Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function.
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Jun 2023 – Mar 2025Where it's discussed
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X / Twitter101 posts
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News34 articles
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YouTube3 videos
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What people are saying
The overall tone reflects strong support and fascination with the research, with examples such as mentions of HIF-1a as a marker, potential biomarkers, and their implications for diagnosis and therapy, demonstrating both scientific interest and perceived high impact on future treatment strategies.
Most discussions support the findings, emphasizing the role of HIF pathways and potential biomarkers for Long-COVID.
Numerous posts highlight the significance of the research, indicating high curiosity about mechanisms and clinical applications.
Posts involve detailed mentions of molecular pathways, potential biomarkers, and future research directions, showing deep engagement.
The discussions point to a possibly transformative understanding of Long-COVID with implications for diagnostics and treatment.
Abstract in brief
- The study investigates the potential mechanisms behind Long-COVID, focusing on prolonged symptoms following SARS-CoV-2 infection.
- Plasma proteome analysis of Long-COVID patients reveals changes in immune cell activity and signaling pathways, indicating a shift from acute COVID-19 to a vasculo-proliferative state.
- Findings suggest that this process may lead to organ-specific dysfunction, highlighting the importance of understanding these mechanisms for better treatment and prognosis of Long-COVID.
Top posts
Most liked on X and BlueskyPlasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function: Multiple biomarkers were elevated in #LongCovid outpatients and these could point to an immune triggered vascular https://t.co/rYoT2sxcGv
Paper here: "Our findings point to a vasculo-proliferative process in Long-COVID .... Analyses of the plasma proteome, unveiled potential organ-specific prognostic biomarkers and therapeutic targets." https://t.co/xmPltd2nhr https://t.co/sktWD6JPBw
2/1 extrapyramidale und Bewegungsstörungen, ..." Link zur Studie und Dank an @ver_hac für die Info: https://t.co/NLyZQRv1Gn
Belangrijke ontwikkeling voor #LongCOVID-patiënten: onderzoekers hebben unieke bloedplasma-eiwitpatronen ontdekt bij deze patiënten. De ontdekte eiwitten zouden kunnen fungeren als n potentieel doelwit voor medicijnen om deze patiënten te kunnen behandelen https://t.co/5E7A0tWgpt
The Definition of MILD Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function | Journal of Translational Medicine | Full Text https://t.co/NlVHkctOyM
All mentions
Exploring Vascular Dysfunction in Long Covid Symptoms
A promising avenue of research in Long Covid is endothelial and vascular dysfunction. Studies show significant differences in lung pathology due to severe endothelial injury and thrombosis following Covid-19…
Understanding Long COVID: Mechanisms and Patient Impact
This video explores the mechanisms behind Long COVID, focusing on the plasma proteome changes observed in patients. It highlights how these changes may lead to organ-specific dysfunction, emphasizing the need for better…
Understanding Long-COVID: Plasma Proteome Insights and Impacts
This video investigates the plasma proteome of Long-COVID patients, revealing changes in immune activity and signaling. Insights into HIF-mediated vasculo-proliferative disease suggest potential organ-specific…
RT @YujiMarutani: ロングコビッド患者の血漿プロテオームは、HIF(低酸素誘導因子)による血管増殖性疾患であり、脳と心機能に影響を与えることを示しいる https://t.co/wrbAIeDVat
@FatigueMe92484 @JackHadfield14 Note - have been having pretty good clinical success using above framework clinically (focus on microclot, inflammation and capillary blood flow) as a guide. Typically 4-12 wks for results w/pretty simple actions. Article with proteome analysis in LC https://t.co/iwMEYFgW05 https://t.co/irvC27T9AG
@Molbaas @atranscendedman @sunsopeningband Role of Hif-1a in LC? …vascular proliferative state associated with hypoxia inducible factor 1 pathway suggested progression from acute COVID-19 to Long-COVID. https://t.co/5yPOyCfVsW https://t.co/fwA25S0Mki
RT @YujiMarutani: ロングコビッド患者の血漿プロテオームは、HIF(低酸素誘導因子)による血管増殖性疾患であり、脳と心機能に影響を与えることを示しいる https://t.co/wrbAIeDVat
RT @Drdragonfraser: Fresh off the Press - Our Newest Research!! The Long-COVID Plasma Proteome: Mechanisms, Biomarkers and Potential Ther…
Hif-1a is a hypoxia marker, also caused viral reactivation when dysregulated and has been directly implicated in long Covid pathology Also one of my favourite markers https://t.co/Hq2T0OaLV7 https://t.co/41BUdHrpEQ
@CBammerMD Ich auch nicht- hab das vielleicht mit c19 verwechselt. https://t.co/5yPOyCfVsW
RT @Drdragonfraser: Fresh off the Press - Our Newest Research!! The Long-COVID Plasma Proteome: Mechanisms, Biomarkers and Potential Ther…
Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function | Journal of Translational Medicine | Full Text https://t.co/VZOQJZ0MwU
