Nat Commun May 2023 PMID 37173324

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response.

Meghana Pagadala, Timothy J Sears, Victoria H Wu, Eva Pérez-Guijarro, Hyo Kim, Andrea Castro, James V Talwar, Cristian Gonzalez-Colin, Steven Cao, Benjamin J Schmiedel, Shervin Goudarzi, Divya Kirani, Jessica Au, Tongwu Zhang, Teresa Landi

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Mentions

Peak: 4 in May 2023

across 3 sources since May 2023

Extended reach

1,218

potential audience

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May 2023 – Aug 2023

Where it's discussed

News16 articles
X / Twitter4 posts
YouTube1 videos

AI synopsis

What people are saying

The discussions largely recognize the importance of the genetic factors in shaping tumor environments and therapy responses, with phrases like 'potential game-changer' hinting at high impact. The tone varies from neutral to optimistic, with some users highlighting the novel approach of targeting CTSS to slow tumor growth, demonstrating both interest and engagement.

AgreementModerate agreement

Most discussions acknowledge the significance of the research in linking germline variations to cancer risk and therapy response.

InterestNeutral interest

Comments show moderate curiosity, with some posters simply noting the topic without deep analysis.

EngagementModerate engagement

Several users reference specific aspects like the role of polygenic scores and the gene CTSS, indicating a moderate level of engagement.

ImpactModerate impact

There is a shared perception that this research could potentially influence future cancer treatments, but few discuss immediate clinical applications.

Abstract in brief

The study identifies specific genetic variants (eQTLs) that influence the tumor immune microenvironment (TIME), which are linked to cancer risk and how patients respond to immunotherapy.
Researchers developed polygenic scores based on these eQTLs that can predict cancer risk, survival outcomes, and response to immune checkpoint blockade across different patient groups.
By inhibiting the gene CTSS, identified through these genetic analyses, the researchers demonstrated slowed tumor growth and improved survival in vivo, highlighting a potential new target for cancer immunotherapy.]

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All mentions

Genetic Factors Influencing Tumor Immune Microenvironment and Cancer Risk

This study identifies genetic variants influencing the tumor immune microenvironment, impacting cancer risk and immunotherapy response. It highlights potential targets like CTSS for novel cancer treatments.

STEM RTCL TV · Aug 27, 2023 36 views

minnlab_litbot

@MLitbot · X

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response https://t.co/yBr1yfMhIu https://t.co/2lBSbs0oD3

May 13, 2023 · 72 followers View post →

PRS papers

@PRS_pubmed · X

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response https://t.co/LxGGWP3XDZ

May 13, 2023 · 398 followers View post →

Dendritic Cell Papers

@DenCell_Papers · X

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response https://t.co/OecK0HlvEd

May 13, 2023 · 86 followers View post →

eQTLpapers

@eQTL_papers · X

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response https://t.co/QBxJKa1Ywz https://t.co/VVhDeJvIpd

May 13, 2023 · 626 followers View post →