Front Endocrinol (Lausanne) July 2023 PMID 37056675

The crucial role and mechanism of insulin resistance in metabolic disease.

Xuefei Zhao, Xuedong An, Cunqing Yang, Wenjie Sun, Hangyu Ji, Fengmei Lian

Mentions

29
Peak: 19 in Mar 2023
across 3 sources since Mar 2023

Extended reach

137,060
potential audience

Total likes

257

Video views

58,169

Mentions per month

Mar 2023 – Aug 2025

Where it's discussed

  • X / Twitter23 posts
  • Facebook4 posts
  • YouTube2 videos

AI synopsis

What people are saying

Discussions highlight the article's focus on insulin resistance's role in diseases like diabetes and hypertension, with posts emphasizing mechanisms and therapeutic implications. Words like 'crucial', 'key', and phrases such as 'focus on mechanisms' reflect a serious and analytical tone, demonstrating their importance and interest in advancing knowledge.

AgreementModerate agreement

Most discussions acknowledge the importance of insulin resistance in metabolic diseases, reflecting a consensus on its foundational role.

InterestHigh interest

The posts demonstrate high interest by emphasizing various aspects of the research, including mechanisms, etiology, and therapeutic approaches.

EngagementModerate engagement

Posts engage with the topic through referencing mechanisms, diseases, and implications, showing thoughtful consideration rather than superficial reactions.

ImpactModerate impact

The discussions suggest the research influences understanding of metabolic conditions and highlights potential avenues for treatment, indicating a moderate impact.

Abstract in brief

  • Insulin resistance (IR) is a key factor in the development of metabolic diseases like diabetes, obesity, and fatty liver, and it involves abnormalities in insulin signaling pathways caused by genetics, lifestyle, inflammation, and other bodily conditions.
  • The mechanisms behind IR include issues such as insulin receptor problems, inflammation, hypoxia, lipotoxicity, and immune system disturbances, which collectively impair metabolic functions and organ health.
  • Current treatments focus on lifestyle changes like exercise and diet, medications such as biguanides and GLP-1, and traditional Chinese medicine; however, more research is needed to discover specific biomarkers and develop more targeted therapies to better manage multiple metabolic diseases holistically.

Top posts

Most liked on X and Bluesky
htw
@heniek_htw · X

The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key role of IR in a variety of metabolic diseases at multiple levels, including etiology, mechanisms and therapeutic approaches. https://t.co/vfWRRLaW7w https://t.co/N2Q881eNXy

Mar 29, 2023 · 27 likes · 18 shares · 11,364 followers View post →
Frontiers - Endocrinology
@FrontEndocrinol · X

New Research: The crucial role and mechanism of insulin resistance in metabolic disease: Insulin resistance (IR) plays a crucial role in the development and progression of metabolism-related diseases such as diabetes, hypertension,… https://t.co/CbJjOQTQxv #Endocrinology #Endo

Mar 28, 2023 · 1 like · 5,050 followers View post →
Longevity
@LongevityTao · X

Frontiers | The crucial role and mechanism of insulin resistance in metabolic disease https://t.co/idIN7hduI1

Aug 3, 2025 · 1 like · 331 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 29, 2023 · 18 shares · 32,579 followers View post →
Javi Ciborro
@papayaykware · X

https://t.co/myHsBLiqtt El papel crucial y el mecanismo de la resistencia a la insulina en la enfermedad metabólica.

Oct 4, 2023 · 8,034 followers View post →
Fundación Iberoamericana de Nutrición
@FinutOrg · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 30, 2023 · 18 shares · 4,047 followers View post →

All mentions

Longevity
@LongevityTao · X

Frontiers | The crucial role and mechanism of insulin resistance in metabolic disease https://t.co/idIN7hduI1

Aug 3, 2025 · 1 like · 331 followers View post →
Javi Ciborro
@papayaykware · X

https://t.co/myHsBLiqtt El papel crucial y el mecanismo de la resistencia a la insulina en la enfermedad metabólica.

Oct 4, 2023 · 8,034 followers View post →
Dr. Adarsh Jha
@DrAdarshJha1 · X

The crucial role and mechanism of insulin resistance in metabolic disease https://t.co/EkmN3CDdfD

May 2, 2023 View post →
NASH/NAFLD
@NNafld · X

The crucial role and mechanism of insulin resistance in metabolic disease https://t.co/UVHNN9SaBq

Apr 15, 2023 · 91 followers View post →
Mohamed omar Elfarok
@Mohamed01793348 · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 31, 2023 · 18 shares · 674 followers View post →
_MCRicardo_
@_MCRicardo_ · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 30, 2023 · 18 shares · 2,117 followers View post →
Dr.Shashikant Singh
@Shashi2210 · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 30, 2023 · 18 shares · 2,667 followers View post →
Kanagavel
@krnk02 · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 30, 2023 · 18 shares · 596 followers View post →
Fundación Iberoamericana de Nutrición
@FinutOrg · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 30, 2023 · 18 shares · 4,047 followers View post →
Wilhelm Beermann
@WilhelmBeermann · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 30, 2023 · 18 shares · 127 followers View post →
Ricardo bernal sanch
@Ricardobernals1 · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 30, 2023 · 18 shares · 189 followers View post →
Jeffrey Gross, M.D.
@DrJeffreyGross · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 29, 2023 · 18 shares · 47 followers View post →
Hector
@Hector63433971 · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 29, 2023 · 18 shares · 46 followers View post →
HUGO COLOMBO MD
@HCOLOMBO1958 · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 29, 2023 · 18 shares · 1,121 followers View post →
Madrynha2024
@madrynha2012 · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 29, 2023 · 18 shares · 3,196 followers View post →
DrRPalmquist
@DrPalmquist · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 29, 2023 · 18 shares · 3,167 followers View post →
Javed Alam
@jalam1001 · X

https://t.co/19Q5WuMmKm #ir #insulin #Resistance

Mar 29, 2023 · 1,004 followers View post →
Oscar Andres
@OscarAndresMD · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 29, 2023 · 18 shares · 549 followers View post →
Bayar Jaff
@JaffBayar · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 29, 2023 · 18 shares · 607 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 29, 2023 · 18 shares · 32,579 followers View post →
Sagittarius
@guani_vic · X

RT @heniek_htw: The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key…

Mar 29, 2023 · 18 shares · 677 followers View post →
htw
@heniek_htw · X

The crucial role and mechanism of #insulin resistance in #metabolic disease The aim of this review is to focus on the key role of IR in a variety of metabolic diseases at multiple levels, including etiology, mechanisms and therapeutic approaches. https://t.co/vfWRRLaW7w https://t.co/N2Q881eNXy

Mar 29, 2023 · 27 likes · 18 shares · 11,364 followers View post →
Frontiers - Endocrinology
@FrontEndocrinol · X

New Research: The crucial role and mechanism of insulin resistance in metabolic disease: Insulin resistance (IR) plays a crucial role in the development and progression of metabolism-related diseases such as diabetes, hypertension,… https://t.co/CbJjOQTQxv #Endocrinology #Endo

Mar 28, 2023 · 1 like · 5,050 followers View post →