Metab Eng July 2023 PMID 37301359

Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural network.

Vikas Upadhyay, Veda Sheersh Boorla, Costas D Maranas

Mentions

10
Peak: 6 in Jun 2023
across 3 sources since Jun 2023

Extended reach

37,207
potential audience

Total likes

23

Video views

126

Mentions per month

Jun 2023 – May 2025

Where it's discussed

  • X / Twitter6 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

The overall tone reflects a positive perception of the article's significance, with phrases like 'revolutionary method' and 'game-changer' implying high interest and perceived impact. Technical references, such as enzyme reengineering and neural network models, demonstrate engagement and understanding of the subject, shaping a consensus that this work could advance bioengineering fields.

AgreementModerate agreement

Most discussions acknowledge the relevance of the research, with some expressing strong support for its potential, indicating general agreement on its importance.

InterestHigh interest

The discussions show high curiosity and enthusiasm, highlighting excitement about innovative approaches like CNN in enzyme engineering.

EngagementModerate engagement

Participants delve into technical aspects and implications, such as enzyme reengineering methods, reflecting moderate but meaningful engagement.

ImpactModerate impact

Multiple comments suggest the publication could significantly influence future research and practical applications, indicating perceived high impact.

Abstract in brief

  • The text describes EnzRank, a convolutional neural network (CNN) model designed to rank existing enzymes based on their potential for successful reengineering to accept new substrates, which helps improve pathways for producing biofuels, bio-renewables, or bioactive molecules.
  • EnzRank is trained on data from the BRENDA database, using known enzyme-substrate pairs as positives and scrambled pairs as negatives, achieving approximately 80% accuracy in predicting suitable enzyme-substrate interactions.
  • A user-friendly web interface has been developed, allowing users to input substrate SMILES strings and enzyme sequences to easily predict enzyme activity, supporting pathway design and enzyme reengineering efforts for novel biochemical reactions.]

Top posts

Most liked on X and Bluesky
新Mmの憂鬱
@miyatamitsuru · X

AIの応用で酵素をもし自在に設計できるようになると、スマートセルも空想とばかり言えなくなる。 Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural network - PubMed、 https://t.co/WyRa1DwcNS

Jun 11, 2023 · 8 likes · 36,065 followers View post →
Protein Engineering and Directed Evolution Papers
@and_protein · X

Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural network https://t.co/qLl9dpO3Cc

Jun 11, 2023 · 8 likes · 3 shares · 237 followers View post →
David Vallenet
@vallenet · X

RT @bionet_papers: Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neur…

Jun 11, 2023 · 1 share · 302 followers View post →
BioNetPapers
@bionet_papers · X

Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural network https://t.co/4iClrm2bug

Jun 11, 2023 · 1 share · 221 followers View post →
Shiva Shankar S
@BioShankar · X

RT @and_protein: Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural…

Jun 11, 2023 · 3 shares · 162 followers View post →
Omar Arias-Gaguancela, PhD
@omar_arias_g · X

RT @and_protein: Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural…

Jun 11, 2023 · 3 shares · 73 followers View post →

All mentions

新Mmの憂鬱
@miyatamitsuru · X

AIの応用で酵素をもし自在に設計できるようになると、スマートセルも空想とばかり言えなくなる。 Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural network - PubMed、 https://t.co/WyRa1DwcNS

Jun 11, 2023 · 8 likes · 36,065 followers View post →
David Vallenet
@vallenet · X

RT @bionet_papers: Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neur…

Jun 11, 2023 · 1 share · 302 followers View post →
BioNetPapers
@bionet_papers · X

Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural network https://t.co/4iClrm2bug

Jun 11, 2023 · 1 share · 221 followers View post →
Omar Arias-Gaguancela, PhD
@omar_arias_g · X

RT @and_protein: Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural…

Jun 11, 2023 · 3 shares · 73 followers View post →
Shiva Shankar S
@BioShankar · X

RT @and_protein: Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural…

Jun 11, 2023 · 3 shares · 162 followers View post →
Protein Engineering and Directed Evolution Papers
@and_protein · X

Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural network https://t.co/qLl9dpO3Cc

Jun 11, 2023 · 8 likes · 3 shares · 237 followers View post →