Nat Aging March 2023 PMID 37118425

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.

R Waziry, C P Ryan, D L Corcoran, K M Huffman, M S Kobor, M Kothari, G H Graf, V B Kraus, W E Kraus, D T S Lin, C F Pieper, M E Ramaker, M Bhapkar, S K Das, L Ferrucci

Mentions

396
Peak: 70 in Feb 2023
across 6 sources since Sep 2021

Extended reach

481,564
potential audience

Total likes

456

Video views

7,415

Mentions per month

Sep 2021 – Nov 2025

Where it's discussed

  • News238 articles
  • X / Twitter124 posts
  • Blogs18 articles
  • YouTube6 videos
  • Reddit6 posts
  • Facebook4 posts

AI synopsis

What people are saying

The discussions highlight the key results, such as the slowing of biological aging by 2-3% through caloric restriction, emphasizing phrases like 'supports' and 'good news,' which convey positive perception. The tone is informative but cautious, reflecting interest in the scientific validity without overhyping immediate impact.

AgreementModerate agreement

Most posts acknowledge the study’s findings supporting caloric restriction’s role in slowing aging, reflecting general agreement with its implications.

InterestHigh interest

Discussions show high interest, with references to biological aging, epigenetic markers, and potential health benefits.

EngagementModerate engagement

Posts include some references to the study’s methods and broader implications, indicating moderate engagement.

ImpactModerate impact

The collective tone suggests the findings are seen as relevant but not yet transformative for applying in mainstream health practices.

Abstract in brief

  • The study investigated how long-term caloric restriction (CR) impacts DNA methylation markers of biological aging in healthy adults, finding that CR slowed down the pace of aging according to the DunedinPACE measure, but did not significantly change other biological age estimates.
  • The research supports the geroscience hypothesis, suggesting that interventions like CR can potentially delay molecular aging processes and improve health span, although the effect sizes were small.
  • To definitively confirm if CR truly extends healthy lifespan and prevents chronic diseases, longer-term studies are needed that track actual health outcomes, such as disease incidence and mortality, beyond just molecular markers.

Top posts

Most liked on X and Bluesky
IberianCitizen
@IberianCitizen · X

Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesgo de mortalidad de un 10-15 %, similar al efecto de la intervención para dejar de fumar #ayuno #restriccion #aging #ADN #envejecimiento https://t.co/MrRMseLG3l https://t.co/zPkul4G2qP

Jul 5, 2023 · 143 likes · 44 shares · 12,931 followers View post →
Agingdoc
@agingdoc1 · X

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial R. Waziry, C. P. Ryan, @Danbelsky & coauthors https://t.co/3nRe7fk0fc @NatureAging https://t.co/90sxU7tP2U

Feb 9, 2023 · 28 likes · 11 shares · 41,233 followers View post →
Aging Science News
@AgingBiology · X

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/bkXjO4JQp4

Feb 11, 2023 · 18 likes · 4 shares · 30,520 followers View post →
Agingdoc
@agingdoc1 · X

Effect of Long-Term Caloric Restriction on DNA Methylation Measures of Biological Aging in Healthy Adults: CALERIE™ Trial Analysis https://t.co/jrUUDZrUfC @biorxivpreprint “CALERIE intervention slowed Pace of Aging but showed minimal effect on epigenetic clocks..[GrimAge et]

Oct 9, 2021 · 13 likes · 1 share · 41,233 followers View post →
浅野拓
@asanotaku_09 · X

■参考文献■ Nature Aging: 09 Feb, 2023 DOI: 10.1038/s43587-022-00357-y

Feb 15, 2023 · 7 likes · 13,028 followers View post →
Nicola Marino
@nikmarino9 · X

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/ZGju8CTB19

Feb 18, 2023 · 5 likes · 1 share · 8,753 followers View post →

All mentions

juliaelfie
@juliaelfie · X

Longevity pills, or simply eat a little less? A new study (Nature Aging) shows that cutting 12% of your calorie intake for 2y slows aging by 1-2%, reversing age-related molecular changes. Small adjustments, but good news is they add up over time. https://t.co/DtdmlODHwm

Aug 21, 2024 · 4 followers View post →
Kristie Leong M.D.
@DrKristieLeong · X

@drimtiaz1955 Yes, there's pretty good evidence that calorie restriction slows aging. A recent study found that reducing caloric intake by 25% over 2 years slowed the pace of biological aging by 2-3% in healthy adults, as measured by certain epigenetic biomarkers. https://t.co/yOvk9uwwqN ‌

May 4, 2024 · 59,514 followers View post →
Alexandra Badea
@portokalh · X

https://t.co/w3QFs8kOKe

Feb 19, 2024 · 956 followers View post →
Desi Veleva
@Desi_Veleva24 · X

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial | Nature Aging https://t.co/AZGC7FJZEQ

Sep 21, 2023 · 202 followers View post →
Hannah Went
@EverythingEpi · X

@Danbelsky We also discuss the effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.

