Nat Neurosci June 2023 PMID 37280397

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB.

Rafael Moliner, Mykhailo Girych, Cecilia A Brunello, Vera Kovaleva, Caroline Biojone, Giray Enkavi, Lina Antenucci, Erik F Kot, Sergey A Goncharuk, Katja Kaurinkoski, Mirjami Kuutti, Senem M Fred, Lauri V Elsilä, Sven Sakson, Cecilia Cannarozzo

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Mentions

160
Peak: 54 in Jun 2023
across 7 sources since Jun 2023

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AI synopsis

What people are saying

Several discussions emphasize the disconnect between the beneficial properties of psychedelics and their hallucinogenic effects, referring to this differentiation as crucial for potential antidepressant applications. Phrases such as 'fascinating study' and 'interesting idea' reflect excitement and engagement, while requests for further discussions about the research highlight the community's interest in deepening their understanding.

AgreementModerate agreement

Most discussions express a moderate level of agreement with the conclusions of the publication, suggesting that psychedelics have significant potential for promoting neuroplasticity.

InterestHigh interest

The discussions show strong curiosity regarding the findings and implications of the research, reflecting a high level of engagement with the topic.

EngagementModerate engagement

While the conversations do cover the implications and methodology of the study, they tend to lean more towards sharing the publication rather than in-depth analysis.

ImpactHigh impact

Many individuals believe the findings of this research could have a substantial influence on future antidepressant development and understanding of psychedelics.

Abstract in brief

  • Psychedelics like LSD and psilocin show stronger binding to the TrkB receptor than traditional antidepressants, leading to quick and lasting antidepressant effects.
  • Their effects on neuroplasticity and mood improvements in mice are linked to TrkB signaling and promote brain-derived neurotrophic factor (BDNF) activity, but don’t rely on serotonin 2A receptor activation.
  • This research suggests that developing new antidepressants that enhance TrkB activity without affecting serotonin pathways could achieve the mood-lifting benefits of psychedelics while avoiding hallucinations.

Top posts

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Rafael Moliner
@RafaelMoliner · X

Our paper “Psychedelics promote plasticity by directly binding to BDNF receptor TrkB” was published in open access @natureneuroscience. Cheers to all! https://t.co/AlxH9zDLaz 15/

Jun 5, 2023 · 49 likes · 12 shares · 233 followers View post →
Mark Oldham
@MarkOldhamMD · X

Fascinating study suggests that the antidepressant effects of LSD & psilocybin are independent of 5-HT2a activity. Link: https://t.co/ZPVTkk4YcP https://t.co/LSPOx9NLqY

Jun 6, 2023 · 43 likes · 10 shares · 2,187 followers View post →
Agingdoc
@agingdoc1 · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB @RafaelMoliner @p_casarotto @UH_Neuro @HkiBrainMind & @castren_eero | @NatureNeuro https://t.co/E3m2or8x9i https://t.co/et4Jc0TJa9

Jun 6, 2023 · 10 likes · 3 shares · 41,345 followers View post →
デカめの犬
@Lotus_Solus · X

サイケデリクスの強力な抗うつ効果の詳細なメカニズムがついに明らかになったか? Psychedelics promote plasticity by directly binding to BDNF receptor TrkB https://t.co/ap1tjUccap

Jun 8, 2023 · 9 likes · 1,760 followers View post →
BenLewisMD
@BenLewisMD · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB | Nature Neuroscience https://t.co/7chzKpsOZA

Jun 5, 2023 · 4 likes · 1 share · 154 followers View post →
Seasky
@Marcel68151734 · X

@analog_ashley https://t.co/KskatGAOCl

Aug 14, 2023 · 4 likes · 10 followers View post →

All mentions

ghostpen
@gh0stpen · X

@hanna_pssd @NTFabiano not once said ssri‘s was referring to this study: https://t.co/vdXWuLUZJ6

