ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins.

Brennan Abanades, Wing Ki Wong, Fergus Boyles, Guy Georges, Alexander Bujotzek, Charlotte M Deane

May 2023 Commun Biol

Synopsis of Social media discussions

The discussions highlight the technical superiority of ImmuneBuilder, with many emphasizing its faster and more accurate predictions compared to prior models, as seen in comments about 'outperforming AlphaFold' and 'supporting research.' Users use positive language like 'game changer' and 'important development' to convey recognition of its potential influence in immunology and drug discovery, reflecting high interest and moderate impact perceptions.

A
Agreement
 Moderate agreement

Most discussions reflect strong support and positive acknowledgment of the publication's advancements, with phrases like 'accurately predict' and 'outperform existing tools' indicating broad agreement.

I
Interest
 High level of interest

Participants demonstrate high curiosity, frequently mentioning technical details, such as the models' speed and accuracy, showing they find the research engaging.

E
Engagement
 Moderate level of engagement

The discussions include references to related topics like immunotherapy, biotherapeutics, and existing models, showing a meaningful level of engagement beyond surface-level mentions.

I
Impact
 Moderate level of impact

While some express optimism about the potential applications in medicine and research, the overall tone indicates a recognition of moderate but important scientific impact rather than revolutionary change.

Social Mentions

YouTube

1 Videos

Twitter

22 Posts

Metrics

Video Views

38

Total Likes

46

Extended Reach

201,975

Social Features

23

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

ImmuneBuilder Deep-Learning for Immune Protein Structure Prediction

ImmuneBuilder Deep-Learning for Immune Protein Structure Prediction

ImmuneBuilder uses deep learning models to quickly and accurately predict immune protein structures, outperforming existing tools like AlphaFold2, and supports immunology research and drug development. The models are freely available online.

Social RTCL TV

September 29, 2023

38 views

  • manu
    @weakcoalgebra (Twitter)

    RT @CommsBio: ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins https://t.co/oHCxVmNblR
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    October 13, 2024

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  • Communications Biology
    @CommsBio (Twitter)

    ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins https://t.co/oHCxVmNblR
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    October 10, 2024

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  • Oxford Protein Informatics Group (OPIG)
    @OPIGlets (Twitter)

    Immunebuilder: deep-learning models for predicting the structures of immune proteins (also talk) @brennanaba Paired Antibody Sequence Generation: A Deep Generative Language Model for the Creation of Highly Developable Libraries @oliverturnbull1 2/4
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    July 24, 2023

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  • fangxiang
    @Realorientation (Twitter)

    RT @CAR_TCell: ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins: https://t.co/xtvhstmUr5 #CARTCR #immun…
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    June 9, 2023

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  • lbgbox
    @lbgbox (Twitter)

    RT @CAR_TCell: ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins: https://t.co/xtvhstmUr5 #CARTCR #immun…
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    June 9, 2023

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  • CancerLinks 
    @CancerLinks (Twitter)

    RT @CAR_TCell: ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins: https://t.co/xtvhstmUr5 #CARTCR #immun…
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    June 8, 2023

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  • John Kenten
    @JohnKenten (Twitter)

    RT @CAR_TCell: ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins: https://t.co/xtvhstmUr5 #CARTCR #immun…
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    June 8, 2023

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  • CAR-TCR
    @CAR_TCell (Twitter)

    ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins: https://t.co/xtvhstmUr5 #CARTCR #immunotherapy
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    June 8, 2023

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    June 1, 2023

  • Anjali Kusumbe
    @KusumbeLab (Twitter)

    RT @hashemkoohy: ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins | Communications Biology https://t.co…
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    May 31, 2023

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  • John Andrew Todd
    @ProfJohnATodd (Twitter)

    RT @hashemkoohy: ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins | Communications Biology https://t.co…
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    RT @hashemkoohy: ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins | Communications Biology https://t.co…
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    May 31, 2023

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  • Hoffman
    @SPDFHoffman (Twitter)

    ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins. Deep learning models trained to accurately predict the structure of antibodies, nanobodies, and T-Cell receptors. https://t.co/lp0duhELja #science #medicine #Immunology
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    May 31, 2023

  • Malcolm Sim
    @mjwsim (Twitter)

    RT @hashemkoohy: ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins | Communications Biology https://t.co…
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    May 30, 2023

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    @hashemkoohy (Twitter)

    ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins | Communications Biology https://t.co/cQxYoPSNEr
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    May 30, 2023

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  • OxASN: The Oxford Antigen Specificity Network
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    ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins | Communications Biology https://t.co/WWCgCAPZYo
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    May 30, 2023

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  • know thyself（子豚のオリバー)
    @thyself_know (Twitter)

    RT @oxkawaka: ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins https://t.co/sek2ajCdVL
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    May 30, 2023

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  • Kato
    @oxkawaka (Twitter)

    ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins https://t.co/sek2ajCdVL
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    May 30, 2023

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  • hashem
    @hashemkoohy (Twitter)

    ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins. | bioRxiv https://t.co/U56G8UGRsx
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    November 7, 2022

  • Helio Rocha
    @_elioRocha (Twitter)

    #bioRxiv ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins. #bioinfo https://t.co/muRX1wOs1Y
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    November 5, 2022

  • bioRxiv Bioinfo
    @biorxiv_bioinfo (Twitter)

    ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins. https://t.co/K4TKkXIC43 #biorxiv_bioinfo
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    November 5, 2022

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    ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins. https://t.co/CmQHJYuCns #bioRxiv
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    November 5, 2022

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Abstract Synopsis

  • ImmuneBuilder is a set of deep learning models designed to accurately and quickly predict the structures of immune proteins like antibodies, nanobodies, and T-cell receptors, which are important for understanding immune responses and developing biotherapeutics.
  • The models outperform existing tools such as AlphaFold2 and AlphaFoldMultimer in both accuracy and speed, providing detailed structural predictions including error estimates for individual residues.
  • ImmuneBuilder is freely accessible through download and a web server, and also offers structural models for a large database of antibody sequences, supporting research and drug development in immunology.]