Jul 19, 2023 · 2 likes · 557 followers View post →
Adriakin ✝️
@RastyKiba · X

RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…

Jul 10, 2023 · 44 shares · 424 followers View post →
NutriAle_Coach
@NutriAle_Coach · X

RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…

Jul 7, 2023 · 44 shares · 1,557 followers View post →
Yennyfer Gil G
@yenny_2010 · X

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Thelma Garibay
@ThelmaGaribay4 · X

RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…

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Dani Ramos
@PaliativosTeam · X

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JULIO MANUEL VILLA FERNANDEZ
@JULIOMANUELVIL1 · X

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Ogmas Writers
@OgmasWriters · X

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Juanjo
@JuanKo75 · X

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Hernandez Edgar
@Internistacl · X

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Prof.Fernando Parola
@Profeparola · X

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Julito Mateo
@JulitoMateo · X

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Lucas Monje
@MonjeLucax · X

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Mónica Lalanda
@mlalanda · X

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Dr. José Luis Neyro
@doctorneyro · X

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Alfonso Cedeno L.
@Alfcelo · X

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Luz María Córdova
@lusma1998 · X

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Luz Santos Diaz
@charm177 · X

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alssira larissa
@lari_katarinke · X

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Marrulita
@M4rrulita · X

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Dr.Rafael Díaz Sobac
@diazsobac · X

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♏
@MarceGuiani · X

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Jefferson Gutiérrez
@jeffeeeer7 · X

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Jacquelinnas_
@Jacquelinnas_ · X

RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…

Jul 5, 2023 · 44 shares · 385 followers View post →
Paul Sanchez
@palsanchz · X

RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…

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Dra. Angélica García
@lica2284 · X

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Roberto Bonilla
@bonillarob · X

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Dr. R
@DrR_medicina · X

RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…

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Burciaga
@Phikshu · X

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Nutrilauramejia
@nutrilauramejia · X

RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…

Jul 5, 2023 · 44 shares · 132 followers View post →
Ricardo Zúñiga Nutricionista - Dietista
@nutrideliveryec · X

RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…

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Tacos con Orejas
@TacosConOrejas · X

RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…

Jul 5, 2023 · 44 shares · 153 followers View post →
Ema.pf
@BlackStrongOk · X

RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…

Jul 5, 2023 · 44 shares · 52 followers View post →
luis alberto malaga
@malaga1711 · X

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Jul 5, 2023 · 44 shares · 1,601 followers View post →
Miguel Ibarra MD, MPH, PhD
@Miggs_Ibarra · X

RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…

Jul 5, 2023 · 44 shares · 629 followers View post →
R Giovanni Diaz-Zavala
@DrGiovanniD · X

RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…

Jul 5, 2023 · 44 shares · 16,001 followers View post →
Pablo Ortiz Navarro
@PabloGenis · X

RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…

Jul 5, 2023 · 44 shares · 849 followers View post →
Zyo
@zyo73 · X

RT @IberianCitizen: Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesg…

Jul 5, 2023 · 44 shares · 98 followers View post →
IberianCitizen
@IberianCitizen · X

Una restricción calórica del 25% ralentiza el envejecimiento en un 2-3% lo q correspondería a una reducción en el riesgo de mortalidad de un 10-15 %, similar al efecto de la intervención para dejar de fumar #ayuno #restriccion #aging #ADN #envejecimiento https://t.co/MrRMseLG3l https://t.co/zPkul4G2qP

Jul 5, 2023 · 143 likes · 44 shares · 12,931 followers View post →
DNAMethylationPapers
@DNAmPapers · X

Author Correction: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/8hxHYkyCUR https://t.co/alolQUtUUK

May 11, 2023 · 702 followers View post →
INSPIRE Platform - IHU HealthAge
@INSPIREPlatfor1 · X

"Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial." Nat Aging 3, 248–257 (2023). https://t.co/ukuBwl8qrd @brunovellas @isaperarnau @InfinityTLS @RestoreInstitut @I2mcT

Mar 27, 2023 · 674 followers View post →
Bruno Vellas
@brunovellas · X

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial | Nature Aging https://t.co/DKEH7g0Zp8

