Effects of hunger on neuronal histone modifications slow aging in .

K J Weaver, R A Holt, E Henry, Y Lyu, S D Pletcher

May 2023 Science

Synopsis of Social media discussions

The discussions consistently highlight the groundbreaking nature of the findings, with posts describing how activating hunger-promoting neurons can extend lifespan even with increased food intake. The tone is enthusiastic, referencing authoritative sources like Science Magazine and emphasizing the potential to reshape aging research by focusing on motivational states like hunger, which adds depth by exploring biological mechanisms and real-world implications.

A
Agreement
 Strong agreement

Most discussions praise the research, emphasizing its significance and exciting implications for aging and longevity.

I
Interest
 High level of interest

Posts demonstrate high interest, sharing multiple links, quotes, and reactions highlighting the novelty of hunger's role in lifespan extension.

E
Engagement
 High engagement

Many discussions reference specific findings, authors, and biological mechanisms, indicating deep engagement with the scientific content.

I
Impact
 High level of impact

The widespread enthusiasm and emphasis on potential applications show that the research is perceived as having a high impact on understanding aging and influencing future studies.

Social Mentions

YouTube

2 Videos

Facebook

9 Posts

Twitter

108 Posts

Instagram

1 Posts

Blogs

1 Articles

News

23 Articles

Metrics

Video Views

8,096

Total Likes

493

Extended Reach

1,010,175

Social Features

144

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Hunger and Neuronal Modifications Influence Aging and Longevity

Hunger and Neuronal Modifications Influence Aging and Longevity

Hunger influences aging through changes in neuronal histone modifications, involving BCAA limitation and activation of hunger-promoting neurons. These alterations are key to lifespan extension, highlighting the role of motivational states like hunger in aging processes.

美聽

November 12, 2025

7,905 views

Hunger's Role in Extending Lifespan Through Neuronal Changes

Hunger's Role in Extending Lifespan Through Neuronal Changes

Unlock secrets of longevity as researchers explore how hunger influences aging by modifying neuronal histone acetylation, particularly involving BCAA levels, and activating hunger-promoting neurons to extend lifespan.

Zootro Life Longevity

March 11, 2024

191 views

  • 이준
    @x20081266 (Twitter)

    飢餓可以延緩衰老 https://t.co/im45WobbU8
    view full post

    April 25, 2025

  • Surojit Sural
    @surojitsural (Twitter)

    RT @joshuagruber: Trying to live longer but don’t want to starve yourself? Try this fly diet. In a truly remarkable set of findings the a…
    view full post

    July 22, 2024

    1

  • Joshua J. Gruber
    @joshuagruber (Twitter)

    Trying to live longer but don’t want to starve yourself? Try this fly diet. In a truly remarkable set of findings the authors show that giving flies less branched chain amino acids makes them hungry so they eat more — but still end up living longer. https://t.co/lt0WDGnAC4
    view full post

    July 22, 2024

    14

    1

  • ボサノバ父さん
    @yakkairojin (Twitter)

    RT @sarekore: 空腹感そのものが老化を遅らせる原動力である可能性を示唆しています。Science誌https://t.co/3dhq3HFJWY
    view full post

    July 15, 2024

    1

  • Chase W. Nelson 倪誠志
    @chasewnelson (Twitter)

    Hunger alone — even without caloric restriction — is sufficient to extend life span in flies. Does living longer really come down to motivational states? | Weaver et al. @ScienceMagazine https://t.co/vWqx45rIci
    view full post

    December 27, 2023

    1

  • JK Nandakumar lab
    @LabNandakumar (Twitter)

    RT @MicheleLabUM: Congrats to @UMPhysiology faculty Dr. Scott Pletcher for recieving the 2023 @umichmedicine Basic Science Research Award f…
    view full post

    October 17, 2023

    4

  • Lyssiotis Lab
    @LyssiotisLab (Twitter)

    RT @MicheleLabUM: Congrats to @UMPhysiology faculty Dr. Scott Pletcher for recieving the 2023 @umichmedicine Basic Science Research Award f…
    view full post

    October 17, 2023

    4

  • Tuhin S Chakraborty
    @TuhinSChakrabo1 (Twitter)

    RT @MicheleLabUM: Congrats to @UMPhysiology faculty Dr. Scott Pletcher for recieving the 2023 @umichmedicine Basic Science Research Award f…
    view full post

