Nat Commun March 2023 PMID 36997511

The plant unique ESCRT component FREE1 regulates autophagosome closure.

Yonglun Zeng, Baiying Li, Shuxian Huang, Hongbo Li, Wenhan Cao, Yixuan Chen, Guoyong Liu, Zhenping Li, Chao Yang, Lei Feng, Jiayang Gao, Sze Wan Lo, Jierui Zhao, Jinbo Shen, Yan Guo

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Peak: 4 in Mar 2023

across 2 sources since Mar 2023

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What people are saying

The discussions reflect a positive reception, emphasizing the significance of FREE1 in autophagosome closure using words like 'regulates' and 'crucial role,' and mentioning advanced methods and protein interactions, which demonstrate a substantial interest and engagement with the research's biological and technical components.

AgreementModerate agreement

Most discussions acknowledge the importance of FREE1 in autophagosome closure, indicating general agreement with the findings.

InterestHigh interest

The discussions reflect high interest, with mentions of advanced techniques, key proteins, and potential implications, suggesting engagement with the research topic.

EngagementModerate engagement

People reference specific aspects like the ESCRT component and phosphorylation processes, showing moderate depth in discussions.

ImpactModerate impact

The posts hint at significance within plant biology and cellular processes, but there is limited evidence of debates or calls for further application, so impact is seen as noteworthy but not revolutionary.

Abstract in brief

The study reveals that the plant-specific protein FREE1 plays a crucial role in autophagosome closure, linking the autophagy machinery with energy sensing pathways, specifically through phosphorylation by the energy sensor SnRK11.
Using advanced imaging and biochemical techniques, researchers observed that mutants lacking FREE1 accumulated unclosed autophagosomes, highlighting its importance in the process of autophagy during nutrient deprivation.
The findings demonstrate that energy sensing through SnRK11 regulates autophagosome closure by phosphorylating FREE1, providing insight into how cellular energy status influences autophagy to maintain plant cellular health.]

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Role of FREE1 in Autophagosome Closure and Energy Sensing in Plants

The study reveals that the plant-specific protein FREE1 plays a crucial role in autophagosome closure, linking the autophagy machinery with energy sensing pathways through phosphorylation by SnRK11. This highlights how…

STEM RTCL TV · Jul 18, 2023 36 views

Agrisera

@agrisera · X

Aug 22, 2023 · 1 like · 658 followers View post →

Kaushal K Bhati

@Kaushal_Bhati · X

The plant unique ESCRT component FREE1 regulates autophagosome closure https://t.co/AG7uLewBt2

Apr 2, 2023 · 5 likes · 1,782 followers View post →

BüttnerLab

@ButtnerLab · X

The plant unique ESCRT component FREE1 regulates autophagosome closure | Nature Communications https://t.co/zLy6Xk0JhA

Mar 31, 2023 · 1 like · 913 followers View post →

Maria Fernanda Gómez-Méndez

@mfegoz · X

RT @cell_club: The plant unique ESCRT component FREE1 regulates autophagosome closure https://t.co/XDIVolAptm

Mar 30, 2023 · 3 shares · 76 followers View post →

Takuya Norizuki

@T_Norizuki · X

RT @cell_club: The plant unique ESCRT component FREE1 regulates autophagosome closure https://t.co/XDIVolAptm

Mar 30, 2023 · 3 shares · 281 followers View post →

Cell Biology J-Club

@cell_club · X

The plant unique ESCRT component FREE1 regulates autophagosome closure https://t.co/XDIVolAptm

Mar 30, 2023 · 14 likes · 3 shares · 6,110 followers View post →