May 2023 PMID 37231000

The blood-brain barrier: structure, regulation, and drug delivery.

Di Wu, Qi Chen, Xiaojie Chen, Feng Han, Zhong Chen, Yi Wang

Mentions

53
Peak: 4 in Aug 2023
across 4 sources since May 2023

Extended reach

110,494
potential audience

Total likes

1,120

Video views

46,737

Mentions per month

May 2023 – Aug 2025

Where it's discussed

  • News35 articles
  • Blogs8 articles
  • X / Twitter7 posts
  • YouTube3 videos

AI synopsis

What people are saying

The conversations mainly revolve around sharing the publication and related hashtags, with some posts mentioning specific substances used to cross the BBB, highlighting curiosity but not deep analysis. Words like 'see this' and brief mentions suggest a foundational interest rather than active engagement or debate.

AgreementNeither agree nor disagree

The discussions show recognition of the importance of the BBB and the research, but no strong consensus or disagreement is evident.

InterestModerate interest

There is moderate curiosity about the topic, suggested by mentions of the publication and related keywords, but limited in-depth exploration.

EngagementNeutral engagement

Most comments are brief, such as sharing links or asking if others have seen the work, indicating low to moderate engagement.

ImpactNeutral impact

The discussions reflect an awareness of the research but don't indicate that it has a transformative or widespread impact yet.

Abstract in brief

  • The blood-brain barrier (BBB) is a protective membrane that blocks toxins and pathogens from entering the central nervous system, but it also makes delivering drugs to the brain challenging, leading to low treatment efficacy and side effects.
  • Advances in nanotechnology and materials science have created new tools for targeted drug delivery across the BBB, supported by in-depth research on brain and BBB structure to develop effective crossing strategies.
  • The review discusses various methods for overcoming BBB barriers—including passive transcytosis, intranasal delivery, ligand conjugation, and membrane coating—and summarizes different drug delivery systems designed to enhance brain targeting and crossing.]

Top posts

Most liked on X and Bluesky
Sabine Stebel
@Sabisteb · X

@teyanos9 Daher werden “Stoffe wie Metalle, Polysorbat-80 (PS-80) usw. verwendet, um die Endothelzellen des Gehirns zu schrumpfen. Mit dieser Behandlung könnten verschiedene Arzneimittelabgabesysteme die Blut-Hirn-Schranke umgehen.” https://t.co/ajVB7PWKS0

Aug 26, 2025 · 2 likes · 5,454 followers View post →
Louie PSSD
@louieNebula · X

@MoralMedicine https://t.co/QCvjfXSWXb You seen this mark?

Sep 24, 2024 · 1 like · 513 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

RT @_Sivasai: The blood–brain barrier: structure, regulation, and drug delivery https://t.co/M9J04biFlo #CNS #Brainresearch #neuro #Neuro…

Aug 17, 2023 · 2 shares · 44,463 followers View post →
Chidambara .ML.
@chidambara09 · X

RT @_Sivasai: The blood–brain barrier: structure, regulation, and drug delivery https://t.co/M9J04biFlo #CNS #Brainresearch #neuro #Neuro…

Aug 10, 2023 · 2 shares · 11,721 followers View post →
Blood brain barrier
@bbbpapers · X

The blood-brain barrier: structure, regulation, and drug delivery https://t.co/ebEGSpiGPu

May 26, 2023 · 775 followers View post →
Signal Transduction and Targeted Therapy (STTT)
@sigtrans_sttt · X

The blood–brain barrier: structure, regulation, and drug delivery #bloodbrainbarrier #MedTwitter #openaccess https://t.co/IQtPqkOyu1

May 30, 2023 · 473 followers View post →

All mentions

Sabine Stebel
@Sabisteb · X

@teyanos9 Daher werden “Stoffe wie Metalle, Polysorbat-80 (PS-80) usw. verwendet, um die Endothelzellen des Gehirns zu schrumpfen. Mit dieser Behandlung könnten verschiedene Arzneimittelabgabesysteme die Blut-Hirn-Schranke umgehen.” https://t.co/ajVB7PWKS0

Aug 26, 2025 · 2 likes · 5,454 followers View post →
Louie PSSD
@louieNebula · X

@MoralMedicine https://t.co/QCvjfXSWXb You seen this mark?

Sep 24, 2024 · 1 like · 513 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

RT @_Sivasai: The blood–brain barrier: structure, regulation, and drug delivery https://t.co/M9J04biFlo #CNS #Brainresearch #neuro #Neuro…

Aug 17, 2023 · 2 shares · 44,463 followers View post →
Chidambara .ML.
@chidambara09 · X

RT @_Sivasai: The blood–brain barrier: structure, regulation, and drug delivery https://t.co/M9J04biFlo #CNS #Brainresearch #neuro #Neuro…

Aug 10, 2023 · 2 shares · 11,721 followers View post →
Siva Sai
@_Sivasai · X

The blood–brain barrier: structure, regulation, and drug delivery https://t.co/M9J04biFlo #CNS #Brainresearch #neuro #NeuroTwitter #neuroscience #neurology #Brains #BrainFunction #brainhealth #scicomm #NPMND #neurologia #CardioTwitter #MedTwitter #MedEd #ScienceTwitter #Science

Aug 10, 2023 · 2 shares · 346 followers View post →
Signal Transduction and Targeted Therapy (STTT)
@sigtrans_sttt · X

The blood–brain barrier: structure, regulation, and drug delivery #bloodbrainbarrier #MedTwitter #openaccess https://t.co/IQtPqkOyu1

May 30, 2023 · 473 followers View post →
Blood brain barrier
@bbbpapers · X

The blood-brain barrier: structure, regulation, and drug delivery https://t.co/ebEGSpiGPu

May 26, 2023 · 775 followers View post →