    October 17, 2023

    4

  • UMPhysiology
    @UMPhysiology (Twitter)

    RT @MicheleLabUM: Congrats to @UMPhysiology faculty Dr. Scott Pletcher for recieving the 2023 @umichmedicine Basic Science Research Award f…
    view full post

    October 17, 2023

    4

  • Dan Michele
    @MicheleLabUM (Twitter)

    Congrats to @UMPhysiology faculty Dr. Scott Pletcher for recieving the 2023 @umichmedicine Basic Science Research Award for his research on interactions of sensory perception, diet, and aging. Some of his lab's recent work here: https://t.co/dbkFb0xEIH https://t.co/kQVkQH6sRQ https://t.co/FvXfrNYzRl
    view full post

    October 17, 2023

    13

    4

  • medicalnews
    @medicalnews20 (Twitter)

    https://t.co/pgeCEqzl6x ​Science: Feeling Hungry is enough to delay aging. Researchers from the University of Michigan published a research paper entitled: Effects of hunger on neuronal histone modifications slow aging in Drosophila in the journal Science.... #aging #Diet
    view full post

    August 1, 2023

  • Helen Martirosova,PhD, MSc
    @HMartirosova (Twitter)

    https://t.co/VbcIybctRq
    view full post

    July 20, 2023

  • igdhk
    @5yymfH (Twitter)

    空腹はがショウジョウバエの寿命を調整する。 分岐鎖アミノ酸BCAAの制限もしくは空腹刺激ニューロンの活性化は空腹感をもたらし食事量をふやしても寿命を伸ばした。 https://t.co/f7iFprKaks
    view full post

    July 20, 2023

    1

  • Peter Adams
    @AdamsBioAging (Twitter)

    This is so cool! Here’s the link for those who can’t get from @agingdoc1 post https://t.co/QcLCDGPtwJ. https://t.co/KN8BGkSpkp
    view full post

    June 16, 2023

    8

  • おくさん/OKUSUN
    @Astella6174 (Twitter)

    ・空腹感を引き起こすニューロンを直接活性化させたハエは長生きした。 ・また、ハエの食事に含まれるBCAAの低下は空腹ニューロンによるヒストン修飾に変化をもたらす可能性が示唆されててなかなかおもろい（これまでもヒストンが寿命と関わる可能性を示唆する報告がある） https://t.co/N53Vb56Q82
    view full post

    June 8, 2023

  • やまだ@腸活×アンチエイジング
    @tarou_ymd_ (Twitter)

    ヒストンというのは長いDNAを核内に折り畳んで入れる時に必要なタンパク質です。そして、ヒストンというのはDNAのスイッチのON-OFFに関わっています。ここにアセチル化という修飾が起きると遺伝子のスイッチがONになるわけです。 #山田の論文365 　その138 https://t.co/mHwOpjsJNF
    view full post

    June 6, 2023

    2

  • No Horizons
    @1stmousecheese (Twitter)

    RT @agingdoc1: Effects of hunger on neuronal histone modifications slow aging in Drosophila @ScienceMagazine https://t.co/TiOVzV4Mng htt…
    view full post

    June 5, 2023

    1

  • Agingdoc
    @agingdoc1 (Twitter)

    Effects of hunger on neuronal histone modifications slow aging in Drosophila @ScienceMagazine https://t.co/TiOVzV4Mng https://t.co/REdZWasNj8
    view full post

    June 5, 2023

    11

    1

  • サイエンスあれこれ
    @sarekore (Twitter)

    空腹感そのものが老化を遅らせる原動力である可能性を示唆しています。Science誌https://t.co/3dhq3HFJWY
    view full post

    June 4, 2023

    6

    1

  • claimshero.eth
    @claimshero__eth (Twitter)

    RT @EstebanDL: Pasar hambre le extendió la vida a la mosca de la fruta https://t.co/RCH7A4zK0a https://t.co/kBvxzYQRuh
    view full post

    June 1, 2023

    5

  • ...
    @perisincardio (Twitter)

    RT @EstebanDL: Pasar hambre le extendió la vida a la mosca de la fruta https://t.co/RCH7A4zK0a https://t.co/kBvxzYQRuh
    view full post

    May 31, 2023

    5

  • Dra. Teresa Pascual
    @DraTPascual (Twitter)

