Nat Neurosci June 2023 PMID 37217725

First-in-human prediction of chronic pain state using intracranial neural biomarkers.

Prasad Shirvalkar, Jordan Prosky, Gregory Chin, Parima Ahmadipour, Omid G Sani, Maansi Desai, Ashlyn Schmitgen, Heather Dawes, Maryam M Shanechi, Philip A Starr, Edward F Chang

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What people are saying

Many discussions highlight the significant findings from the publication, such as the ability to distinguish chronic pain from acute pain through neural activity. For instance, one post emphasizes, 'This is a huge step toward finding a permanent solution to chronic pain,' showing both optimism and excitement. The use of terms like 'huge step' and 'exciting time' communicates enthusiasm and indicates a deep interest in the research's relevance and impact on the field.

AgreementModerate agreement

Most discussions show a supportive stance towards the publication's findings and implications.

InterestHigh interest

Participants express a high level of curiosity about the research and its potential applications in chronic pain treatment.

EngagementModerate engagement

While some posts reiterate the article's title, several contributors delve into the methodologies and significance of the neural biomarkers.

ImpactHigh impact

There is a consensus that the research holds substantial promise for improving chronic pain management.

Abstract in brief

Researchers implanted electrodes in the brains of four individuals with severe neuropathic pain to study their pain levels.
Using machine learning, they were able to predict levels of chronic pain severity based on neural activity captured from the orbitofrontal cortex (OFC).
The findings suggest that changes in brain activity, specifically from the OFC, are distinct for chronic pain and differ from the brain responses associated with acute pain episodes.

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Predicting Chronic Pain Severity Using Brain Implants

Science News discusses groundbreaking research where electrodes were implanted in the brains of individuals with severe neuropathic pain. Using machine learning, researchers predicted chronic pain levels based on neural…

ジャスティスコナカ（東京刺激クラブ） · May 29, 2023 2,202 views

Predicting Chronic Pain with Intracranial Neural Biomarkers

Researchers implanted electrodes in the brains of individuals with severe neuropathic pain to study pain levels. Using machine learning, they predicted levels of chronic pain severity based on neural activity from the…

SOLON OF UK · Jun 16, 2023 134 views

Lifeboat Foundation

@LifeboatHQ · X

First-in-human prediction of chronic pain state using intracranial neural biomarkers https://t.co/Voicp2hpPM

May 5, 2025 · 1 like · 31,615 followers View post →

MU-Peter Shimon

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Chronic pain An expansive view of the debilitating condition First-in-human prediction of chronic pain state using intracranial neural biomarkers

Feb 27, 2025 · 6 likes View post →

MU-Peter Shimon

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Chronic pain causes substantial suffering and disability First-in-human prediction of chronic pain state using intracranial neural biomarkers

Jan 9, 2025 · 10 likes · 3 shares View post →

UCSFPARC

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RT @UCSFAnesthesia: Congratulations to Dr. Prasad Shirvalkar @PrasadShirvalka on his recent @NANS_ION Kumar New Investigator Award! He pre…

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UCSF Anesthesia and Perioperative Care

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Congratulations to Dr. Prasad Shirvalkar @PrasadShirvalka on his recent @NANS_ION Kumar New Investigator Award! He presented his winning manuscript on First-in-human prediction of chronic pain state using intracranial neural biomarkers at the NANS 2024 plenary session. @UCSF https://t.co/PccnGGL4rC

Jan 23, 2024 · 5 likes · 1 share · 4,026 followers View post →

Omar Avliles

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Using intracranial electrodes on specific parts of the brain, scientists were able to distinguish between chronic and acute pain. This is a huge step toward finding a permanent solution to chronic pain. #ChronicPain, #chronicillness, #Neurosurgery https://t.co/WV6OhDbxC8

Oct 17, 2023 · 1 like · 9 followers View post →

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[Nat. Neurosci.] First-in-human prediction of chronic pain state using intracranial neural biomarkers https://t.co/HJtNCvc7H1

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理学療法士_海津陽一 Ph.D.

