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Adv Sci (Weinh) June 2023 PMID 37051804

Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration.

Yousef Javanmardi, Ayushi Agrawal, Andrea Malandrino, Soufian Lasli, Michelle Chen, Somayeh Shahreza, Bianca Serwinski, Leila Cammoun, Ran Li, Mehdi Jorfi, Boris Djordjevic, Nicolas Szita, Fabian Spill, Sergio Bertazzo, Graham K Sheridan

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Mentions

28
Peak: 17 in Apr 2023
across 3 sources since Apr 2023

Extended reach

1,303,861
potential audience

Total likes

67

Video views

77

Mentions per month

Apr 2023 – Mar 2024

Where it's discussed

  • X / Twitter24 posts
  • News3 articles
  • YouTube1 videos

AI synopsis

What people are saying

Throughout the discussions, commenters express support and curiosity about how mechanical forces influence cancer spread, using words like 'muscle their way' and phrases like 'describing biomechanics,' which show an active interest in the study's implications. The tone reflects respect for the research's significance, highlighting its potential impact on future cancer therapies and understanding of metastasis.

AgreementModerate agreement

Most discussions acknowledge the importance of the study, with some explicitly praising its contributions to understanding cancer metastasis.

InterestHigh interest

The topics related to cancer cell mechanics and migration appear engaging to the audience, shown by enthusiastic reactions and mentions of the study in various contexts.

EngagementModerate engagement

Posts reference specific aspects of the research, such as the mechanics involved and the biological implications, indicating active interest and understanding.

ImpactModerate impact

Discussions suggest that the publication is seen as meaningful for advancing knowledge in cancer biology and potentially influencing future research or treatment strategies.

Abstract in brief

  • Cancer cell extravasation involves the cancer cells stopping on the blood vessel lining (endothelium) and then moving through it into tissues, a critical step in metastasis.
  • The study highlights that the mechanical properties of the endothelium and the subendothelial matrix significantly influence the ability of cancer cells to migrate through blood vessel walls.
  • Both the forces exerted by cancer cell protrusions and the contractile forces of endothelial cells play crucial roles in the success of transmigration, affecting where metastasis occurs.
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CalvoLab
@calvo_lab · X

Glad to share our newest study with our collaborators @emadmoeen @kamm_lab, describing the biomechanics of how cancer cells escape from the bloodstream to invade other organs, published yesterday in Advanced Science https://t.co/BCRu9wIMpe

Apr 14, 2023 · 38 likes · 9 shares · 965 followers View post →
Rosario in Paris ᥫ᭡
@chayito09 · X

Fuentes: Artículo resumido y traducido: - https://t.co/M5rvNWyiHj - https://t.co/dvRvtgk1tA - https://t.co/wxnspLZPPH - https://t.co/RtlseQTf4w -https://t.co/QugKLttg0Q - https://t.co/qMVWaKbs8d - https://t.co/gEHlrmYRrE - https://t.co/NJqUWA6mFg https://t.co/0eapOSjlsV

Mar 1, 2024 · 22 likes · 4 shares · 75,501 followers View post →
Medical Xpress
@medical_xpress · X

How ##cancercells muscle their way into other organs @uclnews @advscinews https://t.co/LSavupN5YS https://t.co/CwXMQKsekx

Apr 13, 2023 · 6 likes · 7 shares · 173,000 followers View post →
Rene Sugar
@renesugar · X

Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration https://t.co/HAlggequRq

Apr 14, 2023 · 1 like · 3,951 followers View post →
Phys.org
@physorg_com · X

RT @medical_xpress: How ##cancercells muscle their way into other organs @uclnews @advscinews https://t.co/LSavupN5YS https://t.co/CwXMQKse…

Apr 13, 2023 · 7 shares · 1,023,878 followers View post →
Medical Xpress
@physorg_health · X

RT @medical_xpress: How ##cancercells muscle their way into other organs @uclnews @advscinews https://t.co/LSavupN5YS https://t.co/CwXMQKse…

Apr 13, 2023 · 7 shares · 7,104 followers View post →

All mentions

@victor_mrtnez
@victor_mrtnez · X

RT @chayito09: Fuentes: Artículo resumido y traducido: - https://t.co/M5rvNWyiHj - https://t.co/dvRvtgk1tA - https://t.co/wxnspLZPPH -…

Mar 1, 2024 · 4 shares · 487 followers View post →
ferminacevesd
@ferminacevesd · X

RT @chayito09: Fuentes: Artículo resumido y traducido: - https://t.co/M5rvNWyiHj - https://t.co/dvRvtgk1tA - https://t.co/wxnspLZPPH -…

Mar 1, 2024 · 4 shares · 2,685 followers View post →
Jorge ortega
@jaguarjmo · X

RT @chayito09: Fuentes: Artículo resumido y traducido: - https://t.co/M5rvNWyiHj - https://t.co/dvRvtgk1tA - https://t.co/wxnspLZPPH -…

Mar 1, 2024 · 4 shares · 64 followers View post →
Elsa T
@ElsaT5922 · X

RT @chayito09: Fuentes: Artículo resumido y traducido: - https://t.co/M5rvNWyiHj - https://t.co/dvRvtgk1tA - https://t.co/wxnspLZPPH -…

Mar 1, 2024 · 4 shares · 16 followers View post →
Rosario in Paris ᥫ᭡
@chayito09 · X

