J Neurooncol April 2023 PMID 37046110

First-in-human sonodynamic therapy with ALA for pediatric diffuse intrinsic pontine glioma: a phase 1/2 study using low-intensity focused ultrasound : Technical communication.

Hasan R Syed, Lindsay Kilburn, Adriana Fonseca, Javad Nazarian, Chima Oluigbo, John S Myseros, Roger J Packer, Robert F Keating

Mentions

41
Peak: 7 in May 2023
across 3 sources since Apr 2023

Extended reach

55,036
potential audience

Total likes

60

Video views

99

Mentions per month

Apr 2023 – Sep 2025

Where it's discussed

  • News22 articles
  • X / Twitter15 posts
  • YouTube4 videos

AI synopsis

What people are saying

The discussions emphasize the critical nature of diffuse intrinsic pontine glioma, describing it as 'devastating' with 'limited options.' They express genuine interest in the trial by highlighting it as a 'first-in-human' study, and the tone reflects hope and optimism about the innovative sonodynamic therapy’s potential impact, illustrating deep engagement and recognition of its significance.

AgreementStrong agreement

All posts acknowledge the severity of diffuse intrinsic pontine glioma and recognize the potential of the new therapy, indicating strong consensus in support.

InterestHigh interest

The mentions of first-in-human trials and innovative treatment approaches demonstrate high curiosity and enthusiasm.

EngagementModerate engagement

Posts actively discuss the significance of the research and its implications, though some are more concise or informational.

ImpactHigh impact

The focus on trying novel treatments for such a devastating disease suggests that these discussions see this research as having high transformative potential.

Abstract in brief

  • This study explores a new treatment approach called sonodynamic therapy using ALA (Aminolevulinic Acid) combined with low-intensity focused ultrasound, aimed at pediatric diffuse intrinsic pontine glioma, a very aggressive brain tumor in children.
  • It reports the initial use of this therapy in humans, focusing on safety and feasibility as part of a phase 1/2 clinical trial.
  • The goal is to see if this innovative method can effectively target and treat the tumor while minimizing damage to surrounding healthy brain tissue.]

Top posts

Most liked on X and Bluesky
Journal of Neuro-Oncology
@JNeurooncol · X

Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor prognosis. Read about the ongoing first-in-human trial of sonodynamic therapy using ALA to treat these lesions at @ChildrensNatl: https://t.co/ZfynypknGN https://t.co/5erwDpAXV2

May 27, 2023 · 31 likes · 9 shares · 8,785 followers View post →
Journal of Neuro-Oncology
@JNeurooncol · X

Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor prognosis. Read about the ongoing first-in-human trial of sonodynamic therapy using ALA to treat these lesions at @ChildrensNatl: https://t.co/ZfynypkVwl https://t.co/3WiJP9TheY

Aug 1, 2023 · 13 likes · 3 shares · 8,785 followers View post →
Journal of Neuro-Oncology
@JNeurooncol · X

Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor prognosis. Read about the ongoing first-in-human trial of sonodynamic therapy using ALA to treat these lesions at @ChildrensNatl: https://t.co/ZfynypknGN https://t.co/1LPSCkr2JC

Apr 24, 2023 · 12 likes · 3 shares · 8,785 followers View post →
Andres F. Cardona
@AndresFCardonaZ · X

RT @JNeurooncol: Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor…

Apr 24, 2023 · 3 shares · 8,851 followers View post →
Amanda Haddock
@AmandaHaddock · X

RT @JNeurooncol: Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor…

May 27, 2023 · 9 shares · 7,584 followers View post →
Analiz Rodriguez MD, PhD, MBA, FAANS
@ARODMDPHD · X

RT @JNeurooncol: Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor…

Aug 2, 2023 · 3 shares · 6,573 followers View post →

All mentions

Analiz Rodriguez MD, PhD, MBA, FAANS
@ARODMDPHD · X

RT @JNeurooncol: Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor…

Aug 2, 2023 · 3 shares · 6,573 followers View post →
Anton
@Anton65529666 · X

RT @JNeurooncol: Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor…

Aug 2, 2023 · 3 shares · 3 followers View post →
Manuel Sánchez
@Spyrja7 · X

RT @JNeurooncol: Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor…

Aug 1, 2023 · 3 shares · 401 followers View post →
Journal of Neuro-Oncology
@JNeurooncol · X

Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor prognosis. Read about the ongoing first-in-human trial of sonodynamic therapy using ALA to treat these lesions at @ChildrensNatl: https://t.co/ZfynypkVwl https://t.co/3WiJP9TheY

Aug 1, 2023 · 13 likes · 3 shares · 8,785 followers View post →
Rahul Chowdhary
@Rahul_Onco · X

RT @JNeurooncol: Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor…

May 28, 2023 · 9 shares · 6 followers View post →
Adriana Fonseca
@DrAdriFonseca · X

RT @JNeurooncol: Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor…

May 27, 2023 · 9 shares · 289 followers View post →
Alexandre Escande
@ESCANDE_A · X

RT @JNeurooncol: Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor…

May 27, 2023 · 9 shares · 406 followers View post →
SwissDIPG
@PaskalevBoris · X

RT @JNeurooncol: Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor…

May 27, 2023 · 9 shares · 185 followers View post →
Amanda Haddock
@AmandaHaddock · X

RT @JNeurooncol: Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor…

May 27, 2023 · 9 shares · 7,584 followers View post →
Daniel Donoho, MD
@ddonoho · X

RT @JNeurooncol: Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor…

May 27, 2023 · 9 shares · 2,459 followers View post →
Journal of Neuro-Oncology
@JNeurooncol · X

Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor prognosis. Read about the ongoing first-in-human trial of sonodynamic therapy using ALA to treat these lesions at @ChildrensNatl: https://t.co/ZfynypknGN https://t.co/5erwDpAXV2

May 27, 2023 · 31 likes · 9 shares · 8,785 followers View post →
Gerardo CM
@cuamanigm · X

RT @JNeurooncol: Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor…

Apr 26, 2023 · 3 shares · 174 followers View post →
Adela
@adelapoite · X

RT @JNeurooncol: Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor…

Apr 25, 2023 · 3 shares · 1,258 followers View post →
Andres F. Cardona
@AndresFCardonaZ · X

RT @JNeurooncol: Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor…

Apr 24, 2023 · 3 shares · 8,851 followers View post →
Journal of Neuro-Oncology
@JNeurooncol · X

Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor with limited surgical treatment options and a poor prognosis. Read about the ongoing first-in-human trial of sonodynamic therapy using ALA to treat these lesions at @ChildrensNatl: https://t.co/ZfynypknGN https://t.co/1LPSCkr2JC

Apr 24, 2023 · 12 likes · 3 shares · 8,785 followers View post →
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