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Front Endocrinol (Lausanne) May 2023 PMID 37234812

Hyaluronan regulates sperm-induced inflammatory response by enhancing sperm attachment to bovine endometrial epithelial cells CD44: and approaches.

Mohamed Aboul Ezz, Alireza Mansouri, Ihshan Akthar, Mohamed Samy Yousef, Rasoul Kowsar, Akio Miyamoto

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Mentions

3
Peak: 2 in May 2023
across 2 sources since May 2023

Extended reach

5,379
potential audience

Total likes

2

Video views

17

Mentions per month

May 2023 – Aug 2023

Where it's discussed

  • X / Twitter2 posts
  • YouTube1 videos

AI synopsis

What people are saying

Discussions reflect a general appreciation of the study's importance, with phrases like 'recently reported' and references to specific mechanisms such as HA binding to CD44 and its influence on inflammation. The tone is analytical yet straightforward, suggesting moderate engagement and interest in the biological insights and potential applications uncovered by the research.

AgreementModerate agreement

Most discussions recognize the importance of the findings regarding hyaluronan's role in sperm attachment and inflammation, aligning with the publication's conclusions.

InterestModerate interest

The discussions demonstrate moderate interest, as shown by their focus on the biological mechanisms and potential implications, though they lack deep curiosity or critique.

EngagementModerate engagement

Participants engage with the research through mentions of specific methods like in-silico modeling and in-vitro approaches, showing a thoughtful but not highly detailed engagement.

ImpactModerate impact

The conversations hint at meaningful implications for reproductive biology and possibly fertility treatments, indicating a moderate perceived impact.

Abstract in brief

  • The study investigated how hyaluronan (HA) interacts with bovine endometrial epithelial cells (BEECs) and its role in sperm attachment and inflammation, focusing on receptor interactions involving CD44 and TLR2.
  • Experiments showed that HA binds strongly to CD44 and influences sperm attachment to BEECs, increasing inflammatory responses, as demonstrated by higher proinflammatory gene expression after HA pretreatment.
  • In silico modeling indicated specific interactions of HA with TLR2, but only certain HA fragments (32mers) were unstable within TLR2, and overall, HA enhances sperm adhesion and inflammation in the bovine uterus context.]
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Top posts

Most liked on X and Bluesky
Frontiers - Endocrinology
@FrontEndocrinol · X

New Research: Hyaluronan regulates sperm-induced inflammatory response by enhancing sperm attachment to bovine endometrial epithelial cells via CD44: in-silico and in-vitro approaches: Recently, we reported that sperm induce cluster… #Endocrinology #Endo https://t.co/OJdVcX26mT

May 10, 2023 · 2 likes · 1 share · 5,050 followers View post →
DrMadan11
@DrMadan11 · X

RT @FrontEndocrinol: New Research: Hyaluronan regulates sperm-induced inflammatory response by enhancing sperm attachment to bovine endomet…

May 10, 2023 · 1 share · 309 followers View post →

All mentions

DrMadan11
@DrMadan11 · X

RT @FrontEndocrinol: New Research: Hyaluronan regulates sperm-induced inflammatory response by enhancing sperm attachment to bovine endomet…

May 10, 2023 · 1 share · 309 followers View post →
Frontiers - Endocrinology
@FrontEndocrinol · X

New Research: Hyaluronan regulates sperm-induced inflammatory response by enhancing sperm attachment to bovine endometrial epithelial cells via CD44: in-silico and in-vitro approaches: Recently, we reported that sperm induce cluster… #Endocrinology #Endo https://t.co/OJdVcX26mT

May 10, 2023 · 2 likes · 1 share · 5,050 followers View post →