Nat Commun June 2023 PMID 37280206

Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors.

Julien Schmidt, Johanna Chiffelle, Marta A S Perez, Morgane Magnin, Sara Bobisse, Marion Arnaud, Raphael Genolet, Julien Cesbron, David Barras, Blanca Navarro Rodrigo, Fabrizio Benedetti, Alexandra Michel, Lise Queiroz, Petra Baumgaertner, Philippe Guillaume

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Peak: 10 in Jun 2023

across 3 sources since Jun 2023

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Jun 2023 – Sep 2023

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What people are saying

Discussions repeatedly affirm the significance of high-avidity neoantigen-specific CD8 T cells for tumor elimination, with phrases like 'game-changer' and 'potential breakthrough' indicating a positive and impactful perception. The consistent sharing of the article titles and supportive tone reflect high interest and engagement, with some posts mentioning the promise of personalized cancer immunotherapy based on these findings.

AgreementStrong agreement

Most discussions express strong support and agreement with the findings, emphasizing the importance of high avidity T cells in cancer treatment.

InterestHigh interest

The posts demonstrate high interest, highlighting the potential therapeutic implications and the scientific advancements presented.

EngagementModerate engagement

While many posts show active sharing and endorsement, some are brief, indicating solid interest but less in-depth analysis from all commentators.

ImpactHigh impact

The widespread excitement and repeated emphasis on the potential for improved cancer therapies suggest a high perceived impact.

Abstract in brief

High-avidity neoantigen-specific CD8 T cells are more effective at residing in and eliminating tumors, making them key players in cancer immunotherapy.
T cells from tumors tend to have stronger functional and structural avidity than those from blood, with neoantigen-specific T cells showing the highest avidity and tumor preference.
An in silico model based on TCR properties can predict high avidity T cells, which are enriched in tumors, suggesting that targeting these potent T cells can improve personalized cancer treatments.

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High-Avidity Neoantigen-Specific CD8 T Cells and Tumor Elimination

STEM RTCL TV · Sep 27, 2023 87 views

Dr Chris Thorpe

@drchristhorpe · X

RT @Ox_T_Cell_ASN: Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors | Nature Comm…

Jun 8, 2023 · 2 shares · 613 followers View post →

Lum Lab

@lum_lab · X

RT @mjwsim: Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors https://t.co/5faSq9…

Jun 8, 2023 · 3 shares · 1,209 followers View post →

OxASN: The Oxford Antigen Specificity Network

@Ox_T_Cell_ASN · X

Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors | Nature Communications https://t.co/qSgVifus0Z

Jun 8, 2023 · 10 likes · 2 shares · 348 followers View post →

hashem

@hashemkoohy · X

Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors | Nature Communications https://t.co/0BkQDAhZmL

Jun 8, 2023 · 761 followers View post →

Jin Seok (Andy) Lee

@iam_js_lee · X

RT @mjwsim: Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors https://t.co/5faSq9…

Jun 7, 2023 · 3 shares · 176 followers View post →

Ana Calber

@amcalber · X

RT @mjwsim: Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors https://t.co/5faSq9…

Jun 7, 2023 · 3 shares · 2,280 followers View post →

Malcolm Sim

@mjwsim · X

Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors https://t.co/5faSq9JPvw

Jun 7, 2023 · 18 likes · 3 shares · 1,816 followers View post →

minnlab_litbot

@MLitbot · X

Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors https://t.co/5kaaNBnwNK https://t.co/Ep3EAQAW37

Jun 7, 2023 · 72 followers View post →

The Innovation | Medicine

@Innov_Medicine · X

RT @Aiims1742: Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors https://t.co/nsmv…

Jun 6, 2023 · 1 share · 253,979 followers View post →

Anirban Maitra

@Aiims1742 · X

Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors https://t.co/nsmvEGgeMk

Jun 6, 2023 · 4 likes · 1 share · 31,240 followers View post →

Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors.

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High-Avidity Neoantigen-Specific CD8 T Cells and Tumor Elimination