    RT @EstebanDL: Pasar hambre le extendió la vida a la mosca de la fruta https://t.co/RCH7A4zK0a https://t.co/kBvxzYQRuh
    view full post

    May 31, 2023

    5

  • leonidas
    @leonidacass (Twitter)

    RT @EstebanDL: Pasar hambre le extendió la vida a la mosca de la fruta https://t.co/RCH7A4zK0a https://t.co/kBvxzYQRuh
    view full post

    May 31, 2023

    5

  • Carlos
    @de_montecristo (Twitter)

    RT @EstebanDL: Pasar hambre le extendió la vida a la mosca de la fruta https://t.co/RCH7A4zK0a https://t.co/kBvxzYQRuh
    view full post

    May 31, 2023

    5

  • Larronde Esteban
    @EstebanDL (Twitter)

    Pasar hambre le extendió la vida a la mosca de la fruta https://t.co/RCH7A4zK0a https://t.co/kBvxzYQRuh
    view full post

    May 31, 2023

    21

    5

  • Qivshi
    @Qivshi1 (Twitter)

    Does it really do this? Reminds me of this study that showed merely stimulating hunger associated in fly brains they were able to extend lifespans https://t.co/1XxDhmWP23 https://t.co/uLyssRZdNP
    view full post

    May 23, 2023

  • Mr X - X 先生 话题论坛
    @635abec646414f2 (Twitter)

    延长人体寿命的重大发现： 最新研究得出结论： 是饥饿感本身，而非摄食行为或食物能量特性，减缓了衰老的发生 找到了以往研究文章中发现“八分饱”摄食量与“延年益寿”之间的关联的具体原因， 发表在Science，“Effects of hunger on neuronal histone modifications slow aging in Drosophila” https://t.co/bYRGcJ3wV3
    view full post

    May 20, 2023

  • Jingfeng Xiao
    @GlobalEcolUNH (Twitter)

    Effects of hunger on neuronal histone modifications slow aging in Drosophila https://t.co/QgszsqBAQ3
    view full post

    May 20, 2023

    1

  • Creative Bioarray
    @CreaBioarray (Twitter)

    Effects of hunger on neuronal histone modifications slow aging in Drosophila https://t.co/EzizsYEtO1
    view full post

    May 20, 2023

  • ﾉﾑ
    @nomu__2525 (Twitter)

    RT @Bio_stations: 空腹感が寿命を延ばす 食欲にかかわる神経を強制的に活性化するだけで寿命が延びたりするらしい(ハエの系)。脳でのヒストンアセチル化の変化がこの制御にかかわるとか。 摂食量が減らなくてもいいのか、？驚き https://t.co/N1EN8w…
    view full post

    May 19, 2023

    28

  • Anirban Kundu (Ph.D.)
    @Lab_AKundu (Twitter)

    RT @LocasaleLab: Interesting paper showing limiting branched chain amino acids in diet extends lifespan in flies and neuronal mechanisms ma…
    view full post

    May 18, 2023

    2

  • 下浦雄大(ゆうた)｜いびきのお医者さん
    @yukichi_ibiki (Twitter)

    RT @seek_science: 空腹は老化を遅らせる。ミシガン大学の研究で、エサの制限や遺伝子操作により空腹を引き起こすと、エサの量に関係なく寿命が延びることを確認。さらに、長引く空腹は、空腹を感じるハードルを下げることも確認。やっぱり断食は体にいいみたい。たまに朝を抜くの…
    view full post

    May 18, 2023

    1

  • Maple the Maine Coon
    @ergonod (Twitter)

    RT @LocasaleLab: Interesting paper showing limiting branched chain amino acids in diet extends lifespan in flies and neuronal mechanisms ma…
    view full post

    May 18, 2023

    2

  • Jason Locasale
    @LocasaleLab (Twitter)

    Interesting paper showing limiting branched chain amino acids in diet extends lifespan in flies and neuronal mechanisms may be involved. https://t.co/3FqeR7GwdY
    view full post

    May 18, 2023

    15

    2

  • MUSC Microbiology and Immunology (M&I)
    @MUSC_MI (Twitter)

    RT @enhancerleo: STAY HUNGRY!!! Activating #hunger promoting #neurons extends #lifespan in fruit flies even if feeding itself is increased!…
    view full post

