Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis.

Wei Luo, Guang Xu, Zheng Song, Wenqing Mu, Jincai Wen, Siwen Hui, Jia Zhao, Xiaoyan Zhan, Zhaofang Bai, Xiaohe Xiao

April 2023 Front Pharmacol

Synopsis of Social media discussions

The discussions primarily highlight the key findings that licorice extract inhibits the cGAS-STING pathway, with phrases like 'new research' and 'protects against NASH' indicating curiosity and recognition of therapeutic promise. The tone is neutral to mildly optimistic, focusing on the new scientific insight rather than in-depth analysis or critique.

A
Agreement
 Moderate agreement

Most discussions acknowledge the study's findings that licorice extract can inhibit the cGAS-STING pathway and potentially treat NASH, showing moderate support.

I
Interest
 Moderate level of interest

Participants display a general curiosity about the research, mainly emphasizing the novelty of the findings without deep exploration.

E
Engagement
 Moderate level of engagement

Comments show some engagement through mentions of the pathway and potential therapeutic effects, but lack detailed analysis or critique.

I
Impact
 Neutral impact

The discussions recognize the potential importance of the study but do not demonstrate widespread anticipation of immediate clinical change.

Social Mentions

YouTube

2 Videos

Twitter

6 Posts

Metrics

Video Views

261

Total Likes

32

Extended Reach

49,062

Social Features

8

Timeline: Posts about article

Top Social Media Posts

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  • Ramucho67
    @ramucho67 (Twitter)

    RT @FrontPharmacol: New Research: Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https…
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    May 19, 2024

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  • Nick Petosky
    @pizzapicklespur (Twitter)

    RT @FrontPharmacol: New Research: Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https…
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    May 19, 2024

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  • Bocquet Annelise
    @AnneliseBocquet (Twitter)

    RT @FrontPharmacol: New Research: Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https…
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    May 19, 2024

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  • Good Luck
    @GoodLuck_BSafe (Twitter)

    Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https://t.co/XVsnUjA7Pm https://t.co/LaMDtVSkDA
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    April 25, 2024

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  • Fábio Fonseca
    @FbioFon84085623 (Twitter)

    RT @FrontPharmacol: New Research: Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https…
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    April 4, 2023

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  • Frontiers - Pharmacology and Toxicology
    @FrontPharmacol (Twitter)

    New Research: Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https://t.co/GtWOuqNODH #pharmacology
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    April 4, 2023

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Abstract Synopsis

  • Inflammation and fibrosis are key symptoms of non-alcoholic steatohepatitis (NASH), a common chronic liver disease, and the cGAS-STING signaling pathway is involved in its progression.
  • This study examined the effects of licorice extract on the cGAS-STING pathway using bone marrow-derived macrophages and an MCD diet-induced NASH mouse model, showing that licorice can inhibit pathway activation and reduce liver inflammation and fibrosis.
  • Licorice extract may serve as a potential therapeutic option for NASH, demonstrating similar effects whether used alone or in combination with the STING inhibitor C-176.