Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesgo de mortalidad de un 10-15 %, similar al efecto de la intervención para dejar de fumar #ayuno #restriccion #aging #ADN #envejecimiento https://t.co/MrRMseLG3l https://t.co/zPkul4G2qP
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.
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Sep 2021 – Oct 2026Where it's discussed
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AI synopsis
What people are saying
Overall, the discussion centers on the CALERIE trial findings that long-term caloric restriction modestly slows biological aging as measured by certain epigenetic clocks (e.g., DunedinPACE) while not substantially altering other age estimates. Participants commonly acknowledge the small effect sizes and stress the need for longer-term, outcome-based studies to determine real health benefits. The tone mixes cautious optimism with critical nuance, citing methodological limits, clock-specific effects, and the gap between molecular markers and actual disease risk or lifespan. Word choices like slowed pace of aging, minimal/2-3% changes, and references to clocks support a narrative of preliminary but promising evidence that invites further research and careful interpretation.
Most posts acknowledge that CR may slow aging markers but emphasize small effect sizes and uncertainty about broader health outcomes, showing cautious agreement.
Posts show curiosity and relevance, with multiple mentions of mechanisms, clocks, and practical implications, indicating solid interest.
Responses are more than cursory retweets; many comment on specific findings, limitations, or translate results for broader audiences, signaling moderate to deep engagement.
The potential for modest impact on aging biology is highlighted, with caveats about extrapolating to healthspan; several posts frame it as interesting but not conclusive.
Abstract in brief
- The study investigated how long-term caloric restriction (CR) impacts DNA methylation markers of biological aging in healthy adults, finding that CR slowed down the pace of aging according to the DunedinPACE measure, but did not significantly change other biological age estimates.
- The research supports the geroscience hypothesis, suggesting that interventions like CR can potentially delay molecular aging processes and improve health span, although the effect sizes were small.
- To definitively confirm if CR truly extends healthy lifespan and prevents chronic diseases, longer-term studies are needed that track actual health outcomes, such as disease incidence and mortality, beyond just molecular markers.
Top posts
Most liked on X and BlueskyEffect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial R. Waziry, C. P. Ryan, @Danbelsky & coauthors https://t.co/3nRe7fk0fc @NatureAging https://t.co/90sxU7tP2U
https://t.co/EHPDx6ira6
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/bkXjO4JQp4
Effect of Long-Term Caloric Restriction on DNA Methylation Measures of Biological Aging in Healthy Adults: CALERIE™ Trial Analysis https://t.co/jrUUDZrUfC @biorxivpreprint “CALERIE intervention slowed Pace of Aging but showed minimal effect on epigenetic clocks..[GrimAge et]
■参考文献■ Nature Aging: 09 Feb, 2023 DOI: 10.1038/s43587-022-00357-y
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We are the last generation that will accept “you should have come in sooner” as an explanation. 7 real breakthroughs, 7 beliefs, and the hard truths nobody likes to post about. Full piece below. https://t.co/mhJUu1FZJQ
?ご紹介した論文(PubMed)はこちら: https://t.co/GYjwDvdGiZ
? カロリー制限はヒトの「老化速度」を変えるのか——CALERIE試験の深掘りです 「腹八分目」を科学で検証した、現時点で最も本格的な臨床試験を紹介します。肥満でない健康な成人220人を「25%カロリー制限」群と「自由摂取」群に無作為に分け、2年間追跡した米国のRCTです。 ? Waziry R, et al. https://t.co/WDEVQkPAij
CALERIE: a small DunedinPACE change, but no significant PhenoAge/GrimAge change. A clock response alone does not prove longer life. Nature Aging (2023) pubmed.ncbi.nlm.nih.gov/37118425/ AI-assisted. Educational, not medical advice.
Gen bukanlah sesuatu yang statis; melainkan dinamis dan dapat dipengaruhi oleh lingkungan serta gaya hidup. https://t.co/dLEwFq8Trd EPIGENETIK - Rahasia Mengendalikan Gen untuk Hidup Lebih Panjang dan Sehat - Klinik Dokter Rocky https://t.co/6nwZCSFbdx
https://t.co/EHPDx6ira6
Sources: Waziry R, Ryan CP, Corcoran DL, et al. Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. Nature Aging. 2023;3:248–257. https://t.co/xZjMSFMd7O Kraus WE, Bhapkar M, Huffman KM, et al. 2
진짜 동결건조되는 젊어지는 방법 공개 미국에서 무려 2년 동안 건강한 성인들을 대상으로 칼로리 제한 그룹 vs 일반 식단 그룹 나눠서 하루 섭취 열량을 줄이는 실험을 함. 그랬더니 칼로리 섭취를 25% 줄인 그룹에서 단순히 체중이 줄어든게 아니라 > 생물학적 노화가 느려짐 < *출처: Effect of https://t.co/0GFs6XCGc7
In humans, calorie restriction slows biological aging pace by ~2–3% over 2 years (CALERIE trial) www.nature.com/articles/s43...
Slowed pace of aging as measured by the DunedinPACE epigenetic clock, but no effect on the GrimAge, PhenoAge, or first-generation clocks www.nature.com/articles/s43...