    May 18, 2023

    3

  • Lyssiotis Lab
    @LyssiotisLab (Twitter)

    RT @UMichMedScience: New research from Scott Pletcher, Kristy Weaver (@KristyJo33 ) et al. in @ScienceMagazine finds hunger alone can incr…
    view full post

    May 18, 2023

    5

  • しーく|小さな習慣のコンシェルジュ
    @seek_science (Twitter)

    空腹は老化を遅らせる。ミシガン大学の研究で、エサの制限や遺伝子操作により空腹を引き起こすと、エサの量に関係なく寿命が延びることを確認。さらに、長引く空腹は、空腹を感じるハードルを下げることも確認。やっぱり断食は体にいいみたい。たまに朝を抜くのもありかも。 https://t.co/By0gZlmtDQ
    view full post

    May 18, 2023

    7

    1

  • Yang Lyu
    @Yang_Lyu (Twitter)

    Best art in my scientific career, but it can barely show how cool the new discoveries made by @kristyjo33 really are: https://t.co/WuvwUtIX4j https://t.co/kJd7STpVqL
    view full post

    May 18, 2023

    6

  • Kurt Prins
    @kurt_prins (Twitter)

    RT @UMichMedScience: New research from Scott Pletcher, Kristy Weaver (@KristyJo33 ) et al. in @ScienceMagazine finds hunger alone can incr…
    view full post

    May 18, 2023

    5

  • Kristy Jo Weaver
    @KristyJo33 (Twitter)

    RT @UMichMedScience: New research from Scott Pletcher, Kristy Weaver (@KristyJo33 ) et al. in @ScienceMagazine finds hunger alone can incr…
    view full post

    May 18, 2023

    5

  • Monica Wolf Cadilhe
    @MonicaWolfC (Twitter)

    “motivational states alone can be deterministic drivers of aging” https://t.co/wCicuKl4ol
    view full post

    May 18, 2023

  • Debbie @ Genetic Lifehacks
    @GeneticLifehack (Twitter)

    Increased hunger through specific amino acid restriction increased lifespan, even with more food consumption Effects of hunger on neuronal histone modifications slow aging in Drosophila | Science https://t.co/p1blmUPyPb
    view full post

    May 18, 2023

    2

  • Dan Michele
    @MicheleLabUM (Twitter)

    RT @UMichMedScience: New research from Scott Pletcher, Kristy Weaver (@KristyJo33 ) et al. in @ScienceMagazine finds hunger alone can incr…
    view full post

    May 18, 2023

    5

  • U-M Medical School Research
    @UMichMedScience (Twitter)

    New research from Scott Pletcher, Kristy Weaver (@KristyJo33 ) et al. in @ScienceMagazine finds hunger alone can increase life span in fruit flies https://t.co/4kK90cmAhn
    view full post

    May 18, 2023

    14

    5

  • Genç İVEK
    @gencivek (Twitter)

    ‘’Bilimde Bu Hafta" köşemiz 11.05.2023 - 18.05.2023
    view full post

    May 18, 2023

    3

  • ぷりんちゃん
    @shiroku66240615 (Twitter)

    RT @Bio_stations: 空腹感が寿命を延ばす 食欲にかかわる神経を強制的に活性化するだけで寿命が延びたりするらしい(ハエの系)。脳でのヒストンアセチル化の変化がこの制御にかかわるとか。 摂食量が減らなくてもいいのか、？驚き https://t.co/N1EN8w…
    view full post

    May 18, 2023

    28

  • Dr. Sudip Das
    @sudu87 (Twitter)

    RT @enhancerleo: STAY HUNGRY!!! Activating #hunger promoting #neurons extends #lifespan in fruit flies even if feeding itself is increased!…
    view full post

    May 18, 2023

    3

  • Zafar Ali
    @ZafarAl58819632 (Twitter)

    RT @NutrioSci: motivational states alone can be deterministic drivers of aging @ScienceMagazine #science #aging #Hunger #research #Biology…
    view full post

    May 18, 2023

    3

  • Matias Hartman
    @HartmanMatias_ (Twitter)

    RT @enhancerleo: STAY HUNGRY!!! Activating #hunger promoting #neurons extends #lifespan in fruit flies even if feeding itself is increased!…
    view full post

