Front Pharmacol April 2023 PMID 37081966

Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis.

Wei Luo, Guang Xu, Zheng Song, Wenqing Mu, Jincai Wen, Siwen Hui, Jia Zhao, Xiaoyan Zhan, Zhaofang Bai, Xiaohe Xiao

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Mentions

8
Peak: 4 in May 2024
across 2 sources since Apr 2023

Extended reach

49,062
potential audience

Total likes

32

Video views

261

Mentions per month

Apr 2023 – Jun 2024

Where it's discussed

  • X / Twitter6 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions primarily highlight the key findings that licorice extract inhibits the cGAS-STING pathway, with phrases like 'new research' and 'protects against NASH' indicating curiosity and recognition of therapeutic promise. The tone is neutral to mildly optimistic, focusing on the new scientific insight rather than in-depth analysis or critique.

AgreementModerate agreement

Most discussions acknowledge the study's findings that licorice extract can inhibit the cGAS-STING pathway and potentially treat NASH, showing moderate support.

InterestModerate interest

Participants display a general curiosity about the research, mainly emphasizing the novelty of the findings without deep exploration.

EngagementModerate engagement

Comments show some engagement through mentions of the pathway and potential therapeutic effects, but lack detailed analysis or critique.

ImpactNeutral impact

The discussions recognize the potential importance of the study but do not demonstrate widespread anticipation of immediate clinical change.

Abstract in brief

  • Inflammation and fibrosis are key symptoms of non-alcoholic steatohepatitis (NASH), a common chronic liver disease, and the cGAS-STING signaling pathway is involved in its progression.
  • This study examined the effects of licorice extract on the cGAS-STING pathway using bone marrow-derived macrophages and an MCD diet-induced NASH mouse model, showing that licorice can inhibit pathway activation and reduce liver inflammation and fibrosis.
  • Licorice extract may serve as a potential therapeutic option for NASH, demonstrating similar effects whether used alone or in combination with the STING inhibitor C-176.

Top posts

Most liked on X and Bluesky
Frontiers - Pharmacology and Toxicology
@FrontPharmacol · X

New Research: Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https://t.co/GtWOuqNODH #pharmacology

Apr 4, 2023 · 10 likes · 4 shares · 6,111 followers View post →
Good Luck
@GoodLuck_BSafe · X

Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https://t.co/XVsnUjA7Pm https://t.co/LaMDtVSkDA

Apr 25, 2024 · 1 like · 237 followers View post →
Bocquet Annelise
@AnneliseBocquet · X

RT @FrontPharmacol: New Research: Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https…

May 19, 2024 · 4 shares · 29,384 followers View post →
Nick Petosky
@pizzapicklespur · X

RT @FrontPharmacol: New Research: Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https…

May 19, 2024 · 4 shares · 10,568 followers View post →
Ramucho67
@ramucho67 · X

RT @FrontPharmacol: New Research: Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https…

May 19, 2024 · 4 shares · 1,876 followers View post →
Fábio Fonseca
@FbioFon84085623 · X

RT @FrontPharmacol: New Research: Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https…

Apr 4, 2023 · 4 shares · 585 followers View post →

All mentions

Ramucho67
@ramucho67 · X

RT @FrontPharmacol: New Research: Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https…

May 19, 2024 · 4 shares · 1,876 followers View post →
Nick Petosky
@pizzapicklespur · X

RT @FrontPharmacol: New Research: Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https…

May 19, 2024 · 4 shares · 10,568 followers View post →
Bocquet Annelise
@AnneliseBocquet · X

RT @FrontPharmacol: New Research: Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https…

May 19, 2024 · 4 shares · 29,384 followers View post →
Good Luck
@GoodLuck_BSafe · X

Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https://t.co/XVsnUjA7Pm https://t.co/LaMDtVSkDA

Apr 25, 2024 · 1 like · 237 followers View post →
Fábio Fonseca
@FbioFon84085623 · X

RT @FrontPharmacol: New Research: Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https…

Apr 4, 2023 · 4 shares · 585 followers View post →
Frontiers - Pharmacology and Toxicology
@FrontPharmacol · X

New Research: Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis https://t.co/GtWOuqNODH #pharmacology

Apr 4, 2023 · 10 likes · 4 shares · 6,111 followers View post →