Nat Commun April 2023 PMID 37012232

Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.

Jennifer G Abelin, Erik J Bergstrom, Keith D Rivera, Hannah B Taylor, Susan Klaeger, Charles Xu, Eva K Verzani, C Jackson White, Hilina B Woldemichael, Maya Virshup, Meagan E Olive, Myranda Maynard, Stephanie A Vartany, Joseph D Allen, Kshiti Phulphagar

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Mentions

Peak: 4 in Apr 2023

across 2 sources since Apr 2023

Extended reach

7,900

potential audience

Total likes

Video views

Mentions per month

Apr 2023 – Jul 2023

Where it's discussed

X / Twitter4 posts
YouTube1 videos

AI synopsis

What people are saying

The discussions emphasize the workflow's innovative ability to analyze multiple protein modifications from limited tissue samples, with phrases like 'enabling comprehensive analysis' and 'improving efficiency.' The tone conveys a sense of importance and potential, with some posts referring to it as a 'significant advancement' that could impact cancer research and proteomics, reflecting a positive but measured response to the publication.

AgreementModerate agreement

Most discussions recognize the workflow as a significant advancement in proteomic analysis, showing support for its utility.

InterestModerate interest

Participants display moderate interest, with mentions of its applications and potential, but lacking deep curiosity or skepticism.

EngagementNeutral engagement

While some posts share enthusiasm and highlight key features, they do not delve into detailed critique or extensive debate.

ImpactHigh impact

The posts suggest that this workflow could profoundly influence future research, as indicated by terms like 'game-changing' and references to its broad applications.

Abstract in brief

The MONTE workflow is a new method that allows comprehensive analysis of multiple protein-related data types—such as the immunopeptidome, ubiquitylome, proteome, phosphoproteome, and acetylome—from the same tissue sample, improving efficiency and depth of research.
Unlike previous methods, MONTE enables serial processing of these different omics without needing separate samples or protocols, ensuring that data quality and coverage are maintained.
The workflow has been tested on lung cancer samples, showing it can identify important peptides related to cancer, including those from tumor-specific antigens and neoantigens, which could be useful for understanding disease and developing treatments.]

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All mentions

Deep Scale Multi-Omics Workflow for Limited Tissue Samples in Cancer Research

The MONTE workflow enables comprehensive analysis of immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome from limited tissue samples, enhancing research efficiency and depth, demonstrated on lung…

STEM RTCL TV · Jul 25, 2023 29 views

Cristina C. Clement MS PhD

@us_ccClement · X

RT @PastelBio: Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limit…

Apr 10, 2023 · 3 shares · 133 followers View post →

Teck Yew Low

@TeckYew · X

RT @PastelBio: Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limit…

Apr 9, 2023 · 3 shares · 374 followers View post →

Pastel BioScience

@PastelBio · X

Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues | https://t.co/8Y0UWRhFXC #proteomics https://t.co/E4HGu0hALD

Apr 9, 2023 · 7 likes · 3 shares · 5,377 followers View post →

Kermit Murray

@kermitmurray · X

Apr 3, 2023 · 1 like · 1,970 followers View post →