    May 17, 2023

    3

  • Leonardo Ferreira
    @enhancerleo (Twitter)

    STAY HUNGRY!!! Activating #hunger promoting #neurons extends #lifespan in fruit flies even if feeding itself is increased! Feeling hungry is enough to slow down aging! #mindpower #slowaging @UMichiganNews @ScienceMagazine https://t.co/9mcKHH1ca8 https://t.co/kgdzWLRdVi
    view full post

    May 17, 2023

    14

    3

  • Timi Jay
    @3d_idan (Twitter)

    RT @NutrioSci: motivational states alone can be deterministic drivers of aging @ScienceMagazine #science #aging #Hunger #research #Biology…
    view full post

    May 17, 2023

    3

  • 花染そまり@Vtuber/Hanazome Somary
    @Somarie_Vtuber (Twitter)

    RT @Bio_stations: 空腹感が寿命を延ばす 食欲にかかわる神経を強制的に活性化するだけで寿命が延びたりするらしい(ハエの系)。脳でのヒストンアセチル化の変化がこの制御にかかわるとか。 摂食量が減らなくてもいいのか、？驚き https://t.co/N1EN8w…
    view full post

    May 17, 2023

    28

  • yu
    @nonneko_sinkai (Twitter)

    RT @Bio_stations: 空腹感が寿命を延ばす 食欲にかかわる神経を強制的に活性化するだけで寿命が延びたりするらしい(ハエの系)。脳でのヒストンアセチル化の変化がこの制御にかかわるとか。 摂食量が減らなくてもいいのか、？驚き https://t.co/N1EN8w…
    view full post

    May 17, 2023

    28

  • 沼Utsubo@Kummerspeck
    @epsilonminder (Twitter)

    RT @Bio_stations: 空腹感が寿命を延ばす 食欲にかかわる神経を強制的に活性化するだけで寿命が延びたりするらしい(ハエの系)。脳でのヒストンアセチル化の変化がこの制御にかかわるとか。 摂食量が減らなくてもいいのか、？驚き https://t.co/N1EN8w…
    view full post

    May 16, 2023

    28

  • Raymond
    @raymzyu (Twitter)

    RT @Bio_stations: 空腹感が寿命を延ばす 食欲にかかわる神経を強制的に活性化するだけで寿命が延びたりするらしい(ハエの系)。脳でのヒストンアセチル化の変化がこの制御にかかわるとか。 摂食量が減らなくてもいいのか、？驚き https://t.co/N1EN8w…
    view full post

    May 16, 2023

    28

  • もとやまめぐ
    @Mossan_Kei (Twitter)

    RT @Bio_stations: 空腹感が寿命を延ばす 食欲にかかわる神経を強制的に活性化するだけで寿命が延びたりするらしい(ハエの系)。脳でのヒストンアセチル化の変化がこの制御にかかわるとか。 摂食量が減らなくてもいいのか、？驚き https://t.co/N1EN8w…
    view full post

    May 16, 2023

    28

  • ポメチャン
    @SK_20200123 (Twitter)

    RT @Bio_stations: 空腹感が寿命を延ばす 食欲にかかわる神経を強制的に活性化するだけで寿命が延びたりするらしい(ハエの系)。脳でのヒストンアセチル化の変化がこの制御にかかわるとか。 摂食量が減らなくてもいいのか、？驚き https://t.co/N1EN8w…
    view full post

    May 16, 2023

    28

  • muffmuff
    @muffmuff5 (Twitter)

    RT @Bio_stations: 空腹感が寿命を延ばす 食欲にかかわる神経を強制的に活性化するだけで寿命が延びたりするらしい(ハエの系)。脳でのヒストンアセチル化の変化がこの制御にかかわるとか。 摂食量が減らなくてもいいのか、？驚き https://t.co/N1EN8w…
    view full post

    May 16, 2023

    28

  • 京滋池戸会
    @ikenobekai (Twitter)

    RT @Bio_stations: 空腹感が寿命を延ばす 食欲にかかわる神経を強制的に活性化するだけで寿命が延びたりするらしい(ハエの系)。脳でのヒストンアセチル化の変化がこの制御にかかわるとか。 摂食量が減らなくてもいいのか、？驚き https://t.co/N1EN8w…
    view full post

    May 16, 2023

    28

  • Shah Lab
    @YatrikShahLab (Twitter)

