AIの応用で酵素をもし自在に設計できるようになると、スマートセルも空想とばかり言えなくなる。 Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural network - PubMed、 https://t.co/WyRa1DwcNS
Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural network.
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Jun 2023 – May 2025Where it's discussed
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X / Twitter6 posts
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The overall tone reflects a positive perception of the article's significance, with phrases like 'revolutionary method' and 'game-changer' implying high interest and perceived impact. Technical references, such as enzyme reengineering and neural network models, demonstrate engagement and understanding of the subject, shaping a consensus that this work could advance bioengineering fields.
Most discussions acknowledge the relevance of the research, with some expressing strong support for its potential, indicating general agreement on its importance.
The discussions show high curiosity and enthusiasm, highlighting excitement about innovative approaches like CNN in enzyme engineering.
Participants delve into technical aspects and implications, such as enzyme reengineering methods, reflecting moderate but meaningful engagement.
Multiple comments suggest the publication could significantly influence future research and practical applications, indicating perceived high impact.
Abstract in brief
- The text describes EnzRank, a convolutional neural network (CNN) model designed to rank existing enzymes based on their potential for successful reengineering to accept new substrates, which helps improve pathways for producing biofuels, bio-renewables, or bioactive molecules.
- EnzRank is trained on data from the BRENDA database, using known enzyme-substrate pairs as positives and scrambled pairs as negatives, achieving approximately 80% accuracy in predicting suitable enzyme-substrate interactions.
- A user-friendly web interface has been developed, allowing users to input substrate SMILES strings and enzyme sequences to easily predict enzyme activity, supporting pathway design and enzyme reengineering efforts for novel biochemical reactions.]
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Most liked on X and BlueskyRank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural network https://t.co/qLl9dpO3Cc
RT @bionet_papers: Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neur…
Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural network https://t.co/4iClrm2bug
RT @and_protein: Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural…
RT @and_protein: Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural…
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AIの応用で酵素をもし自在に設計できるようになると、スマートセルも空想とばかり言えなくなる。 Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural network - PubMed、 https://t.co/WyRa1DwcNS
RT @bionet_papers: Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neur…
Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural network https://t.co/4iClrm2bug
RT @and_protein: Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural…
RT @and_protein: Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural…
Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural network https://t.co/qLl9dpO3Cc