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Nat Commun June 2023 PMID 37291094

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.

Xinhong Chen, Damien A Wolfe, Dhanesh Sivadasan Bindu, Mengying Zhang, Naz Taskin, David Goertsen, Timothy F Shay, Erin E Sullivan, Sheng-Fu Huang, Sripriya Ravindra Kumar, Cynthia M Arokiaraj, Viktor M Plattner, Lillian J Campos, John K Mich, Deja Monet

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Mentions

49
Peak: 34 in Jan 2023
across 4 sources since Jan 2023

Extended reach

196,718
potential audience

Total likes

203

Video views

17

Mentions per month

Jan 2023 – Sep 2023

Where it's discussed

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  • YouTube1 videos

AI synopsis

What people are saying

Several posts express excitement about the innovative gene delivery techniques, using phrases like 'very excited' and emphasizing the broad species applicability, which underscores their high interest. The tone reflects optimism about the method's potential to revolutionize treatments involving brain vasculature, with users engaging deeply by discussing technical aspects and future implications, indicating both high interest and perceived impact.

AgreementModerate agreement

Most discussions recognize the significance of the research, with comments highlighting its innovative approach to gene delivery and potential for broad applications, indicating moderate to strong agreement on its importance.

InterestHigh interest

Posts show high curiosity and engagement, with expressions like 'very excited' and mentions of new work and potential breakthroughs that suggest the topic resonates well with those following this field.

EngagementModerate engagement

Several discussions reference specific aspects of the research, such as the targeting of brain vasculature and implications for neurological treatments, demonstrating a deeper interest and understanding.

ImpactHigh impact

Many comments emphasize the potential transformative impact, describing the study as 'game-changing' and highlighting its broad applicability across species, which signals high perceived significance.

Abstract in brief

  • Researchers developed special AAV9 virus vectors that target and deliver genes specifically to brain blood vessel cells (endothelial cells) in rodents and perform well across different species, including primates and human brain tissue.
  • These modified viruses can switch between different AAV serotypes, allowing flexible and repeated gene delivery strategies in mice.
  • By using these vectors, scientists successfully transformed the brain's blood vessels into tools that produce specific proteins, such as Sparcl1, which helped restore synaptic functions in genetically modified mice with neural deficits.]
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Xinhong Chen
@xinhong_chen · X

Very excited to share my new work in @VivianGradinaru lab at the start of new year of

Jan 22, 2023 · 196 likes · 34 shares · 528 followers View post →
ShorterLab
@ShorterLab · X

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates: https://t.co/mFIRoIajx0

Jun 8, 2023 · 2 likes · 1 share · 12,043 followers View post →
PromisingPreprints
@PromPreprint · X

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates https://t.co/M9yYfN4yCN

Jan 23, 2023 · 2 likes · 3,309 followers View post →
UCSD Psychology
@UCSDPsychology · X

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates https://t.co/IKg45iTrfM https://t.co/klQGQTRaV9

Jun 9, 2023 · 1 like · 842 followers View post →
UCSD Psychology
@UCSDPsychology · X

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates https://t.co/YFK10VZ3gp https://t.co/V83SdbST75

Jun 15, 2023 · 1 like · 842 followers View post →
AAVpapers
@AAVpapers · X

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates https://t.co/YJSOWnWtHP https://t.co/274S54CWur

Jun 10, 2023 · 1 like · 147 followers View post →

All mentions

Anjali Kusumbe
@KusumbeLab · X

RT @ShorterLab: Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents an…

Jun 18, 2023 · 1 share · 2,054 followers View post →
UCSD Psychology
@UCSDPsychology · X

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates https://t.co/YFK10VZ3gp https://t.co/V83SdbST75

Jun 15, 2023 · 1 like · 842 followers View post →
UCL Discovery
@ucl_discovery · X

Open Access UCL Research: Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates https://t.co/7FItFXsygK

Jun 14, 2023 · 2,526 followers View post →
AAVpapers
@AAVpapers · X

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates https://t.co/YJSOWnWtHP https://t.co/274S54CWur

Jun 10, 2023 · 1 like · 147 followers View post →
UCSD Psychology
@UCSDPsychology · X

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates https://t.co/IKg45iTrfM https://t.co/klQGQTRaV9

Jun 9, 2023 · 1 like · 842 followers View post →
Phage Papers
@Phage_Papers · X

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates https://t.co/XaL66aiETf

Jun 9, 2023 · 647 followers View post →
Giorgio Seano
@GiorgioSeano · X

RT @xinhong_chen: Very excited to share my new work in @VivianGradinaru lab at the start of new year of

Jun 8, 2023 · 34 shares · 1,198 followers View post →
ShorterLab
@ShorterLab · X

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates: https://t.co/mFIRoIajx0

Jun 8, 2023 · 2 likes · 1 share · 12,043 followers View post →
PrimateDNA Papers
@PrimateDNA_Lit · X

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates https://t.co/DNQMStSjRk

Jan 30, 2023 · 53 followers View post →
Yueqiang Zhang
@JohnZha02385409 · X

RT @xinhong_chen: Very excited to share my new work in @VivianGradinaru lab at the start of new year of

Jan 29, 2023 · 34 shares · 59 followers View post →
Ariakas Enoreth
@Aenoreth · X

RT @xinhong_chen: Very excited to share my new work in @VivianGradinaru lab at the start of new year of

Jan 24, 2023 · 34 shares · 1,009 followers View post →
Sangjun Lee
@sleefos1 · X

RT @xinhong_chen: Very excited to share my new work in @VivianGradinaru lab at the start of new year of

Jan 23, 2023 · 34 shares · 72 followers View post →
PromisingPreprints
@PromPreprint · X

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates https://t.co/M9yYfN4yCN

Jan 23, 2023 · 2 likes · 3,309 followers View post →
Brian Dean
@bdean_ · X

RT @xinhong_chen: Very excited to share my new work in @VivianGradinaru lab at the start of new year of

Jan 23, 2023 · 34 shares · 562 followers View post →
Kai Chen
@kaichen_1990 · X

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Simon Waddington
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RT @xinhong_chen: Very excited to share my new work in @VivianGradinaru lab at the start of new year of

Jan 23, 2023 · 34 shares · 1,108 followers View post →
Siberian fox
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RT @xinhong_chen: Very excited to share my new work in @VivianGradinaru lab at the start of new year of

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Matt McAteer
@MatthewMcAteer0 · X

RT @xinhong_chen: Very excited to share my new work in @VivianGradinaru lab at the start of new year of

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Kenneth Loi
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RT @xinhong_chen: Very excited to share my new work in @VivianGradinaru lab at the start of new year of

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Tatz Ishimaru
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RT @xinhong_chen: Very excited to share my new work in @VivianGradinaru lab at the start of new year of

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Ankit Choudhury
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RT @xinhong_chen: Very excited to share my new work in @VivianGradinaru lab at the start of new year of

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Craig E Brown
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Ryan Cho
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Lili
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RT @xinhong_chen: Very excited to share my new work in @VivianGradinaru lab at the start of new year of

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Peiwei Chen
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Yu Zhao
@yu48693 · X

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XiaoZhe Ding
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Xinhong Chen
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Very excited to share my new work in @VivianGradinaru lab at the start of new year of

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bioRxiv Bioengineering
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Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates https://t.co/i8bcWxGnsm #biorxiv_bioE

Jan 13, 2023 · 206 followers View post →
bioRxiv
@biorxivpreprint · X

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