Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration.

Yousef Javanmardi, Ayushi Agrawal, Andrea Malandrino, Soufian Lasli, Michelle Chen, Somayeh Shahreza, Bianca Serwinski, Leila Cammoun, Ran Li, Mehdi Jorfi, Boris Djordjevic, Nicolas Szita, Fabian Spill, Sergio Bertazzo, Graham K Sheridan

June 2023 Adv Sci (Weinh)

Synopsis of Social media discussions

Throughout the discussions, commenters express support and curiosity about how mechanical forces influence cancer spread, using words like 'muscle their way' and phrases like 'describing biomechanics,' which show an active interest in the study's implications. The tone reflects respect for the research's significance, highlighting its potential impact on future cancer therapies and understanding of metastasis.

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Agreement
 Moderate agreement

Most discussions acknowledge the importance of the study, with some explicitly praising its contributions to understanding cancer metastasis.

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Interest
 High level of interest

The topics related to cancer cell mechanics and migration appear engaging to the audience, shown by enthusiastic reactions and mentions of the study in various contexts.

E
Engagement
 Moderate level of engagement

Posts reference specific aspects of the research, such as the mechanics involved and the biological implications, indicating active interest and understanding.

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Impact
 Moderate level of impact

Discussions suggest that the publication is seen as meaningful for advancing knowledge in cancer biology and potentially influencing future research or treatment strategies.

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Endothelium and Matrix Mechanics in Cancer Cell Transendothelial Migration

Endothelium and Matrix Mechanics in Cancer Cell Transendothelial Migration

Cancer cell extravasation involves stopping on the blood vessel lining and moving into tissues. The study highlights how the mechanical properties of the endothelium and subendothelial matrix influence cancer cell migration through blood vessel walls.

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September 19, 2023

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Abstract Synopsis

  • Cancer cell extravasation involves the cancer cells stopping on the blood vessel lining (endothelium) and then moving through it into tissues, a critical step in metastasis.
  • The study highlights that the mechanical properties of the endothelium and the subendothelial matrix significantly influence the ability of cancer cells to migrate through blood vessel walls.
  • Both the forces exerted by cancer cell protrusions and the contractile forces of endothelial cells play crucial roles in the success of transmigration, affecting where metastasis occurs.