Jun 16, 2025 · 375 followers View post →
The Science Basement Podcast
@SciBasementPod · X

Find Rafael's publication here: Psychedelics promote plasticity by directly binding to BDNF receptor TrkB | Nature Neuroscience [https://t.co/knW3vDXpF6]

Nov 20, 2024 · 103 followers View post →
Awaken The “I AM” | r/microdosing | Mush Love
@LiveInMushLove · X

RT @Neurons2Nirvana: I just posted "Abstract* | #Psychedelics promote #plasticity by directly #binding to #BDNF #receptor #TrkB | Nature #N…

Apr 27, 2024 · 1 share · 727 followers View post →
The vOICe vision BCI
@seeingwithsound · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB https://t.co/3vCqlrVOVP "plasticity-promoting effects of psychedelics may be dissociable from their hallucinogenic effects"

Sep 12, 2023 · 3,731 followers View post →
The vOICe vision BCI
@seeingwithsound.bsky.social · Bluesky

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB www.nature.com/articles/s41... "plasticity-promoting effects of psychedelics may be dissociable from their hallucinogenic effects"

Sep 12, 2023 View post →
alhrab
@alhrab · X

@etoEMIdato https://t.co/8qnjGFcnys

Sep 9, 2023 · 470 followers View post →
io
@io_1337 · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB | Nature Neuroscience https://t.co/2kRXN73m4p

Aug 31, 2023 · 2,778 followers View post →
Seasky
@Marcel68151734 · X

@analog_ashley https://t.co/KskatGAOCl

Aug 14, 2023 · 4 likes · 10 followers View post →
Researching the Brain
@Brain_Database · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB #brain https://t.co/9HS0uXUbqF

Jul 6, 2023 · 1 like · 1,038 followers View post →
LINK
@dioreipluc79035 · X

RT @cg_dr: Psychedelics promote plasticity by directly binding to BDNF receptor TrkB | Nature Neuroscience https://t.co/w7Rm4V2ift

Jun 18, 2023 · 1 share View post →
Brendan Leier
@BrendanLeier · X

@alieninsect @KONCRETE hey Andrew are you planning on discussing this new BDNF paper? https://t.co/wjBF6GhD0z please consider this a request if that's helpful! ;)

Jun 14, 2023 · 36 followers View post →
/r/Neuroscience
@neuroreddit · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB - Nature Neuroscience https://t.co/6y2uls7Gsd

Jun 14, 2023 · 6 followers View post →
Blossom
@blossomact · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB https://t.co/yGupdNzVfV https://t.co/d5OjRLYLNB

Jun 14, 2023 · 1 like · 3,363 followers View post →
Elena Lopez
@ela979905 · X

RT @MASogorb: ¿Separar los efectos positivos de los negativos en drogas psicodélicas para crear antidepresivos? https://t.co/ebj51ff4zd Más…

Jun 13, 2023 · 1 share · 194 followers View post →
HN Bot
@TechTweetBot · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB https://t.co/TcAoN5Rb10

Jun 10, 2023 · 259 followers View post →
Miguel Ángel Sogorb
@MASogorb · X

¿Separar los efectos positivos de los negativos en drogas psicodélicas para crear antidepresivos? https://t.co/ebj51ff4zd Más información: Psychedelics promote plasticity by directly binding to BDNF receptor TrkB https://t.co/XVlShPO8rO

Jun 10, 2023 · 3 likes · 1 share · 158 followers View post →
Dr Catherine Gray
@cg_dr · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB | Nature Neuroscience https://t.co/w7Rm4V2ift

Jun 9, 2023 · 1 like · 1 share · 627 followers View post →
デカめの犬
@Lotus_Solus · X

サイケデリクスの強力な抗うつ効果の詳細なメカニズムがついに明らかになったか? Psychedelics promote plasticity by directly binding to BDNF receptor TrkB https://t.co/ap1tjUccap