@copellist · X

■ Ref info: Shirvalkar, Prasad, et al. "First-in-human prediction of chronic pain state using intracranial neural biomarkers." Nature Neuroscience (2023): 1-10. ■ Ref link: https://t.co/CMMYH2ApsT ■ note link: https://t.co/QE7od2WWEz

Jun 3, 2023 · 1 like · 10,560 followers View post →

Dr Imran Sheikh

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First-in-human prediction of chronic pain state using intracranial neural biomarkers https://t.co/zPn6zcOfXR https://t.co/vcCnhML1Zm

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Read #PRF’s Editors Pick article in #PapersoftheWeek on the first-in-human prediction of chronic pain state using intracranial neural biomarkers. https://t.co/HzGCNbFvcb

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Pain Research Forum

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Read #PRF’s Editors Pick article in #PapersoftheWeek on the first-in-human prediction of chronic pain state using intracranial neural biomarkers. https://t.co/C2mXgDTVsA

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IASP

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Read #PRF’s Editors Pick article in #PapersoftheWeek on the first-in-human prediction of chronic pain state using intracranial neural biomarkers. https://t.co/BJbDRxt6yQ

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Read #PRF’s Editors Pick article in #PapersoftheWeek on the first-in-human prediction of chronic pain state using intracranial neural biomarkers. https://t.co/wDEVHUnTnc

Jun 1, 2023 · 1 like · 5,777 followers View post →

PAIN Reports

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New in #PRF #PapersoftheWeek: first-in-human prediction of chronic pain state using intracranial neural biomarkers. https://t.co/wDEVHUnTnc

Jun 1, 2023 · 1 like · 5,777 followers View post →

ReliefNews

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New in #PRF #PapersoftheWeek: first-in-human prediction of chronic pain state using intracranial neural biomarkers. https://t.co/HzGCNbFvcb

Jun 1, 2023 · 2,192 followers View post →

Pain Research Forum

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New in #PRF #PapersoftheWeek: first-in-human prediction of chronic pain state using intracranial neural biomarkers. https://t.co/C2mXgDTVsA

Jun 1, 2023 · 15,357 followers View post →

PAIN Journal

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New in #PRF #PapersoftheWeek: first-in-human prediction of chronic pain state using intracranial neural biomarkers. https://t.co/S3SUtlj8aR

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IASP

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New in #PRF #PapersoftheWeek: first-in-human prediction of chronic pain state using intracranial neural biomarkers. https://t.co/BJbDRxt6yQ

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Ｔｏｈｒｕ　Ｈａｓｅｇａｗａ

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It reported that it had discovered the pain signal for the first time by now. We have been reporting this for 13 years. PLoS ONE. Nature Neurosciencenature https://t.co/hszgWEv3ux human prediction of chronic pain state using intracranial neural biomarkers

May 29, 2023 · 78 followers View post →

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RT @Retlouping: https://t.co/6jbOdffzgM First in human prediction of chronic pain state using intracranial neural bio markers https://t.co/…

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First-in-human prediction of chronic pain state using intracranial neural biomarkers | Nature Neuroscience https://t.co/AwDOHyXmXP

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NATURE / First-in-human prediction of chronic pain state using intracranial neural biomarkers https://t.co/wvtcNICqh3

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First-in-human prediction of chronic pain state using intracranial neural biomarkers | Nature Neuroscience https://t.co/zglJysS8uB

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First-in-human prediction of chronic pain state using intracranial neural biomarkers https://t.co/zGRSFz9IHl

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US Association for the Study of Pain

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Michael Vianin

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Thus, intracranial OFC signals can be used to predict spontaneous, chronic pain state in patients. First-in-human prediction of chronic pain state using intracranial neural biomarkers - PubMed - https://t.co/x7pDJ4OgYf

May 23, 2023 · 129 followers View post →

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First-in-human prediction of chronic pain state using intracranial neural biomarkers | Nature Neuroscience https://t.co/ObNOkjMXBE

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First-in-human prediction of chronic pain state using intracranial neural biomarkers | Nature Neuroscience https://t.co/6918suqxle

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First-in-human prediction of chronic pain state using intracranial neural biomarkers. https://t.co/Cx1hqud4tP

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First-in-human prediction of chronic pain state using intracranial neural biomarkers.

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Abstract in brief

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All mentions

Predicting Chronic Pain Severity Using Brain Implants

Predicting Chronic Pain with Intracranial Neural Biomarkers