Nat Commun June 2023 PMID 37264049

Identification of a covert evolutionary pathway between two protein folds.

Devlina Chakravarty, Shwetha Sreenivasan, Liskin Swint-Kruse, Lauren L Porter

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Peak: 29 in Jun 2023

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The discussions reveal a strong interest in the scientific implications, as posters mention concepts like mutations, transcription factors, and protein fold switching. Words like 'advance,' 'potential,' and 'significance' illustrate the recognition of the research's importance, while technical references to phylogenetic analysis and structural modeling suggest deeper engagement with the methodology and findings.

AgreementModerate agreement

Most posts acknowledge the significance of the research, viewing it as an important discovery, though some express cautious optimism rather than full enthusiasm.

InterestHigh interest

Posts indicate high curiosity, with discussions highlighting new insights into protein evolution and potential links to broader biological processes, as seen in references to mutations, DNA-binding, and disease implications.

EngagementModerate engagement

Some posters delve into technical aspects, such as structural modeling and evolutionary pathways, showing meaningful engagement beyond surface-level reactions.

ImpactModerate impact

The perceived impact is moderate, with mentions of potential biomedical applications (e.g., obesity and diabetes treatments) and fundamental scientific advances, but some posts seem to focus more on the research's novelty than concrete outcomes.

Abstract in brief

The study explores how certain amino acid changes can cause proteins to switch between different structures, specifically between helix-turn-helix and winged helix DNA-binding folds, across evolutionary history.
Researchers used advanced statistical methods, including phylogenetic analysis and AlphaFold2 modeling, on a large dataset of 600,000 bacterial response regulator proteins to uncover evidence of this structural transition.
This discovery suggests that such fold switching has likely increased DNA-binding versatility and demonstrates a new approach to identify similar structural evolutions in other protein families.]

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Uncovering Hidden Evolutionary Transitions Between Protein Folds

This video explores how amino acid changes can cause proteins to switch structures, specifically between helix-turn-helix and winged helix DNA-binding folds, across evolutionary history. Using phylogenetic analysis and…

STEM RTCL TV · Sep 23, 2023 20 views

Andri Achilleos

@AchilleosMs · X

RT @BeaulieuBio: Identification of a covert evolutionary pathway between two protein folds | Nature Communications ⁦@KJF239⁩ a ⁦@molstar0⁩…

Jul 3, 2023 · 3 shares · 137 followers View post →

head-in-the-clouds.bsky.social

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RT @BeaulieuBio: Identification of a covert evolutionary pathway between two protein folds | Nature Communications ⁦@KJF239⁩ a ⁦@molstar0⁩…

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Jon Hale

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Jul 1, 2023 · 8 likes · 3 shares · 2,589 followers View post →

Silvia Ramundo

@ramundo_silvia · X

Identification of a covert evolutionary pathway between two protein folds https://t.co/GxfcPheZ3A

Jun 18, 2023 · 2 likes · 2,626 followers View post →

Animalcules

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Identification of a covert evolutionary pathway between two protein folds https://t.co/pBmub8HpQJ

Jun 18, 2023 · 520 followers View post →

GAMA Miguel Angel

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RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

Jun 10, 2023 · 19 shares · 1,506 followers View post →

Nicolas Lux Fawzi

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RT @ShorterLab: Identification of a covert evolutionary pathway between two protein folds: https://t.co/nN5LMzWr0M

Jun 7, 2023 · 5 shares · 721 followers View post →

Tominaga K. (tomiken)

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» Identification of a covert evolutionary pathway between two protein folds | Nature Communications https://t.co/gOUL5sM9Xh

Jun 7, 2023 · 855 followers View post →

Gonzalo Parra

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RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

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Elizabet Monteagudo Cascales

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RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

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Hoffman

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Identification of a covert evolutionary pathway between two protein folds. The molecular structure of a protein that allows ''good fat'' to burn off calories, an advance that could lead to treatments for obesity and diabetes. https://t.co/nYRgyxgX7n

Jun 3, 2023 · 8 followers View post →

Unn-frid

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RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

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Chengwei Zhang

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RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

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Rong Li

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RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

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adeliebiology

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RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

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Vamsi Bharadwaj

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RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

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Elodie Laine

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RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

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Cesar Ramirez-Sarmiento @cesarramirez.bsky.social

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RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

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Saikat

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RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

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Molecular Microbiology

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RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

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2438@ROM

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RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

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Noelia Ferruz

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RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

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ShunsukeTAGAMI

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RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

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Black In Biophysics

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RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

Jun 1, 2023 · 19 shares · 2,820 followers View post →

juice like

@Bactosafe · X

RT @ShorterLab: Identification of a covert evolutionary pathway between two protein folds: https://t.co/nN5LMzWr0M

Jun 1, 2023 · 5 shares · 38 followers View post →

Gabriel Rocklin

@grocklin · X

RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

Jun 1, 2023 · 19 shares · 2,622 followers View post →

Magnetic Resonance News

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RT @Lauren_L_Porter: Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

Jun 1, 2023 · 19 shares · 6,110 followers View post →

Lauren Porter

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Happy to share our latest paper published in @NatureComms. https://t.co/FE122uaxb4

Jun 1, 2023 · 93 likes · 19 shares · 938 followers View post →

J. Fernando Bazan @jfernandobazan.bsky.social

@jfernandobazan · X

RT @ShorterLab: Identification of a covert evolutionary pathway between two protein folds: https://t.co/nN5LMzWr0M

Jun 1, 2023 · 5 shares · 705 followers View post →

Jose J. Gorbea Colón, PhD

@josejgorbea · X

RT @ShorterLab: Identification of a covert evolutionary pathway between two protein folds: https://t.co/nN5LMzWr0M

Jun 1, 2023 · 5 shares · 316 followers View post →

MarkQuarter

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RT @ShorterLab: Identification of a covert evolutionary pathway between two protein folds: https://t.co/nN5LMzWr0M

Jun 1, 2023 · 5 shares · 1,606 followers View post →

ShorterLab

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Identification of a covert evolutionary pathway between two protein folds: https://t.co/nN5LMzWr0M

Jun 1, 2023 · 17 likes · 5 shares · 12,044 followers View post →

QMA0000

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RT @biorxiv_bioinfo: Identification of a covert evolutionary pathway between two protein folds https://t.co/f010AOuP2a #biorxiv_bioinfo

Dec 13, 2022 · 1 share · 310 followers View post →

bioRxiv Bioinfo

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Identification of a covert evolutionary pathway between two protein folds https://t.co/f010AOuP2a #biorxiv_bioinfo

Dec 12, 2022 · 1 like · 1 share · 18,073 followers View post →

bioRxiv

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Identification of a covert evolutionary pathway between two protein folds https://t.co/NdLVBDat9s #bioRxiv

Dec 12, 2022 · 136,953 followers View post →

Identification of a covert evolutionary pathway between two protein folds.

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Where it's discussed

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Abstract in brief

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All mentions

Uncovering Hidden Evolutionary Transitions Between Protein Folds