Microbiology (Reading) May 2023 PMID 37226834

Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool.

David Sünderhauf, Uli Klümper, Elizabeth Pursey, Edze R Westra, William H Gaze, Stineke van Houte

Mentions

67
Peak: 27 in May 2023
across 4 sources since May 2023

Extended reach

174,896
potential audience

Total likes

159

Video views

20,946

Mentions per month

May 2023 – Nov 2023

Where it's discussed

  • X / Twitter37 posts
  • News24 articles
  • Blogs4 articles
  • YouTube2 videos

AI synopsis

What people are saying

Several comments highlight the promising nature of the research, describing it as an 'exciting breakthrough' and 'very cool,' which illustrates enthusiasm for the potential impact of the CRISPR-based tool. The tone varies from curiosity—questioning whether CRISPR will be 'revolutionary'—to optimism about its applications, emphasizing its transformative potential and high relevance in the fight against antimicrobial resistance.

AgreementModerate agreement

Most discussions express support or enthusiasm for the research, with comments calling it an 'exciting breakthrough' and 'promising,' indicating general agreement on its significance.

InterestHigh interest

The posts frequently highlight the novelty and potential of the approach, such as asking if CRISPR will be 'revolutionary' and emphasizing the development of new tools, demonstrating high curiosity and relevance.

EngagementModerate engagement

Some posts delve into specific details like the broad host-range capability and its implications, reflecting a moderate level of deeper engagement beyond mere acknowledgment.

ImpactHigh impact

Many posts emphasize the potential impact on combating antimicrobial resistance globally, describing the technology as 'very cool' and 'a step towards reducing' resistance, indicating perceived high importance.

Abstract in brief

  • The study developed a broad host range CRISPR-Cas9 delivery plasmid, called pKJK5csg, designed to target and remove antimicrobial resistance (AMR) genes carried on plasmids across various bacteria.
  • pKJK5csg was shown to effectively prevent the uptake of AMR plasmids and remove existing resistance plasmids from bacteria, including those from complex microbial communities like pig and human-associated bacteria.
  • This research highlights pKJK5csg as a promising tool for tackling the spread of AMR genes in diverse bacterial populations, potentially helping to reduce antimicrobial resistance in the environment and clinical settings.]

Top posts

Most liked on X and Bluesky
Tue Kjærgaard Nielsen
@tueknielsen · X

This is cool! CRISPR-mediated removal of AMR plasmids via an engineered broad host-range plasmid. Here's to new tools against antibiotic resistant bacteria. https://t.co/EQxaoesBIl

May 25, 2023 · 33 likes · 9 shares · 130 followers View post →
Laura Piddock
@LauraPiddock · X

Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool - https://t.co/ls0Ajttlmt

Jun 7, 2023 · 25 likes · 6 shares · 10,272 followers View post →
Paul Hoskisson
@PaulHoskisson · X

This is very cool from @davvi36 @UliKluemper @ElliePursey @edzewestra @WillHGaze & @StinekevanHoute Removal of #AMR #plasmids using a mobile, broad host-range #CRISPR-Cas9 delivery tool https://t.co/JddtT7kNxY #PublishingForTheCommunity @MicrobioSoc

May 26, 2023 · 17 likes · 8 shares · 9,214 followers View post →
Emily Stevenson
@E_StevensonBG · X

Jul 17, 2023 · 5 likes · 1,055 followers View post →
CRISP_SCIENCE
@ScienceCrisp · X

"Removal of AMR plasmids using a mobile, broad host-range #CRISPR-Cas9 delivery tool" Walker-Sünderhauf D [..] van House S. Microbiology (Reading). 2023-05:25. https://t.co/0HaukI6fvw https://t.co/QaUz5NyuMs

May 29, 2023 · 2 likes · 1 share · 1,917 followers View post →
jenniferwalters
@susanstorm62 · X

Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool https://t.co/8TKcbWR3Az https://t.co/PjlidLcLea

May 28, 2023 · 1 like · 510 followers View post →

All mentions

KnowledgeBrief
@FinnKarste52749 · X

Is CRISPR going to be revolutionary?! https://t.co/plYz5heqQ0 via @YouTube

Nov 16, 2023 · 11 followers View post →
Emily Stevenson
@E_StevensonBG · X

Jul 17, 2023 · 5 likes · 1,055 followers View post →
MISTAR_JPIAMR
@MISTAR_JPIAMR · X

RT @LauraPiddock: Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool - https://t.co/ls0Ajttlmt

Jun 12, 2023 · 6 shares · 54 followers View post →
Samantha McKeand
@SammiMcKeand · X

