RNA sequencing data https://t.co/9JpqkHTHss
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @DrDx11696608: The shaky foundations of simulating single-cell RNA sequencing data https://t.co/OArYe8p6wW #single #cell #RNA #Bioinform…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @DrDx11696608: The shaky foundations of simulating single-cell RNA sequencing data https://t.co/OArYe8p6wW #single #cell #RNA #Bioinform…
The shaky foundations of simulating single-cell RNA sequencing data https://t.co/OArYe8p6wW #single #cell #RNA #Bioinformatics https://t.co/Bz9WeX6XAD
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
RT @jmschreiber91: I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exact…
I was always skeptical of single-cell data simulation methods because we still have lingering questions about what exactly the readout is (e.g., it's not a uniform sampling of active genes in a cell). Good to see work on it. https://t.co/bArGPSli3p
The shaky foundations of simulating single-cell RNA sequencing data https://t.co/FI1UMEQLFj https://t.co/ydiy7xXLGv
The shaky foundations of simulating single-cell RNA sequencing data https://t.co/bXI81yY1Cu
RT @jsantoyo: The shaky foundations of simulating single-cell RNA sequencing data. #SingleCell #scRNAseq #SimulatedData @GenomeBiology htt…
The shaky foundations of simulating single-cell RNA sequencing data. #SingleCell #scRNAseq #SimulatedData @GenomeBiology https://t.co/cC960SQ7kH
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/Sm6v7VxxVZ https://t.co/pqOFxYYt…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/Sm6v7VxxVZ https://t.co/pqOFxYYt…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/Sm6v7VxxVZ https://t.co/pqOFxYYt…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/Sm6v7VxxVZ https://t.co/pqOFxYYt…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/Sm6v7VxxVZ https://t.co/pqOFxYYt…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/Sm6v7VxxVZ https://t.co/pqOFxYYt…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/Sm6v7VxxVZ https://t.co/pqOFxYYt…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/Sm6v7VxxVZ https://t.co/pqOFxYYt…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/Sm6v7VxxVZ https://t.co/pqOFxYYt…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/Sm6v7VxxVZ https://t.co/pqOFxYYt…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/Sm6v7VxxVZ https://t.co/pqOFxYYt…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/Sm6v7VxxVZ https://t.co/pqOFxYYt…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/Sm6v7VxxVZ https://t.co/pqOFxYYt…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/Sm6v7VxxVZ https://t.co/pqOFxYYt…
Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/Sm6v7VxxVZ https://t.co/pqOFxYYtfh
RT @jsantoyo: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data. #scRNAseq #DataSimulation https://t.co/BJ…
RT @jsantoyo: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data. #scRNAseq #DataSimulation https://t.co/BJ…
RT @jsantoyo: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data. #scRNAseq #DataSimulation https://t.co/BJ…
Built on sand: the shaky foundations of simulating single-cell RNA sequencing data. #scRNAseq #DataSimulation https://t.co/BJbeIAtHgP @biorxivpreprint
RT @CompBiolPapers: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data [NEW RESULTS] https://t.co/ehGr2fCfF1
Built on sand: the shaky foundations of simulating single-cell RNA sequencing data [NEW RESULTS] https://t.co/ehGr2fCfF1
RT @biorxivpreprint: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/rofjNvGcQw #bioRxiv
Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/87iiUzJS5e
CONGRATS @CrowellHL and @markrobinsonca. #singlecell simulation tools benchmarked. Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/ec1VLt1PZs
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap…
RT @biorxivpreprint: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/rofjNvGcQw #bioRxiv
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap…
RT @strnr: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap…
Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/BHUF9qTR7T https://t.co/Qkn7dUap7J https://t.co/GQXvfEr35Q
Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/8tDyeT07L1 https://t.co/Pvj4UV30gf
#bioRxiv Built on sand: the shaky foundations of simulating single-cell RNA sequencing data #bioinfo https://t.co/d6rqI4v0bb
RT @biorxivpreprint: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/rofjNvGcQw #bioRxiv
RT @biorxivpreprint: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/rofjNvGcQw #bioRxiv
RT @biorxivpreprint: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/rofjNvGcQw #bioRxiv
RT @biorxiv_bioinfo: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/ndf5o77yN0 #biorxiv_b…
RT @biorxivpreprint: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/rofjNvGcQw #bioRxiv
RT @biorxiv_bioinfo: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/ndf5o77yN0 #biorxiv_b…
RT @biorxivpreprint: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/rofjNvGcQw #bioRxiv
RT @biorxiv_bioinfo: Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/ndf5o77yN0 #biorxiv_b…
Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/ndf5o77yN0 #biorxiv_bioinfo
Built on sand: the shaky foundations of simulating single-cell RNA sequencing data https://t.co/rofjNvGcQw #bioRxiv