May 2023 PMID 37239045

STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases.

Alex S Ferecskó, Miranda J Smallwood, Adrian Moore, Corin Liddle, Jia Newcombe, Janet Holley, Jacqueline Whatmore, Nicholas J Gutowski, Paul Eggleton

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Peak: 3 in Mar 2025

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May 2023 – Sep 2025

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The overall tone is neutral to positive, with users using phrases such as 'recommended paper' and '#MustRead,' showing interest but not deep involvement. The participation involves sharing links, hashtags, and brief acknowledgments rather than detailed critiques, reflecting moderate engagement and perceived relevance without strong agreement or high impact.

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Abstract in brief

The cGAS-STING pathway, which is activated by microbial or host DNA, plays a role in triggering neuroinflammation in neurodegenerative diseases such as Alzheimer's, Parkinson's, ALS, and multiple sclerosis, with elevated STING levels found mainly in brain endothelial cells and neurons.
In human brain tissues, increased STING protein correlates with toxic protein aggregates and demyelinating lesions, suggesting its involvement in disease pathology.
Experimental activation of the pathway with palmitic acid in brain endothelial cells induces mitochondrial stress and inflammatory responses, indicating that metabolic stress can also activate the cGAS-STING pathway beyond microbial triggers.]

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Targeting cGAS-STING Pathway in Alzheimer’s Disease Treatment

Explore how the cGAS-STING signaling pathway plays a key role in immune response and neurodegeneration. Discover natural compounds and lifestyle factors that influence this pathway to potentially slow or halt…

Vital Aging Lab · May 20, 2024 207 views

Targeting cGAS-STING Pathway to Prevent Neurodegeneration

Explore how the cGAS-STING signaling pathway influences immune responses and neurodegeneration, highlighting potential natural compounds and lifestyle factors that could slow or halt neurodegenerative processes.

Vital Aging World · Jun 8, 2024 54 views

MDPI Biology

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#recommendedpaper #MustRead #IndustryTrends #InsightfulRead Today's recommended article is as follows:

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UCL Discovery

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Open Access UCL Research: STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases https://t.co/QpQ9iSg0Pe

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RT @krista_rantanen: STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases: https://t.co/XM6oEsmqWk #mdpibiomedicines via @B…

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Dr Ox

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STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases: https://t.co/XM6oEsmqWk #mdpibiomedicines via @Biomed_MDPI

May 11, 2023 · 3 likes · 1 share · 1,287 followers View post →

STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases.

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Abstract in brief

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All mentions

Targeting cGAS-STING Pathway in Alzheimer’s Disease Treatment

Targeting cGAS-STING Pathway to Prevent Neurodegeneration