Nat Commun May 2023 PMID 37160898

Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1.

Juan Pang, Fitore Raka, Alya Abbas Heirali, Weijuan Shao, Dinghui Liu, Jianqiu Gu, Jia Nuo Feng, Chieko Mineo, Philip W Shaul, Xiaoxian Qian, Bryan Coburn, Khosrow Adeli, Wenhua Ling, Tianru Jin

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Peak: 2 in May 2023

across 4 sources since May 2023

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May 2023 – Aug 2023

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What people are saying

Throughout the discussions, users reference the article's focus on gut microbiota and lipid metabolism, with phrases like 'shows how resveratrol reduces chylomicron secretion,' and 'potential for new dietary interventions.' The tone combines scientific curiosity and optimism, emphasizing mechanisms and future implications, which reflects a generally positive and engaged response to the publication.

AgreementModerate agreement

Many discussions seem to agree with the findings, viewing the results as promising or consistent with existing knowledge about resveratrol's effects.

InterestModerate interest

The discussions show moderate curiosity, with some comments highlighting potential applications and mechanisms, indicating genuine interest.

EngagementModerate engagement

Participants delve into specific details of the study, referencing gut microbiota and molecular pathways, demonstrating active engagement.

ImpactModerate impact

The posts suggest that the study could influence future research and dietary considerations, indicating a perceived moderate to high impact.

Abstract in brief

Resveratrol intervention (REVI) reduces chylomicron secretion in mice on a high-fat diet by decreasing the expression of the intestinal receptor SRB1, without affecting the liver.
The beneficial effects of REVI are primarily mediated through changes in gut microbiota, which influence bile acid levels and FXR activity, rather than direct action on intestinal cells.
Fecal microbiota transplantation from REVI-treated mice can replicate some effects, highlighting the gut microbiome's crucial role in mediating resveratrol's impact on lipid metabolism.

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All mentions

Resveratrol Reduces Chylomicron Secretion by Targeting Gut Receptors

Resveratrol intervention reduces chylomicron secretion by decreasing intestinal SRB1 expression, primarily through gut microbiota changes that affect bile acids and FXR activity, without impacting the liver.

STEM RTCL TV · Aug 19, 2023 18 views

Department of Laboratory Medicine & Pathobiology

@UofT_LMP · X

Jun 7, 2023 · 2 likes · 1 share · 1,120 followers View post →

Jon Rocheleau

@Rocheleau_QM3 · X

Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of… https://t.co/FGzrDZT0BK

May 10, 2023 · 398 followers View post →

micropapers

@micro_papers · X

Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1 https://t.co/pO0JqSVfuw

May 10, 2023 · 332 followers View post →