RT @LauraPiddock: Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool - https://t.co/ls0Ajttlmt

Jun 7, 2023 · 6 shares · 352 followers View post →
MD ALAMIN
@MDALAMI79531793 · X

RT @LauraPiddock: Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool - https://t.co/ls0Ajttlmt

Jun 7, 2023 · 6 shares · 6 followers View post →
Daniel F. M. do Monte
@MonteDFM · X

RT @LauraPiddock: Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool - https://t.co/ls0Ajttlmt

Jun 7, 2023 · 6 shares · 49 followers View post →
Sid Chopra
@skchopra007 · X

RT @LauraPiddock: Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool - https://t.co/ls0Ajttlmt

Jun 7, 2023 · 6 shares · 940 followers View post →
A/Prof Amy Cain
@flamycain · X

RT @LauraPiddock: Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool - https://t.co/ls0Ajttlmt

Jun 7, 2023 · 6 shares · 1,660 followers View post →
Laura Piddock
@LauraPiddock · X

Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool - https://t.co/ls0Ajttlmt

Jun 7, 2023 · 25 likes · 6 shares · 10,272 followers View post →
Phages & Crisprs
@CrisprPhages · X

Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool https://t.co/2c1dCUYncx

Jun 4, 2023 · 185 followers View post →
@MicrobioJC@scicomm.xyz
@microtwjc · X

In case you don't follow us on our @scicomm.xyz account, here's a head's up that we're going to be doing a news show on Jun 4th. We'd love to see you in the chat! https://t.co/vgxHEBBZXS Longer post here: https://t.co/6nwt5WOqtF

May 30, 2023 · 302 followers View post →
NCCR AntiResist
@NCCR_AntiResist · X

Paper in @MicrobioSoc discusses promising tool for gene editing tool to counter spread of #AMR https://t.co/NazXQEeWjO

May 30, 2023 · 1,224 followers View post →
ぜのぱす(初代_凍結から快復)
@Xenopus007 · X

RT @ScienceCrisp: "Removal of AMR plasmids using a mobile, broad host-range #CRISPR-Cas9 delivery tool" Walker-Sünderhauf D [..] van House…

May 30, 2023 · 1 share · 855 followers View post →
CRISP_SCIENCE
@ScienceCrisp · X

"Removal of AMR plasmids using a mobile, broad host-range #CRISPR-Cas9 delivery tool" Walker-Sünderhauf D [..] van House S. Microbiology (Reading). 2023-05:25. https://t.co/0HaukI6fvw https://t.co/QaUz5NyuMs

May 29, 2023 · 2 likes · 1 share · 1,917 followers View post →
jenniferwalters
@susanstorm62 · X

Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool https://t.co/8TKcbWR3Az https://t.co/PjlidLcLea

May 28, 2023 · 1 like · 510 followers View post →
RiseAndResist
@FrontLineExHero · X

RT @shrawan7197: "Exciting breakthrough in the fight against AMR! Researchers at @UniofExeter have developed a C-Cas9-based plasmid that ta…

May 28, 2023 · 1 share · 1,633 followers View post →
Gilles van Wezel
@GillesvanWezel · X

RT @PaulHoskisson: This is very cool from @davvi36 @UliKluemper @ElliePursey @edzewestra @WillHGaze & @StinekevanHoute Removal of #AMR #p…

May 28, 2023 · 8 shares · 4,332 followers View post →
Shrawan choudhary
@shrawan7197 · X

"Exciting breakthrough in the fight against AMR! Researchers at @UniofExeter have developed a C-Cas9-based plasmid that targets antibiotic-resistant genes, protecting host cells and reversing resistance. A promising step towards reducing global AMR. 10.1099/mic.0.001334 #AMR

May 28, 2023 · 1 like · 1 share · 9 followers View post →
Єl Єรקy
@FranEspy · X

RT @PaulHoskisson: This is very cool from @davvi36 @UliKluemper @ElliePursey @edzewestra @WillHGaze & @StinekevanHoute Removal of #AMR #p…

May 26, 2023 · 8 shares · 105 followers View post →
José R Penadés
@jrpenades · X

RT @PaulHoskisson: This is very cool from @davvi36 @UliKluemper @ElliePursey @edzewestra @WillHGaze & @StinekevanHoute Removal of #AMR #p…

May 26, 2023 · 8 shares · 3,046 followers View post →
Ivy Mutai
@MutaiIvy · X

RT @tueknielsen: This is cool! CRISPR-mediated removal of AMR plasmids via an engineered broad host-range plasmid. Here's to new tools aga…

