Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesgo de mortalidad de un 10-15 %, similar al efecto de la intervención para dejar de fumar #ayuno #restriccion #aging #ADN #envejecimiento https://t.co/MrRMseLG3l https://t.co/zPkul4G2qP
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.
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Sep 2021 – Nov 2025Where it's discussed
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AI synopsis
What people are saying
The discussions highlight the key results, such as the slowing of biological aging by 2-3% through caloric restriction, emphasizing phrases like 'supports' and 'good news,' which convey positive perception. The tone is informative but cautious, reflecting interest in the scientific validity without overhyping immediate impact.
Most posts acknowledge the study’s findings supporting caloric restriction’s role in slowing aging, reflecting general agreement with its implications.
Discussions show high interest, with references to biological aging, epigenetic markers, and potential health benefits.
Posts include some references to the study’s methods and broader implications, indicating moderate engagement.
The collective tone suggests the findings are seen as relevant but not yet transformative for applying in mainstream health practices.
Abstract in brief
- The study investigated how long-term caloric restriction (CR) impacts DNA methylation markers of biological aging in healthy adults, finding that CR slowed down the pace of aging according to the DunedinPACE measure, but did not significantly change other biological age estimates.
- The research supports the geroscience hypothesis, suggesting that interventions like CR can potentially delay molecular aging processes and improve health span, although the effect sizes were small.
- To definitively confirm if CR truly extends healthy lifespan and prevents chronic diseases, longer-term studies are needed that track actual health outcomes, such as disease incidence and mortality, beyond just molecular markers.
Top posts
Most liked on X and BlueskyEffect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial R. Waziry, C. P. Ryan, @Danbelsky & coauthors https://t.co/3nRe7fk0fc @NatureAging https://t.co/90sxU7tP2U
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/bkXjO4JQp4
Effect of Long-Term Caloric Restriction on DNA Methylation Measures of Biological Aging in Healthy Adults: CALERIE™ Trial Analysis https://t.co/jrUUDZrUfC @biorxivpreprint “CALERIE intervention slowed Pace of Aging but showed minimal effect on epigenetic clocks..[GrimAge et]
■参考文献■ Nature Aging: 09 Feb, 2023 DOI: 10.1038/s43587-022-00357-y
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/ZGju8CTB19
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4 Key Rules for Healthy and Balanced Nutrition
Hello viewers, in this video, I discuss the importance of proper and balanced eating based on the 4 N rules. Enjoy watching and stay balanced and happy.
【科学的根拠】チートで若返る健康の雑学
Impact of Intermittent Fasting on Cellular Aging and Gene Expression
This study explores how prolonged intermittent fasting influences autophagy, inflammasome, and senescence gene expressions in healthy young males, providing insights into fasting's role in aging and cellular health.
Caloric Restriction and Longevity in Humans and Primates
Caloric restriction, or consuming slightly fewer calories than daily expenditure, has been shown to promote health and extend lifespan in rodents and primates. A recent study on healthy adults indicated that long-term…
Impact of Long-Term Caloric Restriction on Biological Aging Markers
This study investigates how long-term caloric restriction affects DNA methylation markers of biological aging in healthy adults, indicating a slowdown in the pace of aging, supporting the potential for delaying…
Calorie Restriction and Human Aging: Insights from the CALERIE Trial
This study investigated how long-term caloric restriction impacts DNA methylation markers of biological aging in healthy adults, finding that CR slowed molecular aging according to the DunedinPACE measure, but did not…
Longevity pills, or simply eat a little less? A new study (Nature Aging) shows that cutting 12% of your calorie intake for 2y slows aging by 1-2%, reversing age-related molecular changes. Small adjustments, but good news is they add up over time. https://t.co/DtdmlODHwm
@drimtiaz1955 Yes, there's pretty good evidence that calorie restriction slows aging. A recent study found that reducing caloric intake by 25% over 2 years slowed the pace of biological aging by 2-3% in healthy adults, as measured by certain epigenetic biomarkers. https://t.co/yOvk9uwwqN
https://t.co/w3QFs8kOKe
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial | Nature Aging https://t.co/AZGC7FJZEQ
@Danbelsky We also discuss the effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…
Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesgo de mortalidad de un 10-15 %, similar al efecto de la intervención para dejar de fumar #ayuno #restriccion #aging #ADN #envejecimiento https://t.co/MrRMseLG3l https://t.co/zPkul4G2qP
