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Nat Commun April 2023 PMID 37085477

Immune cell dynamics deconvoluted by single-cell RNA sequencing in normothermic machine perfusion of the liver.

T Hautz, S Salcher, M Fodor, G Sturm, S Ebner, A Mair, M Trebo, G Untergasser, S Sopper, B Cardini, A Martowicz, J Hofmann, S Daum, M Kalb, T Resch

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Mentions

5
Peak: 4 in Apr 2023
across 2 sources since Apr 2023

Extended reach

11,670
potential audience

Total likes

9

Video views

6

Mentions per month

Apr 2023 – Jul 2023

Where it's discussed

  • X / Twitter4 posts
  • YouTube1 videos

AI synopsis

What people are saying

Discussions highlight the importance of findings such as neutrophil shifts and macrophage activation, often emphasizing the potential for better organ preservation strategies. The tone varies from enthusiastic to analytical, reflecting genuine interest in how single-cell RNA sequencing can advance transplantation science.

AgreementModerate agreement

Most discussions acknowledge the significance of the study in understanding immune responses during liver preservation.

InterestHigh interest

Participants show high curiosity, engaging actively with the complexities of immune cell behavior and techniques used.

EngagementModerate engagement

Comments include detailed references to immune cell shifts and potential clinical implications, indicating thoughtful engagement.

ImpactModerate impact

The discussions suggest the study could influence future research and practices in organ transplantation, though it's still early to gauge widespread impact.

Abstract in brief

  • The study used single-cell RNA sequencing to analyze immune cell changes in donor livers during normothermic machine perfusion (NMP), revealing a decrease in neutrophils and an increase in anti-inflammatory monocytes/macrophages over time.
  • Neutrophils initially present in a proinflammatory state shift towards a more aged and exhausted phenotype during NMP, accompanied by a large efflux of passenger leukocytes, especially neutrophils, into the perfusate.
  • These immune cell dynamics, including shifts in phenotypes and cell populations, may influence inflammatory responses during liver preservation and could inform future immune-targeting interventions.]
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Top posts

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Stefan Salcher
@SalcherStefan · X

Apr 24, 2023 · 9 likes · 2 shares · 136 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @SalcherStefan:

Apr 24, 2023 · 2 shares · 8,159 followers View post →
Transcriptomes
@transcriptomes · X

Immune cell dynamics deconvoluted by single-cell RNA sequencing in normothermic machine perfu... https://t.co/AH3F3N52Tq

Apr 22, 2023 · 1,809 followers View post →
Europe PMC articles
@EuropePMC · X

New from #FWFOpenAccess https://t.co/xy1A7pyPmj Immune cell dynamics deconvoluted by single-cell RNA sequencing in normothermic machine perfusion of the liver.

Apr 25, 2023 · 1,552 followers View post →

All mentions

Europe PMC articles
@EuropePMC · X

New from #FWFOpenAccess https://t.co/xy1A7pyPmj Immune cell dynamics deconvoluted by single-cell RNA sequencing in normothermic machine perfusion of the liver.

Apr 25, 2023 · 1,552 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @SalcherStefan:

Apr 24, 2023 · 2 shares · 8,159 followers View post →
Stefan Salcher
@SalcherStefan · X

Apr 24, 2023 · 9 likes · 2 shares · 136 followers View post →
Transcriptomes
@transcriptomes · X

Immune cell dynamics deconvoluted by single-cell RNA sequencing in normothermic machine perfu... https://t.co/AH3F3N52Tq

Apr 22, 2023 · 1,809 followers View post →