Fuentes: Artículo resumido y traducido: - https://t.co/M5rvNWyiHj - https://t.co/dvRvtgk1tA - https://t.co/wxnspLZPPH - https://t.co/RtlseQTf4w -https://t.co/QugKLttg0Q - https://t.co/qMVWaKbs8d - https://t.co/gEHlrmYRrE - https://t.co/NJqUWA6mFg https://t.co/0eapOSjlsV

Mar 1, 2024 · 22 likes · 4 shares · 75,501 followers View post →
KammLab
@kamm_lab · X

RT @calvo_lab: Glad to share our newest study with our collaborators @emadmoeen @kamm_lab, describing the biomechanics of how cancer cells…

May 5, 2023 · 9 shares · 1,059 followers View post →
Laura Quevedo
@lauriquepa · X

RT @calvo_lab: Glad to share our newest study with our collaborators @emadmoeen @kamm_lab, describing the biomechanics of how cancer cells…

May 2, 2023 · 9 shares · 186 followers View post →
NP AGARWAL世界一フォローを目指しますAiming best in world.
@np_grwl · X

RT @medical_xpress: How ##cancercells muscle their way into other organs @uclnews @advscinews https://t.co/LSavupN5YS https://t.co/CwXMQKse…

Apr 20, 2023 · 7 shares · 1,788 followers View post →
Grupo Genómica Funcional IBBTEC
@IBBTEC_Varela · X

RT @calvo_lab: Glad to share our newest study with our collaborators @emadmoeen @kamm_lab, describing the biomechanics of how cancer cells…

Apr 17, 2023 · 9 shares · 242 followers View post →
Jon Humphries
@JDHL18 · X

RT @calvo_lab: Glad to share our newest study with our collaborators @emadmoeen @kamm_lab, describing the biomechanics of how cancer cells…

Apr 15, 2023 · 9 shares · 2,505 followers View post →
Ashraf Saad, bridging Glycobiology and Oncology!
@AsAshraf123321 · X

RT @calvo_lab: Glad to share our newest study with our collaborators @emadmoeen @kamm_lab, describing the biomechanics of how cancer cells…

Apr 14, 2023 · 9 shares · 1,610 followers View post →
Javier Redondo
@jredondomunoz · X

RT @calvo_lab: Glad to share our newest study with our collaborators @emadmoeen @kamm_lab, describing the biomechanics of how cancer cells…

Apr 14, 2023 · 9 shares · 1,034 followers View post →
eharo84
@EndikaHaro · X

RT @calvo_lab: Glad to share our newest study with our collaborators @emadmoeen @kamm_lab, describing the biomechanics of how cancer cells…

Apr 14, 2023 · 9 shares · 68 followers View post →
Elena Rainero
@ERainero_lab · X

RT @calvo_lab: Glad to share our newest study with our collaborators @emadmoeen @kamm_lab, describing the biomechanics of how cancer cells…

Apr 14, 2023 · 9 shares · 1,507 followers View post →
CalvoLab
@calvo_lab · X

Glad to share our newest study with our collaborators @emadmoeen @kamm_lab, describing the biomechanics of how cancer cells escape from the bloodstream to invade other organs, published yesterday in Advanced Science https://t.co/BCRu9wIMpe

Apr 14, 2023 · 38 likes · 9 shares · 965 followers View post →
Ariakas Enoreth
@Aenoreth · X

Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration https://t.co/9apCN4Wfy5

Apr 14, 2023 · 1,009 followers View post →
Rene Sugar
@renesugar · X

Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration https://t.co/HAlggequRq

Apr 14, 2023 · 1 like · 3,951 followers View post →
serrgv
@serrgv · X

RT @medical_xpress: How ##cancercells muscle their way into other organs @uclnews @advscinews https://t.co/LSavupN5YS https://t.co/CwXMQKse…

Apr 13, 2023 · 7 shares · 148 followers View post →
Manu Gupta
@guptam108 · X

RT @medical_xpress: How ##cancercells muscle their way into other organs @uclnews @advscinews https://t.co/LSavupN5YS https://t.co/CwXMQKse…

Apr 13, 2023 · 7 shares · 1,088 followers View post →
Medical Xpress
@physorg_health · X

RT @medical_xpress: How ##cancercells muscle their way into other organs @uclnews @advscinews https://t.co/LSavupN5YS https://t.co/CwXMQKse…

Apr 13, 2023 · 7 shares · 7,104 followers View post →
Science X
@sciencex_com · X

RT @medical_xpress: How ##cancercells muscle their way into other organs @uclnews @advscinews https://t.co/LSavupN5YS https://t.co/CwXMQKse…

Apr 13, 2023 · 7 shares · 3,528 followers View post →
Phys.org
@physorg_com · X

RT @medical_xpress: How ##cancercells muscle their way into other organs @uclnews @advscinews https://t.co/LSavupN5YS https://t.co/CwXMQKse…

Apr 13, 2023 · 7 shares · 1,023,878 followers View post →
Medical Xpress
@medical_xpress · X

How ##cancercells muscle their way into other organs @uclnews @advscinews https://t.co/LSavupN5YS https://t.co/CwXMQKsekx

Apr 13, 2023 · 6 likes · 7 shares · 173,000 followers View post →
plantregeneration
@plant_regenerat · X

Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration https://t.co/yopMqpztQ8

Apr 13, 2023 · 62 followers View post →