    RT @MicheleLabUM: Congrats to recently graduated @UMPhysiology PhD student Dr. @KristyJo33 and the Pletcher lab for her paper in @ScienceM…
    view full post

    May 16, 2023

    8

  • Dan (田上英明)
    @gatnad1 (Twitter)

    RT @Bio_stations: 空腹感が寿命を延ばす 食欲にかかわる神経を強制的に活性化するだけで寿命が延びたりするらしい(ハエの系)。脳でのヒストンアセチル化の変化がこの制御にかかわるとか。 摂食量が減らなくてもいいのか、？驚き https://t.co/N1EN8w…
    view full post

    May 16, 2023

    28

  • Dr Imran Sheikh
    @DrImranSheikh (Twitter)

    Effects of hunger on neuronal histone modifications slow aging in Drosophila https://t.co/glBGqUBzJm https://t.co/VpdvwFLO7G
    view full post

    May 16, 2023

  • Kamejiro
    @10000Years_Kame (Twitter)

    RT @Bio_stations: 空腹感が寿命を延ばす 食欲にかかわる神経を強制的に活性化するだけで寿命が延びたりするらしい(ハエの系)。脳でのヒストンアセチル化の変化がこの制御にかかわるとか。 摂食量が減らなくてもいいのか、？驚き https://t.co/N1EN8w…
    view full post

    May 16, 2023

    28

  • 高穂｜永福町
    @shimokunetaka (Twitter)

    RT @Bio_stations: 空腹感が寿命を延ばす 食欲にかかわる神経を強制的に活性化するだけで寿命が延びたりするらしい(ハエの系)。脳でのヒストンアセチル化の変化がこの制御にかかわるとか。 摂食量が減らなくてもいいのか、？驚き https://t.co/N1EN8w…
    view full post

    May 16, 2023

    28

  • baramonia
    @baramonia (Twitter)

    RT @Bio_stations: 空腹感が寿命を延ばす 食欲にかかわる神経を強制的に活性化するだけで寿命が延びたりするらしい(ハエの系)。脳でのヒストンアセチル化の変化がこの制御にかかわるとか。 摂食量が減らなくてもいいのか、？驚き https://t.co/N1EN8w…
    view full post

    May 16, 2023

    28

  • Leiy
    @leur123 (Twitter)

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    RT @Bio_stations: 空腹感が寿命を延ばす 食欲にかかわる神経を強制的に活性化するだけで寿命が延びたりするらしい(ハエの系)。脳でのヒストンアセチル化の変化がこの制御にかかわるとか。 摂食量が減らなくてもいいのか、？驚き https://t.co/N1EN8w…
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    May 16, 2023

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    @Bio_stations (Twitter)

    空腹感が寿命を延ばす 食欲にかかわる神経を強制的に活性化するだけで寿命が延びたりするらしい(ハエの系)。脳でのヒストンアセチル化の変化がこの制御にかかわるとか。 摂食量が減らなくてもいいのか、？驚き https://t.co/N1EN8wAuxR
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    @imedverse (Twitter)

    RT @NutrioSci: motivational states alone can be deterministic drivers of aging @ScienceMagazine #science #aging #Hunger #research #Biology…
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    RT @TuhinSChakrabo1: Check out the Latest paper from Pletcher Lab: https://t.co/YhoKOgU11B Congrats to @KristyJo33 and all co-authors.
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    मिशिगन युनिभर्सिटीको अध्ययन अनुसार भोकको अनुभूतिले बुढ्यौली ढिला हुन योगदान पुर्‍याउन सक्छ। https://t.co/X6gWRDzJB1
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    Effects of hunger on neuronal histone modifications slow aging in Drosophila https://t.co/YqY6JER6gA https://t.co/iTplC15eaj
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    RT @TuhinSChakrabo1: Check out the Latest paper from Pletcher Lab: https://t.co/YhoKOgU11B Congrats to @KristyJo33 and all co-authors.
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    RT @MicheleLabUM: Congrats to recently graduated @UMPhysiology PhD student Dr. @KristyJo33 and the Pletcher lab for her paper in @ScienceM…
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    RT @TuhinSChakrabo1: Check out the Latest paper from Pletcher Lab: https://t.co/YhoKOgU11B Congrats to @KristyJo33 and all co-authors.
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    Effects of hunger on neuronal histone modifications slow aging in Drosophila https://t.co/uITXdWGgd4
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    Effects of hunger on neuronal histone modifications slow aging in Drosophila https://t.co/CoQLhM2yyn
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    Wishing to live long? Don't eat. https://t.co/6hK45Pikqo
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    RT @MicheleLabUM: Congrats to recently graduated @UMPhysiology PhD student Dr. @KristyJo33 and the Pletcher lab for her paper in @ScienceM…
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  • Jiajia Chen, PhD, PMP
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    RT @AgingBiology: Effects of hunger on neuronal histone modifications slow aging in Drosophila https://t.co/cYJh2tW1tN
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    May 12, 2023