Jun 8, 2023 · 9 likes · 1,760 followers View post →
The vOICe vision BCI
@seeingwithsound · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB https://t.co/3vCqlrVOVP "antidepressant and #plasticity-promoting effects of #psychedelics may be dissociable from their hallucinogenic effects"; #neuroplasticity

Jun 7, 2023 · 3,731 followers View post →
GLASS_PhD
@joybeingfree99 · X

RT @agingdoc1: Psychedelics promote plasticity by directly binding to BDNF receptor TrkB @RafaelMoliner @p_casarotto @UH_Neuro @HkiBrainM…

Jun 7, 2023 · 3 shares · 6,637 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Psychedelics promote plasticity by directly binding to BDNF receptor TrkB @RafaelMoliner @p_casarotto @UH_Neuro @HkiBrainM…

Jun 7, 2023 · 3 shares · 134 followers View post →
Mind Escape Podcast
@MikeEscape · X

RT @APRAresearch: Psychedelics promote plasticity by directly binding to BDNF receptor TrkB https://t.co/J4ZZEevdKZ

Jun 7, 2023 · 1 share · 4,078 followers View post →
Eduardo (Top 0.3% of Eduardos)
@eedsterr · X

RT @MarkOldhamMD: Fascinating study suggests that the antidepressant effects of LSD & psilocybin are independent of 5-HT2a activity. Link:…

Jun 7, 2023 · 10 shares · 209 followers View post →
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB https://t.co/J4ZZEevdKZ

Jun 7, 2023 · 2 likes · 1 share · 4,013 followers View post →
Toshiharu Kamishikiryo
@k5105880 · X

RT @MarkOldhamMD: Fascinating study suggests that the antidepressant effects of LSD & psilocybin are independent of 5-HT2a activity. Link:…

Jun 7, 2023 · 10 shares · 58 followers View post →
Daniel Thomson
@djthomson · X

RT @MarkOldhamMD: Fascinating study suggests that the antidepressant effects of LSD & psilocybin are independent of 5-HT2a activity. Link:…

Jun 7, 2023 · 10 shares · 2,073 followers View post →
Yuji Marutani Planning Director
@YujiMarutani · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB https://t.co/nUhBxvTwKl

Jun 7, 2023 · 1,577 followers View post →
Julianchis Rios
@JulianchisRios · X

RT @MarkOldhamMD: Fascinating study suggests that the antidepressant effects of LSD & psilocybin are independent of 5-HT2a activity. Link:…

Jun 7, 2023 · 10 shares · 98 followers View post →
José E Oliva
@Jeob18 · X

RT @MarkOldhamMD: Fascinating study suggests that the antidepressant effects of LSD & psilocybin are independent of 5-HT2a activity. Link:…

Jun 7, 2023 · 10 shares · 209 followers View post →
Andrea Roland-Rodríguez
@vertosomnium · X

RT @MarkOldhamMD: Fascinating study suggests that the antidepressant effects of LSD & psilocybin are independent of 5-HT2a activity. Link:…

Jun 7, 2023 · 10 shares · 380 followers View post →
JRPalafox
@Palafox_Cuervo · X

RT @MarkOldhamMD: Fascinating study suggests that the antidepressant effects of LSD & psilocybin are independent of 5-HT2a activity. Link:…

Jun 7, 2023 · 10 shares · 139 followers View post →
Angelica Miriam Yañez Zubieta
@mompsiqstylist · X

RT @MarkOldhamMD: Fascinating study suggests that the antidepressant effects of LSD & psilocybin are independent of 5-HT2a activity. Link:…

Jun 7, 2023 · 10 shares · 114 followers View post →
Jesus Ramirez-Bermudez
@JRBneuropsiq · X

RT @MarkOldhamMD: Fascinating study suggests that the antidepressant effects of LSD & psilocybin are independent of 5-HT2a activity. Link:…

