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J Biomed Sci June 2023 PMID 37287024

Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143/145.

Henry Wade, Kaichao Pan, Qihua Duan, Szczepan Kaluzny, Ekta Pandey, Linda Fatumoju, Viswanathan Saraswathi, Rongxue Wu, Edward N Harris, Qiaozhu Su

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Mentions

9
Peak: 7 in Jun 2023
across 2 sources since Jun 2023

Extended reach

28,814
potential audience

Total likes

11

Video views

170

Mentions per month

Jun 2023 – Sep 2023

Where it's discussed

  • X / Twitter8 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions reflect a balanced recognition of the article's findings, with mentions of the bacterium's role in reducing inflammation and support for epithelial healing—highlighted by phrases like 'key link' and 'potentials for therapies'. The tone varies from technical to hopeful, illustrating an interest in both scientific detail and future applications.

AgreementModerate agreement

Most discussants acknowledge the significance of the findings, highlighting the therapeutic potential of A. muciniphila and its proteins in gut health.

InterestModerate interest

The discussions show moderate interest, with attendees engaged in understanding the mechanisms and implications of the research.

EngagementModerate engagement

Comments include references to specific pathways like CREBH and miR-143/145, indicating a reasonable level of detailed engagement.

ImpactModerate impact

Some posts suggest that this research could be influential in developing gut inflammation therapies, reflecting perceived moderate impact.

Abstract in brief

  • A. The study explores how Akkermansia muciniphila, a beneficial gut bacterium, helps improve intestinal barrier function and promotes healing by regulating the transcription factor CREBH and microRNA miR143-145.
  • B. Increased presence of A. muciniphila boosts CREBH expression, reduces gut stress and inflammation, and supports epithelial cell regeneration, while deficiency in CREBH worsens gut permeability and inflammation.
  • C. The research also identifies that a specific protein from A. muciniphila, Amuc1100, may play a role in these beneficial effects, highlighting potential targets for therapies to treat gut inflammation and promote healing.
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Top posts

Most liked on X and Bluesky
Phenomics
@Phenomics_J · X

Wade et al. discovered a key link between Akkermansia muciniphila and intestinal cAMP-responsive element-binding protein H (CREBH) in gut health that yields several novel findings. #Phenomics #Akkermansiamuciniphila # From Journal of biomedical science: https://t.co/Kcua90EmhH https://t.co/vGEMxrOMWI

Jun 12, 2023 · 7 likes · 3 shares · 1,528 followers View post →
Microbiome Articles
@microbe_article · X

Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound hea... - Wade H et al. - https://t.co/w5aoMIShSh #microbiome

Jun 8, 2023 · 2 likes · 7,153 followers View post →
ppierodds
@ppierodds · X

#Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143/145 | Journal of Biomedical Science | Full Text https://t.co/kSm8qcfoY4

Jul 1, 2023 · 17,882 followers View post →
Europe PMC articles
@EuropePMC · X

New from #TheBHF https://t.co/vihmwJXCTB Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143/145.

Jun 10, 2023 · 1,552 followers View post →
Jiajia Chen, PhD, PMP
@JiajiaChen15 · X

RT @Phenomics_J: Wade et al. discovered a key link between Akkermansia muciniphila and intestinal cAMP-responsive element-binding protein H…

Jun 12, 2023 · 3 shares · 381 followers View post →
Biofactoid
@biofactoid · X

Read the paper: https://t.co/ZNHVMo18s6

Jun 23, 2023 · 92 followers View post →

All mentions

ppierodds
@ppierodds · X

#Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143/145 | Journal of Biomedical Science | Full Text https://t.co/kSm8qcfoY4

Jul 1, 2023 · 17,882 followers View post →
Biofactoid
@biofactoid · X

Read the paper: https://t.co/ZNHVMo18s6

Jun 23, 2023 · 92 followers View post →
Wenzhu Zhai
@zhaiwenzhu · X

RT @Phenomics_J: Wade et al. discovered a key link between Akkermansia muciniphila and intestinal cAMP-responsive element-binding protein H…

Jun 13, 2023 · 3 shares · 26 followers View post →
Yidan Gao
@YidanGao1544591 · X

RT @Phenomics_J: Wade et al. discovered a key link between Akkermansia muciniphila and intestinal cAMP-responsive element-binding protein H…

Jun 12, 2023 · 3 shares · 7 followers View post →
Jiajia Chen, PhD, PMP
@JiajiaChen15 · X

RT @Phenomics_J: Wade et al. discovered a key link between Akkermansia muciniphila and intestinal cAMP-responsive element-binding protein H…

Jun 12, 2023 · 3 shares · 381 followers View post →
Phenomics
@Phenomics_J · X

Wade et al. discovered a key link between Akkermansia muciniphila and intestinal cAMP-responsive element-binding protein H (CREBH) in gut health that yields several novel findings. #Phenomics #Akkermansiamuciniphila # From Journal of biomedical science: https://t.co/Kcua90EmhH https://t.co/vGEMxrOMWI

Jun 12, 2023 · 7 likes · 3 shares · 1,528 followers View post →
Europe PMC articles
@EuropePMC · X

New from #TheBHF https://t.co/vihmwJXCTB Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143/145.

Jun 10, 2023 · 1,552 followers View post →
Microbiome Articles
@microbe_article · X

Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound hea... - Wade H et al. - https://t.co/w5aoMIShSh #microbiome

Jun 8, 2023 · 2 likes · 7,153 followers View post →