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  • Harmit S. Malik
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    Science Magazine - Effects of hunger on neuronal histone modifications slow aging in <i>Drosophila</i> https://t.co/t5UHygRDzZ
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    May 12, 2023

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  • Patrick Hu
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    RT @TuhinSChakrabo1: Check out the Latest paper from Pletcher Lab: https://t.co/YhoKOgU11B Congrats to @KristyJo33 and all co-authors.
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    Fascinating! https://t.co/PooM62DSyl
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    May 11, 2023

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    @HYtane (Twitter)

    RT @CircadianClocks: Interesting! Effects of hunger on neuronal histone modifications slow aging in Drosophila https://t.co/LRWXowXmk9
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  • Surojit Sural
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    RT @MicheleLabUM: Congrats to recently graduated @UMPhysiology PhD student Dr. @KristyJo33 and the Pletcher lab for her paper in @ScienceM…
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  • Olivia Zhou
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    RT @ShorterLab: Effects of hunger on neuronal histone modifications slow aging in Drosophila: https://t.co/FlZSHxT28W
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    May 11, 2023

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  • biotech archives
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    RT @AgingBiology: Effects of hunger on neuronal histone modifications slow aging in Drosophila https://t.co/cYJh2tW1tN
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  • Geoffroy Mallaret
    @MallaretG (Twitter)

    RT @CircadianClocks: Interesting! Effects of hunger on neuronal histone modifications slow aging in Drosophila https://t.co/LRWXowXmk9
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    May 11, 2023

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  • Joseph Takahashi
    @CircadianClocks (Twitter)

    Interesting! Effects of hunger on neuronal histone modifications slow aging in Drosophila https://t.co/LRWXowXmk9
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    May 11, 2023

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  • Sadagurski lab
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    RT @MicheleLabUM: Congrats to recently graduated @UMPhysiology PhD student Dr. @KristyJo33 and the Pletcher lab for her paper in @ScienceM…
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  • Neuroscience News
    @NeuroscienceNew (Twitter)

    “Effects of hunger on neuronal histone modifications slow aging in Drosophila” by Kristy Weaver et al. Science https://t.co/dDkOwEsBHQ
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    May 11, 2023

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  • Aging Science News
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    Effects of hunger on neuronal histone modifications slow aging in Drosophila https://t.co/cYJh2tW1tN
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    May 11, 2023

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  • M.Safa Karagoez
    @mskaragoez (Twitter)

    RT @ShorterLab: Effects of hunger on neuronal histone modifications slow aging in Drosophila: https://t.co/FlZSHxT28W
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    May 11, 2023

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  • Lyssiotis Lab
    @LyssiotisLab (Twitter)

    RT @MicheleLabUM: Congrats to recently graduated @UMPhysiology PhD student Dr. @KristyJo33 and the Pletcher lab for her paper in @ScienceM…
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    May 11, 2023

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  • ShorterLab
    @ShorterLab (Twitter)

    Effects of hunger on neuronal histone modifications slow aging in Drosophila: https://t.co/FlZSHxT28W
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    May 11, 2023

    8

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Abstract Synopsis

  • Hunger influences aging through changes in neuronal histone modifications, specifically involving BCAA limitation and activation of hunger-promoting neurons, which can extend lifespan even with increased feeding.
  • The study highlights that alterations in the neuronal histone acetylome, especially related to BCAA levels, are key to this process, and preventing these changes stops the lifespan extension.
  • Additionally, the research shows that hunger itself, whether short-term or prolonged, can regulate feeding behavior and aging, suggesting that motivational states like hunger are powerful factors in determining how we age.]