Jun 7, 2023 · 10 shares · 31,246 followers View post →
Edelic Center for Ethnobotanical Services
@EC4ES · X

LSD & psilocin directly bind to TrkB w/ affinities 1,000-fold higher than... other antidepressants. TrkB, the receptor for BDNF (brain-derived neurotrophic factor)... new growth in both baby & mature neurons... fast & persistent antidepressant effects... https://t.co/Ng56cjx3Ld https://t.co/ieQJ93BFDX

Jun 6, 2023 · 1,259 followers View post →
Rifat S. İLHAN
@rifatilhan · X

RT @MarkOldhamMD: Fascinating study suggests that the antidepressant effects of LSD & psilocybin are independent of 5-HT2a activity. Link:…

Jun 6, 2023 · 10 shares · 716 followers View post →
Mark Oldham
@MarkOldhamMD · X

Fascinating study suggests that the antidepressant effects of LSD & psilocybin are independent of 5-HT2a activity. Link: https://t.co/ZPVTkk4YcP https://t.co/LSPOx9NLqY

Jun 6, 2023 · 43 likes · 10 shares · 2,187 followers View post →
Agingdoc
@agingdoc1 · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB @RafaelMoliner @p_casarotto @UH_Neuro @HkiBrainMind & @castren_eero | @NatureNeuro https://t.co/E3m2or8x9i https://t.co/et4Jc0TJa9

Jun 6, 2023 · 10 likes · 3 shares · 41,345 followers View post →
Meg Davis
@BrainsRus · X

I suspect that this is going to send me down a rabbit hole of references. Interesting idea. Psychedelics promote plasticity by directly binding to BDNF receptor TrkB | Nature Neuroscience https://t.co/3YAOEACP9g

Jun 6, 2023 · 1,057 followers View post →
LAGC-PsychiatricGenetics
@LAGCPsychGene · X

RT @daforerog: Psychedelics promote plasticity by directly binding to BDNF receptor TrkB https://t.co/ClyNhtBri0

Jun 6, 2023 · 2 shares · 269 followers View post →
Diego Forero MD, PhD
@daforerog · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB https://t.co/ClyNhtBri0

Jun 6, 2023 · 1 like · 2 shares · 1,597 followers View post →
Piracetam.Net
@PiracetamNET · X

I just posted "Psychedelics promote plasticity by directly binding to BDNF receptor TrkB" on Reddit https://t.co/ZGEmhCSvsJ

Jun 6, 2023 · 78 followers View post →
Keri Martinowich
@martinowk · X

RT @RafaelMoliner: Our paper “Psychedelics promote plasticity by directly binding to BDNF receptor TrkB” was published in open access @natu…

Jun 6, 2023 · 12 shares · 2,946 followers View post →
AbimaelGH
@AbimaelGH · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB | Nature Neuroscience

Jun 5, 2023 · 1 like · 163 followers View post →
Leah Mayo
@MayoOnTheBrain · X

RT @RafaelMoliner: Our paper “Psychedelics promote plasticity by directly binding to BDNF receptor TrkB” was published in open access @natu…

Jun 5, 2023 · 12 shares · 2,836 followers View post →
On the Jol
@Onthejol · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB | Nature Neuroscience https://t.co/XwGUJW6FBn

Jun 5, 2023 · 27 followers View post →
Narkhyun Bae
@ghostbnh · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB https://t.co/5vCbcEe3kX

Jun 5, 2023 · 1 like · 523 followers View post →
Carolyn Rodriguez
@CRodriguezMDPhD · X

RT @RafaelMoliner: Our paper “Psychedelics promote plasticity by directly binding to BDNF receptor TrkB” was published in open access @natu…

Jun 5, 2023 · 12 shares · 4,316 followers View post →
Awaken The “I AM” | r/microdosing | Mush Love
@LiveInMushLove · X

