Nat Commun June 2023 PMID 37291246

Tumour mutations in long noncoding RNAs enhance cell fitness.

Roberta Esposito, Andrés Lanzós, Tina Uroda, Sunandini Ramnarayanan, Isabel Büchi, Taisia Polidori, Hugo Guillen-Ramirez, Ante Mihaljevic, Bernard Mefi Merlin, Lia Mela, Eugenio Zoni, Lusine Hovhannisyan, Finn McCluggage, Matúš Medo, Giulia Basile

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Peak: 5 in Jun 2023

across 3 sources since Jun 2023

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Jun 2023 – Sep 2023

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The discussions emphasize the importance of mutations in long noncoding RNAs for cancer progression, with references to specific genes like NEAT1 that increase tumor growth, and highlight the experimental evidence supporting these claims. The tone combines curiosity and respect for the research's implications, demonstrating a balanced recognition of its significance.

AgreementModerate agreement

Most comments seem to acknowledge the significance of the research, with some expressing support for the findings on how specific mutations in lncRNAs promote tumor growth.

InterestHigh interest

Discussions indicate a high level of curiosity, especially around the mechanisms by which mutations influence cancer cell fitness and the potential implications for therapy.

EngagementModerate engagement

Posts reference particular genes like NEAT1 and discuss experimental evidence, showing a moderate level of deep engagement with the research details.

ImpactHigh impact

The discussions recognize the study's potential to impact understanding of cancer biology and possibly influence future research or treatment options, reflecting a perception of high impact.

Abstract in brief

This study investigates how mutations in long noncoding RNAs (lncRNAs), which are typically involved in gene regulation, can directly influence tumor cell fitness and promote cancer progression.
Researchers analyzed thousands of tumor samples and identified 54 lncRNAs with mutations that are positively selected, meaning these mutations may confer advantages to cancer cells; one key example is NEAT1, where specific mutations increase cell proliferation and tumor growth.
Experimental evidence showed that introducing tumor-like mutations into NEAT1 enhances cell fitness and alters its structure, supporting the idea that certain somatic mutations in lncRNAs can act as driver mutations to promote cancer development.

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Tumor Mutations in Long Noncoding RNAs Promote Cancer Cell Growth

This study explores how mutations in long noncoding RNAs influence tumor cell fitness and cancer progression. Researchers identified mutations in 54 lncRNAs, such as NEAT1, that enhance cell proliferation and tumor…

STEM RTCL TV · Sep 17, 2023 27 views

Michael Alexanian

@m_alexanian · X

RT @NCCR_RNADisease: Publication by the lab of @_Rory_Johnson_ & collaborators (@GOLDLab_UCD, former @unibern ) w/ first authors @RobertaE…

Jun 30, 2023 · 4 shares · 1,221 followers View post →

Rory Johnson

@_Rory_Johnson_ · X

RT @NCCR_RNADisease: Publication by the lab of @_Rory_Johnson_ & collaborators (@GOLDLab_UCD, former @unibern ) w/ first authors @RobertaE…

Jun 30, 2023 · 4 shares · 502 followers View post →

Roberta Esposito

@RobertaEs · X

RT @NCCR_RNADisease: Publication by the lab of @_Rory_Johnson_ & collaborators (@GOLDLab_UCD, former @unibern ) w/ first authors @RobertaE…

Jun 30, 2023 · 4 shares · 152 followers View post →

Universität Bern

@unibern · X

RT @NCCR_RNADisease: Publication by the lab of @_Rory_Johnson_ & collaborators (@GOLDLab_UCD, former @unibern ) w/ first authors @RobertaE…

Jun 30, 2023 · 4 shares · 19,668 followers View post →

NCCR RNA & Disease

@NCCR_RNADisease · X

Jun 30, 2023 · 2 likes · 4 shares · 1,416 followers View post →

Tumour mutations in long noncoding RNAs enhance cell fitness.

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Where it's discussed

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Tumor Mutations in Long Noncoding RNAs Promote Cancer Cell Growth