May 26, 2023 · 9 shares · 2,363 followers View post →
Zamin Iqbal
@ZaminIqbal · X

RT @PaulHoskisson: This is very cool from @davvi36 @UliKluemper @ElliePursey @edzewestra @WillHGaze & @StinekevanHoute Removal of #AMR #p…

May 26, 2023 · 8 shares · 9,490 followers View post →
Microbiology Society
@MicrobioSoc · X

RT @PaulHoskisson: This is very cool from @davvi36 @UliKluemper @ElliePursey @edzewestra @WillHGaze & @StinekevanHoute Removal of #AMR #p…

May 26, 2023 · 8 shares · 76,165 followers View post →
Gavin H Thomas
@GavinHThomas · X

RT @PaulHoskisson: This is very cool from @davvi36 @UliKluemper @ElliePursey @edzewestra @WillHGaze & @StinekevanHoute Removal of #AMR #p…

May 26, 2023 · 8 shares · 4,581 followers View post →
Paul Hoskisson
@PaulHoskisson · X

This is very cool from @davvi36 @UliKluemper @ElliePursey @edzewestra @WillHGaze & @StinekevanHoute Removal of #AMR #plasmids using a mobile, broad host-range #CRISPR-Cas9 delivery tool https://t.co/JddtT7kNxY #PublishingForTheCommunity @MicrobioSoc

May 26, 2023 · 17 likes · 8 shares · 9,214 followers View post →
Pablo Vinuesa
@pvinmex · X

RT @tueknielsen: This is cool! CRISPR-mediated removal of AMR plasmids via an engineered broad host-range plasmid. Here's to new tools aga…

May 25, 2023 · 9 shares · 1,580 followers View post →
Microbiology@UCL
@MICROBIOLOGYUCL · X

RT @tueknielsen: This is cool! CRISPR-mediated removal of AMR plasmids via an engineered broad host-range plasmid. Here's to new tools aga…

May 25, 2023 · 9 shares · 1,977 followers View post →
Mohan Amarasiri
@MohanAmarasiri · X

RT @tueknielsen: This is cool! CRISPR-mediated removal of AMR plasmids via an engineered broad host-range plasmid. Here's to new tools aga…

May 25, 2023 · 9 shares · 226 followers View post →
Lori L. Burrows
@Dr_Lori_Burrows · X

RT @tueknielsen: This is cool! CRISPR-mediated removal of AMR plasmids via an engineered broad host-range plasmid. Here's to new tools aga…

May 25, 2023 · 9 shares · 4,713 followers View post →
Wiep Klaas Smits
@SmitsLab · X

RT @tueknielsen: This is cool! CRISPR-mediated removal of AMR plasmids via an engineered broad host-range plasmid. Here's to new tools aga…

May 25, 2023 · 9 shares · 2,357 followers View post →
Afif Pranaya Jati
@afifpj · X

RT @tueknielsen: This is cool! CRISPR-mediated removal of AMR plasmids via an engineered broad host-range plasmid. Here's to new tools aga…

May 25, 2023 · 9 shares · 1,141 followers View post →
Ace Bryan Sotelo Cabal
@ace_cabal · X

RT @tueknielsen: This is cool! CRISPR-mediated removal of AMR plasmids via an engineered broad host-range plasmid. Here's to new tools aga…

May 25, 2023 · 9 shares · 1,133 followers View post →
Phys.org Biology
@physorg_biology · X

Gene editing tool could help reduce spread of #antimicrobialresistance @uniofexeter https://t.co/Q5hTwZpBZ4 https://t.co/UhGg7osDpI

May 25, 2023 · 8,219 followers View post →
Tue Kjærgaard Nielsen
@tueknielsen · X

This is cool! CRISPR-mediated removal of AMR plasmids via an engineered broad host-range plasmid. Here's to new tools against antibiotic resistant bacteria. https://t.co/EQxaoesBIl

May 25, 2023 · 33 likes · 9 shares · 130 followers View post →
viralecologypapers
@viraleco_papers · X

Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool https://t.co/U2UAoqsSVS https://t.co/s3IVWzpFF7

May 25, 2023 · 4 followers View post →
Oleg A. Chagin
@Oleg_A_Chagin · X

Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool | Microbiology Society https://t.co/aDIFEZIA0x

May 25, 2023 · 1,128 followers View post →
Phage Papers
@Phage_Papers · X

Removal of AMR plasmids using a mobile, broad host-range CRISPR-Cas9 delivery tool https://t.co/IyIqEDJhOX

May 25, 2023 · 647 followers View post →