I just posted "Abstract* | #Psychedelics promote #plasticity by directly #binding to #BDNF #receptor #TrkB | Nature #Neuroscience (@NatureNeuro) [Jun 2023] #LSD #psilocin #fluoxetine #ketamine #Neuroplasticity" on Reddit https://t.co/cuDSI5lwjP

Jun 5, 2023 · 1 share · 727 followers View post →
Awaken The “I AM” | r/microdosing | Mush Love
@LiveInMushLove · X

@ferenstein @BellevueDoc ICYMI: #Psychedelics promote #plasticity by directly binding to #BDNF receptor #TrkB: https://t.co/NgXn3PTDmd

Jun 5, 2023 · 1 like · 727 followers View post →
p0te
@laplandweed · X

RT @RafaelMoliner: Our paper “Psychedelics promote plasticity by directly binding to BDNF receptor TrkB” was published in open access @natu…

Jun 5, 2023 · 12 shares · 419 followers View post →
albert grabb
@radiolating · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB | Nature Neuroscience https://t.co/7EQlO78TAC

Jun 5, 2023 · 3 likes · 69 followers View post →
Katja K
@katjaviivi · X

RT @RafaelMoliner: Our paper “Psychedelics promote plasticity by directly binding to BDNF receptor TrkB” was published in open access @natu…

Jun 5, 2023 · 12 shares · 442 followers View post →
Varjosalo_Lab
@Varjosalo_Lab · X

RT @RafaelMoliner: Our paper “Psychedelics promote plasticity by directly binding to BDNF receptor TrkB” was published in open access @natu…

Jun 5, 2023 · 12 shares · 719 followers View post →
christopher gregg
@GreggNeuroLab · X

RT @BenLewisMD: Psychedelics promote plasticity by directly binding to BDNF receptor TrkB | Nature Neuroscience https://t.co/7chzKpsOZA

Jun 5, 2023 · 1 share · 953 followers View post →
Nazim Kourdougli
@n_kourdougli · X

RT @RafaelMoliner: Our paper “Psychedelics promote plasticity by directly binding to BDNF receptor TrkB” was published in open access @natu…

Jun 5, 2023 · 12 shares · 199 followers View post →
Eero Castren
@castren_eero · X

RT @RafaelMoliner: Our paper “Psychedelics promote plasticity by directly binding to BDNF receptor TrkB” was published in open access @natu…

Jun 5, 2023 · 12 shares · 781 followers View post →
BenLewisMD
@BenLewisMD · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB | Nature Neuroscience https://t.co/7chzKpsOZA

Jun 5, 2023 · 4 likes · 1 share · 154 followers View post →
BrainSights iOS App
@BrainSightsApp · X

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB - Nature Neuroscience via BrainSights for iOS https://t.co/BkRRfrdHGy

Jun 5, 2023 · 312 followers View post →
Mychael Lourenco
@mvlourenco · X

RT @RafaelMoliner: Our paper “Psychedelics promote plasticity by directly binding to BDNF receptor TrkB” was published in open access @natu…

Jun 5, 2023 · 12 shares · 3,020 followers View post →
Anaïs Virenque
@Anais_Virenque · X

RT @RafaelMoliner: Our paper “Psychedelics promote plasticity by directly binding to BDNF receptor TrkB” was published in open access @natu…

Jun 5, 2023 · 12 shares · 94 followers View post →
Seasky
@Marcel68151734 · X

RT @RafaelMoliner: Our paper “Psychedelics promote plasticity by directly binding to BDNF receptor TrkB” was published in open access @natu…

Jun 5, 2023 · 12 shares · 10 followers View post →
Rafael Moliner
@RafaelMoliner · X

Our paper “Psychedelics promote plasticity by directly binding to BDNF receptor TrkB” was published in open access @natureneuroscience. Cheers to all! https://t.co/AlxH9zDLaz 15/

Jun 5, 2023 · 49 likes · 12 shares · 233 followers View post →