Author Correction: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/8hxHYkyCUR https://t.co/alolQUtUUK
"Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial." Nat Aging 3, 248–257 (2023). https://t.co/ukuBwl8qrd @brunovellas @isaperarnau @InfinityTLS @RestoreInstitut @I2mcT
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial | Nature Aging https://t.co/DKEH7g0Zp8
RT @KidneyInCVD: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE…
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial | Nature Aging https://t.co/otz4PVFft7
@KarlPfleger @mike_lustgarten @olafurpall80 @bryan_johnson Clock ages at baseline are all over the place https://t.co/PwX1nQbawH
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/39IwlBS1Lw https://t.co/lSdYlsDeM7
Letter Open Access Published: 09 February 2023 Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/Um03IgW1Sf
RT @nikmarino9: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE…
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/ZGju8CTB19
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/x0JR0lChlS via @Nature
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. https://t.co/JwJJcoFFJr
Open Access: Waziry, R., Ryan, C.P., Corcoran, D.L. et al. Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. Nat Aging (2023). https://t.co/jaIdc5ofuD
■参考文献■ Nature Aging: 09 Feb, 2023 DOI: 10.1038/s43587-022-00357-y
link: https://t.co/9cfgpcJcLx ⚕️
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/HXRA4VI4yk
link: https://t.co/9cfgpcJcLx ⚕️
元論文→ Reference: Waziry R, Ryan CP, Corcoran DL, et al. Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. Nat. Aging. 2023. doi: 10.1038/s43587-022-00357-y. https://t.co/lhCMbU4BQJ
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From @TIME IG post: ••• This new study demonstrates that calorie restriction may slow #aging in humans. Waziry, R., Ryan, C.P., Corcoran, D.L. et al. CALERIE trial. Nat Aging (2023). https://t.co/sUO6FAOXrv
RT @JHUCIDNI: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE tr…
RT @AgingBiology: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERI…
link: https://t.co/9cfgpcJcLx ⚕️
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial | Nature Aging https://t.co/jEtvjYHGgF
link: https://t.co/9cfgpcJcLx ⚕️
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RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
link: https://t.co/9cfgpcJcLx ⚕️
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RT @sarekore: 老化速度を表す動的な指標において、カロリー制限は老化速度を2~3%遅らせることがわかりました。他の研究によれば、これは死亡リスクの10~15%の減少に相当し、禁煙と同様の効果です。ただし他の2つの静的な老化指標(生物年齢)では老化を遅らせる効果は認め…
老化速度を表す動的な指標において、カロリー制限は老化速度を2~3%遅らせることがわかりました。他の研究によれば、これは死亡リスクの10~15%の減少に相当し、禁煙と同様の効果です。ただし他の2つの静的な老化指標(生物年齢)では老化を遅らせる効果は認められませんでしたhttps://t.co/wSiXPnTWZd
link: https://t.co/9cfgpcJcLx ⚕️
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RT @AgingBiology: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERI…
link: https://t.co/9cfgpcJcLx ⚕️
link: https://t.co/9cfgpcJcLx ⚕️
link: https://t.co/9cfgpcJcLx ⚕️
link: https://t.co/9cfgpcJcLx ⚕️
RT @AgingBiology: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERI…
link: https://t.co/9cfgpcJcLx ⚕️
link: https://t.co/9cfgpcJcLx ⚕️
link: https://t.co/9cfgpcJcLx ⚕️
link: https://t.co/9cfgpcJcLx ⚕️
RT @AgingBiology: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERI…
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/bkXjO4JQp4
link: https://t.co/9cfgpcJcLx ⚕️
link: https://t.co/9cfgpcJcLx ⚕️
link: https://t.co/9cfgpcJcLx ⚕️
RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
RT @nick_krontiris: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALE…
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (open access) https://t.co/Lcjrmr9dpg #aging #longevity
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/f9b2JcIsO5
RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial | Nature Aging. https://t.co/ibLceIX4vp
RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial R. Waziry, C. P. Ryan, @Danbelsky & coauthors https://t.co/3nRe7fk0fc @NatureAging https://t.co/90sxU7tP2U
RT @agingdoc1: Great overview @Danbelsky @metabesity today. We would do well incentivizing optimal lifestyle practices via structure & poli…
Great overview @Danbelsky @metabesity today. We would do well incentivizing optimal lifestyle practices via structure & policy initiatives
RT @agingdoc1: Effect of Long-Term Caloric Restriction on DNA Methylation Measures of Biological Aging in Healthy Adults: CALERIE™ Trial An…
Effect of Long-Term Caloric Restriction on DNA Methylation Measures of Biological Aging in Healthy Adults: CALERIE™ Trial Analysis https://t.co/jrUUDZrUfC @biorxivpreprint “CALERIE intervention slowed Pace of Aging but showed minimal effect on epigenetic clocks..[GrimAge et]
RT @medrxivpreprint: Effect of Long-Term Caloric Restriction on DNA Methylation Measures of Biological Aging in Healthy Adults: CALERIETM T…
Effect of Long-Term Caloric Restriction on DNA Methylation Measures of Biological Aging in Healthy Adults: CALERIETM Trial Analysis https://t.co/ML3cVZZ35s #medRxiv