Mar 27, 2023 · 3 likes · 2,565 followers View post →
Ageing and Neurodegenerative Diseases
@OAE_AgeNeuDis · X

Mar 20, 2023 · 444 followers View post →
Carmen De Miguel, PhD, MS, FAHA
@Carmendemigue12 · X

RT @KidneyInCVD: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE…

Mar 16, 2023 · 1 share · 3,345 followers View post →
Kidney in Cardiovascular Disease
@KidneyInCVD · X

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial | Nature Aging https://t.co/otz4PVFft7

Mar 16, 2023 · 1 like · 1 share · 1,908 followers View post →
Daniel Belsky
@Danbelsky · X

@KarlPfleger @mike_lustgarten @olafurpall80 @bryan_johnson Clock ages at baseline are all over the place https://t.co/PwX1nQbawH

Feb 27, 2023 · 1 like · 1,773 followers View post →
Seiichi Mori
@seiichi_mori · X

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/39IwlBS1Lw https://t.co/lSdYlsDeM7

Feb 23, 2023 · 313 followers View post →
DrRPalmquist
@DrPalmquist · X

Letter Open Access Published: 09 February 2023 Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/Um03IgW1Sf

Feb 22, 2023 · 3,162 followers View post →
yared zegeye Geberetsadik
@yaredz · X

RT @nikmarino9: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE…

Feb 19, 2023 · 1 share · 318 followers View post →
Nicola Marino
@nikmarino9 · X

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/ZGju8CTB19

Feb 18, 2023 · 5 likes · 1 share · 8,753 followers View post →
Loquacità
@Loquacita · X

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/x0JR0lChlS via @Nature

Feb 17, 2023 · 437 followers View post →
Orlando_uy
@Orlando_uy · X

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. https://t.co/JwJJcoFFJr

Feb 16, 2023 · 689 followers View post →
George Dawson
@dawso007 · X

Open Access: Waziry, R., Ryan, C.P., Corcoran, D.L. et al. Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. Nat Aging (2023). https://t.co/jaIdc5ofuD

Feb 16, 2023 · 1 like · 7,818 followers View post →
浅野拓
@asanotaku_09 · X

■参考文献■ Nature Aging: 09 Feb, 2023 DOI: 10.1038/s43587-022-00357-y

Feb 15, 2023 · 7 likes · 13,028 followers View post →
Interesting Page Isn't It?
@glad_help · X

link: https://t.co/9cfgpcJcLx ⚕️

Feb 15, 2023 · 137 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/HXRA4VI4yk

Feb 15, 2023 · 2,241 followers View post →
Interesting Page Isn't It?
@glad_help · X

link: https://t.co/9cfgpcJcLx ⚕️

Feb 15, 2023 · 137 followers View post →
Norio Nakatsuji
@norionakatsuji · X

元論文→ Reference: Waziry R, Ryan CP, Corcoran DL, et al. Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. Nat. Aging. 2023. doi: 10.1038/s43587-022-00357-y. https://t.co/lhCMbU4BQJ

Feb 15, 2023 · 1 like · 15,707 followers View post →
Interesting Page Isn't It?
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Feb 14, 2023 · 137 followers View post →
Interesting Page Isn't It?
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Interesting Page Isn't It?
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Interesting Page Isn't It?
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Interesting Page Isn't It?
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Feb 14, 2023 · 137 followers View post →
docrodney
@docrodney · X

From @TIME IG post: ••• This new study demonstrates that calorie restriction may slow #aging in humans. Waziry, R., Ryan, C.P., Corcoran, D.L. et al. CALERIE trial. Nat Aging (2023). https://t.co/sUO6FAOXrv

Feb 13, 2023 · 1 like · 781 followers View post →
Divinity Seven♻️
@SevenDivinity · X

RT @JHUCIDNI: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE tr…

Feb 13, 2023 · 1 share · 1,363 followers View post →
Serine S.
@SerineS22 · X

RT @AgingBiology: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERI…

Feb 13, 2023 · 4 shares · 2 followers View post →
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@glad_help · X

link: https://t.co/9cfgpcJcLx ⚕️

Feb 13, 2023 · 137 followers View post →
Center for Infectious Disease & Nursing Innovation
@JHUCIDNI · X

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial | Nature Aging https://t.co/jEtvjYHGgF

Feb 13, 2023 · 1 like · 1 share · 1,688 followers View post →
Interesting Page Isn't It?
@glad_help · X

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Feb 13, 2023 · 137 followers View post →
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@glad_help · X

