Immune cell dynamics deconvoluted by single-cell RNA sequencing in normothermic machine perfusion of the liver.

T Hautz, S Salcher, M Fodor, G Sturm, S Ebner, A Mair, M Trebo, G Untergasser, S Sopper, B Cardini, A Martowicz, J Hofmann, S Daum, M Kalb, T Resch

April 2023 Nat Commun

Synopsis of Social media discussions

Discussions highlight the importance of findings such as neutrophil shifts and macrophage activation, often emphasizing the potential for better organ preservation strategies. The tone varies from enthusiastic to analytical, reflecting genuine interest in how single-cell RNA sequencing can advance transplantation science.

A
Agreement
 Moderate agreement

Most discussions acknowledge the significance of the study in understanding immune responses during liver preservation.

I
Interest
 High level of interest

Participants show high curiosity, engaging actively with the complexities of immune cell behavior and techniques used.

E
Engagement
 Moderate level of engagement

Comments include detailed references to immune cell shifts and potential clinical implications, indicating thoughtful engagement.

I
Impact
 Moderate level of impact

The discussions suggest the study could influence future research and practices in organ transplantation, though it's still early to gauge widespread impact.

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Posts referencing the article

Immune Cell Dynamics in Liver Preservation Revealed by Single-Cell RNA Sequencing

Immune Cell Dynamics in Liver Preservation Revealed by Single-Cell RNA Sequencing

This study used single-cell RNA sequencing to analyze immune cell changes during normothermic machine perfusion of the liver, showing a decrease in neutrophils and an increase in anti-inflammatory monocytes and macrophages over time.

STEM RTCL TV

July 22, 2023

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    New from #FWFOpenAccess https://t.co/xy1A7pyPmj Immune cell dynamics deconvoluted by single-cell RNA sequencing in normothermic machine perfusion of the liver.
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    April 25, 2023

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Abstract Synopsis

  • The study used single-cell RNA sequencing to analyze immune cell changes in donor livers during normothermic machine perfusion (NMP), revealing a decrease in neutrophils and an increase in anti-inflammatory monocytes/macrophages over time.
  • Neutrophils initially present in a proinflammatory state shift towards a more aged and exhausted phenotype during NMP, accompanied by a large efflux of passenger leukocytes, especially neutrophils, into the perfusate.
  • These immune cell dynamics, including shifts in phenotypes and cell populations, may influence inflammatory responses during liver preservation and could inform future immune-targeting interventions.]