PubHawk
June 2023 PMID 37267950

Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity.

Mansi Arora, Justin Moser, Timothy E Hoffman, Lotte P Watts, Mingwei Min, Monica Musteanu, Yao Rong, C Ryland Ill, Varuna Nangia, Jordan Schneider, Manuel Sanclemente, John Lapek, Lisa Nguyen, Sherry Niessen, Stephen Dann

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Mentions

61
Peak: 24 in Jun 2023
across 4 sources since Jun 2023

Extended reach

320,589
potential audience

Total likes

79

Video views

75

Mentions per month

Jun 2023 – Feb 2024

Where it's discussed

  • X / Twitter27 posts
  • News27 articles
  • Blogs4 articles
  • YouTube3 videos

AI synopsis

What people are saying

The collective discussions reflect strong interest and engagement through mentions of specific mechanisms like CDK4/6 activity restoring cell proliferation and the potential for combination therapies, using language such as 'promising' and 'resistance,' which underscores the significance of the research. The tone ranges from informative to hopeful, indicating that the publication is considered impactful for advancing cancer treatment strategies.

AgreementModerate agreement

Most discussions acknowledge the significance of the findings, especially highlighting the challenge of cancer cell adaptation and the potential for combination therapies.

InterestHigh interest

Posts show high interest, with many emphasizing the promising implications for resistant cancers and the detailed mechanisms involved.

EngagementHigh engagement

There is deep engagement, as evidenced by references to molecular details like CDK4/6 activity, Rb1 phosphorylation, and the implications for treatment strategies.

ImpactModerate impact

The discussions suggest that these findings could influence future research and treatment approaches, but the overall impact remains optimistic rather than transformative.

Abstract in brief

  • CDK2 is a key enzyme in the cell cycle that, when hyperactivated in cancers, presents a potential target for new treatments.
  • Research shows that inhibiting CDK2 causes a quick drop in its activity, but cancer cells can adapt and restore its activity within hours, partly due to the compensatory effects of CDK4/6.
  • Findings suggest that using inhibitors for both CDK2 and CDK4/6 together may be necessary to effectively prevent cancer cells from adapting and resisting treatment.
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Top posts

Most liked on X and Bluesky
Cell
@CellCellPress · X

Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 2, 2023 · 70 likes · 21 shares · 262,879 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/uoq9INpxja

Jun 15, 2023 · 6 likes · 18,115 followers View post →
平賀信一朗 @ Aberdeen;
@shiraga0516 · X

Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/TNacC14FRc

Jun 1, 2023 · 1 like · 1,946 followers View post →
Rana Gbyli
@Rana_Gbyli · X

Jul 6, 2023 · 1 like · 1 share · 1,580 followers View post →
Creative Bioarray
@CreaBioarray · X

Study highlights promising drug combination for treating resistant breast cancer https://t.co/0dwf7rzPqY https://t.co/feTHInTFMl

Jun 20, 2023 · 1 like · 514 followers View post →
Dr Imran Sheikh
@DrImranSheikh · X

Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/f3I6Xmn1j0 https://t.co/MAGT7NoPut

Jun 3, 2023 · 24,220 followers View post →

All mentions

Yao Rong
@yao_rong5 · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Dec 11, 2023 · 21 shares · 111 followers View post →
Spencer Lab
@Spencer__Lab · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Aug 9, 2023 · 21 shares · 17 followers View post →
Rana Gbyli
@Rana_Gbyli · X

Jul 6, 2023 · 1 like · 1 share · 1,580 followers View post →
MedChemExpress
@MedChemExpress · X

#Cell: #CDK4/6 activity backstops inhibition of #CDK2 and sustains the proliferative program by maintaining Rb1 hyperphosphorylation, active #E2F transcription, and cyclin A2 expression, enabling re-activation of CDK2 in the presence of drug. https://t.co/nX2dEKlnTY #cancer https://t.co/D1OuCY8VBw

Jun 20, 2023 · 472 followers View post →
Creative Bioarray
@CreaBioarray · X

Study highlights promising drug combination for treating resistant breast cancer https://t.co/0dwf7rzPqY https://t.co/feTHInTFMl

Jun 20, 2023 · 1 like · 514 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/uoq9INpxja

Jun 15, 2023 · 6 likes · 18,115 followers View post →
MedChemExpress
@MedChemExpress · X

#Cell: CDK2 is a core cell-cycle kinase that #phosphorylates many substrates to drive progression through the cell cycle. Upon #CDK2 inhibition, cells exhibit a rapid loss of substrate phosphorylation that rebounds within several hours. #Cancer https://t.co/nX2dEKlnTY https://t.co/etDPNQwtos

Jun 7, 2023 · 472 followers View post →
Conscious Tone
@ToneConscious · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 6, 2023 · 21 shares · 54 followers View post →
BuchtovaLab
@MarcelaBuchtova · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 5, 2023 · 21 shares · 523 followers View post →
Sofi ҉
@sofivear · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 3, 2023 · 21 shares · 60 followers View post →
Dr Imran Sheikh
@DrImranSheikh · X

Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/f3I6Xmn1j0 https://t.co/MAGT7NoPut

Jun 3, 2023 · 24,220 followers View post →
Hana Sedlackova
@HanaSedlackova1 · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 3, 2023 · 21 shares · 883 followers View post →
Kejia Li
@KeJia93_Li · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 3, 2023 · 21 shares · 36 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 3, 2023 · 21 shares · 573 followers View post →
Szu Shuo Lee
@ShuoSzu · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 3, 2023 · 21 shares · 156 followers View post →
Dr. Fawaz Alzaid
@DrFAlzaid · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 2, 2023 · 21 shares · 1,698 followers View post →
AnonRere
@AnonRere · X

Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/psXysQI9Ql

Jun 2, 2023 · 2,224 followers View post →
Guillermo de Cárcer
@GdC_CCCB_lab · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 2, 2023 · 21 shares · 1,466 followers View post →
Lotte Watts
@LotteWatts · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 2, 2023 · 21 shares · 148 followers View post →
Terry Hoover
@TerryHo70841353 · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 2, 2023 · 21 shares · 403 followers View post →
Ganesh Kumar Barik, PhD
@itsme_gkb · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 2, 2023 · 21 shares · 308 followers View post →
BeABa
@infoalcupom · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 2, 2023 · 21 shares · 45 followers View post →
Le Tran Phuc Khoa
@LeTranPhucKhoa1 · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 2, 2023 · 21 shares · 264 followers View post →
Vidisha Tripathi
@VidishaTC · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 2, 2023 · 21 shares · 74 followers View post →
Dieter
@Wuhle · X

RT @CellCellPress: Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 2, 2023 · 21 shares · 473 followers View post →
Cell
@CellCellPress · X

Now online! Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/jyJRfJ9sJZ

Jun 2, 2023 · 70 likes · 21 shares · 262,879 followers View post →
平賀信一朗 @ Aberdeen;
@shiraga0516 · X

Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity https://t.co/TNacC14FRc

Jun 1, 2023 · 1 like · 1,946 followers View post →