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Feb 13, 2023 · 137 followers View post →
CALERIE Study
@CalerieStudy · X

RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…

Feb 13, 2023 · 11 shares · 25 followers View post →
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@glad_help · X

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Feb 13, 2023 · 137 followers View post →
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さらす - PPMPPP
@t2saras · X

RT @sarekore: 老化速度を表す動的な指標において、カロリー制限は老化速度を2~3%遅らせることがわかりました。他の研究によれば、これは死亡リスクの10~15%の減少に相当し、禁煙と同様の効果です。ただし他の2つの静的な老化指標(生物年齢)では老化を遅らせる効果は認め…

Feb 13, 2023 · 1 share · 162 followers View post →
サイエンスあれこれ
@sarekore · X

老化速度を表す動的な指標において、カロリー制限は老化速度を2~3%遅らせることがわかりました。他の研究によれば、これは死亡リスクの10~15%の減少に相当し、禁煙と同様の効果です。ただし他の2つの静的な老化指標(生物年齢)では老化を遅らせる効果は認められませんでしたhttps://t.co/wSiXPnTWZd

Feb 13, 2023 · 1 share · 922 followers View post →
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@glad_help · X

link: https://t.co/9cfgpcJcLx ⚕️

Feb 12, 2023 · 137 followers View post →
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Feb 12, 2023 · 137 followers View post →
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@glad_help · X

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Transparent-Academia
@AgingDepth · X

RT @AgingBiology: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERI…

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Fay
@fay90028966 · X

RT @AgingBiology: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERI…

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Dr. Shashank Joshi
@AskDrShashank · X

RT @AgingBiology: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERI…

Feb 11, 2023 · 4 shares · 32,533 followers View post →
Aging Science News
@AgingBiology · X

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/bkXjO4JQp4

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Shahaf Peleg
@DocLarus · X

RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…

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Eve Beavers
@espacetimeCO · X

RT @nick_krontiris: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALE…

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Nick Krontiris
@nick_krontiris · X

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (open access) https://t.co/Lcjrmr9dpg #aging #longevity

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Ariakas Enoreth
@Aenoreth · X

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial https://t.co/f9b2JcIsO5

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Slawomir
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RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…

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Petar Angelov, CFA
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RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…

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April♥️
@HanBing2311 · X

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial | Nature Aging. https://t.co/ibLceIX4vp

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RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…

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Christopher Sylvain
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RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…

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RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…

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Daniel Belsky
@Danbelsky · X

RT @agingdoc1: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE t…

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Agingdoc
@agingdoc1 · X

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial R. Waziry, C. P. Ryan, @Danbelsky & coauthors https://t.co/3nRe7fk0fc @NatureAging https://t.co/90sxU7tP2U

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John Greene
@Greene_Thoughts · X

RT @agingdoc1: Great overview @Danbelsky @metabesity today. We would do well incentivizing optimal lifestyle practices via structure & poli…

Oct 12, 2021 · 1 share · 1,677 followers View post →
Agingdoc
@agingdoc1 · X

Great overview @Danbelsky @metabesity today. We would do well incentivizing optimal lifestyle practices via structure & policy initiatives

Oct 12, 2021 · 1 share · 41,233 followers View post →
AgingResearch
@TheAgingField · X

RT @agingdoc1: Effect of Long-Term Caloric Restriction on DNA Methylation Measures of Biological Aging in Healthy Adults: CALERIE™ Trial An…

Oct 9, 2021 · 1 share · 5,270 followers View post →
Agingdoc
@agingdoc1 · X

Effect of Long-Term Caloric Restriction on DNA Methylation Measures of Biological Aging in Healthy Adults: CALERIE™ Trial Analysis https://t.co/jrUUDZrUfC @biorxivpreprint “CALERIE intervention slowed Pace of Aging but showed minimal effect on epigenetic clocks..[GrimAge et]

Oct 9, 2021 · 13 likes · 1 share · 41,233 followers View post →
Alamsah
@alamsuhardi · X

RT @medrxivpreprint: Effect of Long-Term Caloric Restriction on DNA Methylation Measures of Biological Aging in Healthy Adults: CALERIETM T…

Sep 27, 2021 · 1 share · 12 followers View post →
medRxiv
@medrxivpreprint · X

Effect of Long-Term Caloric Restriction on DNA Methylation Measures of Biological Aging in Healthy Adults: CALERIETM Trial Analysis https://t.co/ML3cVZZ35s #medRxiv

Sep 26, 2021 · 3 likes · 1 share · 17,460 followers View post →