Transl Psychiatry May 2023 PMID 37147277

Methadone alters transcriptional programs associated with synapse formation in human cortical organoids.

Ila Dwivedi, Andrew B Caldwell, Dan Zhou, Wei Wu, Shankar Subramaniam, Gabriel G Haddad

Download social card

Mentions

Peak: 5 in Nov 2022

across 2 sources since Nov 2022

Extended reach

201,362

potential audience

Total likes

Video views

Mentions per month

Nov 2022 – Sep 2023

Where it's discussed

X / Twitter9 posts
YouTube1 videos

AI synopsis

What people are saying

Throughout the discussions, users frequently refer to the article as 'methadone alters transcriptional programs' and mention 'synapse formation,' highlighting key scientific concepts. The tone remains informative and neutral, with phrases like 'associated with' and 'potential effects,' which reflect acknowledgment rather than excitement or dismissal, aligning with moderate agreement and impact scores.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, with some posts either neutral or only mildly supportive, reflecting general agreement on its importance.

InterestModerate interest

Posts show moderate curiosity, with repeated mentions and references indicating some level of interest, but limited depth or enthusiastic commentary.

EngagementNeutral engagement

Many discussions mainly share links or shorthand remarks without in-depth analysis, suggesting a neutral level of engagement.

ImpactModerate impact

The majority seem to recognize the potential impact on understanding neurodevelopment and opioid effects, though expressed with cautious language.

Abstract in brief

The study shows that methadone, used to treat pregnant women with opioid use disorder, can impact early brain development by altering genes related to synapse formation, extracellular matrix, and cellular structures in human cortical organoids.
Researchers found that methadone influences a network of growth factors and signaling pathways, notably reducing levels of thrombospondin 1, which is important for synapse formation.
These findings suggest that prenatal methadone exposure might affect neurocognitive and behavioral development by disrupting molecular mechanisms critical for early brain development.]

Read the full abstract

All mentions

Impact of Methadone on Synapse Formation in Human Cortical Organoids

Methadone, used during pregnancy for opioid use disorder, can impact early brain development by altering genes related to synapse formation and cellular structures in human cortical organoids. This may influence…

Social RTCL TV · Sep 6, 2023 2 views

Synapse Articles

@ArticlesSynapse · X

Methadone alters transcriptional programs associated with synapse formation in human cortical organoids. https://t.co/BSF8aVwrQr

May 7, 2023 · 37 followers View post →

DTHSTR

@CDADeathStar · X

Methadone alters transcriptional programs associated with synapse formation in human null https://t.co/UojbYwFbDB #DTHSTR

May 6, 2023 · 113 followers View post →

Cilia Papers

@cilia_biblios · X

Methadone alters transcriptional programs associated with synapse formation in human cortical organoids https://t.co/81EwrvUApM https://t.co/oQfm9tuHM4

May 6, 2023 · 2 likes · 1,165 followers View post →

Andrew Caldwell

@AndrewBCaldwell · X

RT @biorxivpreprint: Methadone alters transcriptional programs associated with synapse formation in human cortical organoids https://t.co/…

Feb 9, 2023 · 1 share · 673 followers View post →

iBraiN Inserm Lab

@iBrain_Inserm · X

RT @biorxiv_neursci: Methadone alters transcriptional programs associated with synapse formation in human cortical organoids https://t.co/…

Nov 5, 2022 · 2 shares · 1,722 followers View post →

Unreadable Preprint Bot

@UnReadBot · X

Methadone alters transcriptional programs associated with synapse formation in human cortical organoids FK grade 20 (very unreadable)

Nov 5, 2022 · 16 followers View post →

Nonso Nduka

@NonsoNduka3 · X

RT @biorxiv_neursci: Methadone alters transcriptional programs associated with synapse formation in human cortical organoids https://t.co/…

Nov 5, 2022 · 2 shares · 211 followers View post →

bioRxiv Neuroscience

@biorxiv_neursci · X

Methadone alters transcriptional programs associated with synapse formation in human cortical organoids https://t.co/koxwQ2HzFH #biorxiv_neursci

Nov 5, 2022 · 4 likes · 2 shares · 60,053 followers View post →

bioRxiv

@biorxivpreprint · X

Methadone alters transcriptional programs associated with synapse formation in human cortical organoids https://t.co/GDRS1wg3lH #bioRxiv

Nov 5, 2022 · 1 like · 1 share · 137,355 followers View post →