Genome Biol March 2023 PMID 36991492

CRISPR screens identify gene targets at breast cancer risk loci.

Natasha K Tuano, Jonathan Beesley, Murray Manning, Wei Shi, Laura Perlaza-Jimenez, Luis F Malaver-Ortega, Jacob M Paynter, Debra Black, Andrew Civitarese, Karen McCue, Aaron Hatzipantelis, Kristine Hillman, Susanne Kaufmann, Haran Sivakumaran, Jose M Polo

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Mentions

Peak: 3 in Apr 2023

across 2 sources since Apr 2023

Extended reach

3,249

potential audience

Total likes

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Mentions per month

Apr 2023 – Jul 2023

Where it's discussed

X / Twitter3 posts
YouTube1 videos

AI synopsis

What people are saying

The overall discussion reflects strong support and curiosity about the article, with comments like 'Great to finally see the published version' and mentions of the researchers involved. The tone uses positive language such as 'identify gene targets' and 'opportunities,' underscoring the perceived importance and potential impact of the study on breast cancer genetics research.

AgreementModerate agreement

Most discussions express support or positive acknowledgment of the research, highlighting its significance and confirming its findings.

InterestHigh interest

Participants show a high level of interest, with mentions of specific researchers, publication details, and implications for breast cancer research.

EngagementModerate engagement

The discussions include references to the methodology, such as CRISPR screens, and enthusiasm about the study’s contributions, indicating active engagement.

ImpactHigh impact

The discussions suggest a recognition of the study’s potential to influence future research and therapeutic strategies, emphasizing its meaningful contribution.

Abstract in brief

Genome-wide association studies (GWAS) have linked over 200 genetic regions to breast cancer risk, primarily involving non-coding variants that influence gene expression.
Pooled CRISPR screens were used in this study to effectively identify target genes from GWAS and the cancer-related traits they influence, involving extensive experimentation on gene activation and the effects on cell proliferation and DNA repair.
The research confirms that CRISPR screens can accurately identify the gene targets of risk loci, creating a new method for investigating how specific genetic variants relate to breast cancer risk.

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All mentions

CRISPR Screening Reveals Genes Linked to Breast Cancer Risk

CRISPR screens identify gene targets at breast cancer risk loci. This study confirms that CRISPR can accurately determine genes associated with genetic risk variants, advancing understanding of how these impact cancer…

Social RTCL TV · Jul 20, 2023 18 views

CRISP_SCIENCE

@ScienceCrisp · X

“#CRISPR screens identify gene targets and drug repositioning opportunities at breast cancer risk loci" Tuano NK [..] Chenevix-Trench G, Rosenbluh J. Genome Biol 2023-03-29. https://t.co/3Q4KgrB7Hm

Apr 13, 2023 · 1 like · 1,917 followers View post →

Joanna Achinger-Kawecka

@aachinger · X

RT @JulietFrench01: Great to finally see the published version of this work led by @RosenbluhSefi and ⁦@GeorgiaTrench⁩. CRISPR screens iden…

Apr 5, 2023 · 1 share · 925 followers View post →

Juliet French

@JulietFrench01 · X

Great to finally see the published version of this work led by @RosenbluhSefi and ⁦@GeorgiaTrench⁩. CRISPR screens identify gene targets at breast cancer risk loci. https://t.co/MRP3t59Ao5

Apr 4, 2023 · 4 likes · 1 share · 385 followers View post →