Longevity pills, or simply eat a little less? A new study (Nature Aging) shows that cutting 12% of your calorie intake for 2y slows aging by 1-2%, reversing age-related molecular changes. Small adjustments, but good news is they add up over time. https://t.co/DtdmlODHwm
@drimtiaz1955 Yes, there's pretty good evidence that calorie restriction slows aging. A recent study found that reducing caloric intake by 25% over 2 years slowed the pace of biological aging by 2-3% in healthy adults, as measured by certain epigenetic biomarkers. https://t.co/yOvk9uwwqN
https://t.co/w3QFs8kOKe
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial | Nature Aging https://t.co/AZGC7FJZEQ
@Danbelsky We also discuss the effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesgo de mortalidad de un 10-15 %, similar al efecto de la intervención para dejar de fumar #ayuno #restriccion #aging #ADN #envejecimiento https://t.co/MrRMseLG3l https://t.co/zPkul4G2qP
Author Correction: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/8hxHYkyCUR https://t.co/alolQUtUUK
"Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial." Nat Aging 3, 248–257 (2023). https://t.co/ukuBwl8qrd @brunovellas @isaperarnau @InfinityTLS @RestoreInstitut @I2mcT
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial | Nature Aging https://t.co/DKEH7g0Zp8
RT @KidneyInCVD: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE…
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial | Nature Aging https://t.co/otz4PVFft7
@KarlPfleger @mike_lustgarten @olafurpall80 @bryan_johnson Clock ages at baseline are all over the place https://t.co/PwX1nQbawH
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/39IwlBS1Lw https://t.co/lSdYlsDeM7
Letter Open Access Published: 09 February 2023 Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/Um03IgW1Sf
RT @nikmarino9: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE…
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/ZGju8CTB19
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/x0JR0lChlS via @Nature
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. https://t.co/JwJJcoFFJr
Open Access: Waziry, R., Ryan, C.P., Corcoran, D.L. et al. Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. Nat Aging (2023). https://t.co/jaIdc5ofuD
■参考文献■ Nature Aging: 09 Feb, 2023 DOI: 10.1038/s43587-022-00357-y
link: https://t.co/9cfgpcJcLx ⚕️
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/HXRA4VI4yk
link: https://t.co/9cfgpcJcLx ⚕️
元論文→ Reference: Waziry R, Ryan CP, Corcoran DL, et al. Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. Nat. Aging. 2023. doi: 10.1038/s43587-022-00357-y. https://t.co/lhCMbU4BQJ
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From @TIME IG post: ••• This new study demonstrates that calorie restriction may slow #aging in humans. Waziry, R., Ryan, C.P., Corcoran, D.L. et al. CALERIE trial. Nat Aging (2023). https://t.co/sUO6FAOXrv
RT @JHUCIDNI: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE tr…
RT @AgingBiology: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERI…
link: https://t.co/9cfgpcJcLx ⚕️
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial | Nature Aging https://t.co/jEtvjYHGgF
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RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
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RT @sarekore: 老化速度を表す動的な指標において、カロリー制限は老化速度を2~3%遅らせることがわかりました。他の研究によれば、これは死亡リスクの10~15%の減少に相当し、禁煙と同様の効果です。ただし他の2つの静的な老化指標(生物年齢)では老化を遅らせる効果は認め…
老化速度を表す動的な指標において、カロリー制限は老化速度を2~3%遅らせることがわかりました。他の研究によれば、これは死亡リスクの10~15%の減少に相当し、禁煙と同様の効果です。ただし他の2つの静的な老化指標(生物年齢)では老化を遅らせる効果は認められませんでしたhttps://t.co/wSiXPnTWZd
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RT @AgingBiology: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERI…
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RT @AgingBiology: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERI…
link: https://t.co/9cfgpcJcLx ⚕️
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RT @AgingBiology: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERI…
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/bkXjO4JQp4
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RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
RT @nick_krontiris: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALE…
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (open access) https://t.co/Lcjrmr9dpg #aging #longevity
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/f9b2JcIsO5
RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial | Nature Aging. https://t.co/ibLceIX4vp
RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial R. Waziry, C. P. Ryan, @Danbelsky & coauthors https://t.co/3nRe7fk0fc @NatureAging https://t.co/90sxU7tP2U
RT @agingdoc1: Great overview @Danbelsky @metabesity today. We would do well incentivizing optimal lifestyle practices via structure & poli…
Great overview @Danbelsky @metabesity today. We would do well incentivizing optimal lifestyle practices via structure & policy initiatives
RT @agingdoc1: Effect of Long-Term Caloric Restriction on DNA Methylation Measures of Biological Aging in Healthy Adults: CALERIE™ Trial An…
Effect of Long-Term Caloric Restriction on DNA Methylation Measures of Biological Aging in Healthy Adults: CALERIE™ Trial Analysis https://t.co/jrUUDZrUfC @biorxivpreprint “CALERIE intervention slowed Pace of Aging but showed minimal effect on epigenetic clocks..[GrimAge et]
RT @medrxivpreprint: Effect of Long-Term Caloric Restriction on DNA Methylation Measures of Biological Aging in Healthy Adults: CALERIETM T…
Effect of Long-Term Caloric Restriction on DNA Methylation Measures of Biological Aging in Healthy Adults: CALERIETM Trial Analysis https://t.co/ML3cVZZ35s #medRxiv
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