RT @YujiMarutani: ロングコビッド患者の血漿プロテオームは、HIF(低酸素誘導因子)による血管増殖性疾患であり、脳と心機能に影響を与えることを示しいる https://t.co/wrbAIeDVat
RT @LC_ontheshort: @ShaneyWright + ANG-1 has also been found elevated in another study: https://t.co/RQVAKO9xXL
RT @LC_ontheshort: @ShaneyWright + ANG-1 has also been found elevated in another study: https://t.co/RQVAKO9xXL
RT @LC_ontheshort: @ShaneyWright + ANG-1 has also been found elevated in another study: https://t.co/RQVAKO9xXL
@ShaneyWright + ANG-1 has also been found elevated in another study: https://t.co/RQVAKO9xXL
RT @LC_ontheshort: And now after the excitement, there is still so much work to be done obviously! But I am very happy about this :) (min…
And now after the excitement, there is still so much work to be done obviously! But I am very happy about this :) (mind you ANG-1 has already been found elevated in #LongCovid in another paper that looked at the HIF-a pathway: https://t.co/RQVAKO9xXL)
@doctorasadkhan @dbkell @resiapretorius @FvRhijn P selectin findings from this wonderful paper https://t.co/DriEAm08f8 A point of care test is currently in development
Quite exciting as well is that the pathway regulated by a transcription factor called hypoxia-inducing factor 1 (HIF-1) might be able to predict who is going to develop #LongCovid. https://t.co/RQVAKO9xXL
@MarkELindsay @MarkELindsay have you written something - even a tweet - about the paper linked? Would be curious to hear your opinion. https://t.co/RQVAKO9xXL
@BMG_Bund Wie erkenne ich denn #LongCovid? Es braucht Forschung und die Anerkennung von Biomarkern! Zum Beispiel: WASF3: https://t.co/zPArxssi1C Diverse Biomarker: https://t.co/KLmtStH1jS
When vessels choke. "Our findings point to a vasculo-proliferative process in Long-COVID that is likely initiated by either prior hypoxia (localized or systemic) and/or stimulatory factors (i.e., cytokines, chemokines, growth factors, angiotensin, etc)." https://t.co/FOOo9xUPGl
Researchers discover unique blood plasma protein patterns in patients with long COVID https://t.co/n79DqdxcjK https://t.co/MyiEJbrqZy https://t.co/qlZaMhJunQ
@Ninjazz636 I’m not sure what’s been swept under the rug? This particular research program has continued with another big publication a few weeks ago https://t.co/68lGGQjHu1
"Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function" Iosef C [..] Fraser DD. J Transl Med. 2023-06-10. https://t.co/FLcZ1xOOHX
2️⃣ 2023 07 11 Mediante el uso de tecnología avanzada, los investigadores pudieron determinar patrones de señalización únicos a partir de las proteínas de la sangre. https://t.co/9fMpiNB2gg
RT @Signal9J: 査読付『Long Covid患者の血漿プロテオームは、脳と心臓の機能に影響を与える HIF 媒介の血管増殖性疾患を示している』 Long Covid患者では血漿のタンパク質に独特のパターンがあるみたい、と。 https://t.co/1dIa7Rn…
査読付『Long Covid患者の血漿プロテオームは、脳と心臓の機能に影響を与える HIF 媒介の血管増殖性疾患を示している』 Long Covid患者では血漿のタンパク質に独特のパターンがあるみたい、と。 https://t.co/1dIa7RnSNE
Iosef, C., Knauer, M.J., Nicholson, M. et al. Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function. J Transl Med 21, 377 (2023). https://t.co/RAaI5yFVoO https://t.co/NPZ5vaym0W
Examining the plasma proteome to identify the reasons for #longCOVID. Findings point to a vasculo-proliferative process. Framed as approach to new drugs but we really need good biomarker https://t.co/2TOtm6tw5i
RT @RTHM_Health:
Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function https://t.co/FAj4wHB7i2 https://t.co/zURVwHLAoe @WHO @ICMRDELHI @NobelPrize @NMC_IND @NITIAayog @aiims_newdelhi @OfficialJipmer @iitmadras @iitgn https://t.co/faYh0PeHQT
RT @radsci: Insufficiently noticed paper: https://t.co/muMkAPT5SX #LongCovid #PASC #COVIDIsNotMild #ProtectYourBrain https://t.co/AN5gth…
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@BanounHelene @SabatierJeanMa1 @narfgb https://t.co/tLLcd4olBU https://t.co/4D0yH6mz8i
RT @LongCovidSOS: Paper here: "Our findings point to a vasculo-proliferative process in Long-COVID .... Analyses of the plasma proteome,…
RT @LongCovidSOS: Paper here: "Our findings point to a vasculo-proliferative process in Long-COVID .... Analyses of the plasma proteome,…
RT @Bijan63: Belangrijke ontwikkeling voor #LongCOVID-patiënten: onderzoekers hebben unieke bloedplasma-eiwitpatronen ontdekt bij deze pati…
RT @Bijan63: Belangrijke ontwikkeling voor #LongCOVID-patiënten: onderzoekers hebben unieke bloedplasma-eiwitpatronen ontdekt bij deze pati…
RT @Bijan63: Belangrijke ontwikkeling voor #LongCOVID-patiënten: onderzoekers hebben unieke bloedplasma-eiwitpatronen ontdekt bij deze pati…
RT @Drdragonfraser: Fresh off the Press - Our Newest Research!! The Long-COVID Plasma Proteome: Mechanisms, Biomarkers and Potential Ther…
RT @LongCovidSOS: Paper here: "Our findings point to a vasculo-proliferative process in Long-COVID .... Analyses of the plasma proteome,…
RT @LongCovidSOS: Paper here: "Our findings point to a vasculo-proliferative process in Long-COVID .... Analyses of the plasma proteome,…
RT @Bijan63: Belangrijke ontwikkeling voor #LongCOVID-patiënten: onderzoekers hebben unieke bloedplasma-eiwitpatronen ontdekt bij deze pati…
RT @Bijan63: Belangrijke ontwikkeling voor #LongCOVID-patiënten: onderzoekers hebben unieke bloedplasma-eiwitpatronen ontdekt bij deze pati…
RT @Bijan63: Belangrijke ontwikkeling voor #LongCOVID-patiënten: onderzoekers hebben unieke bloedplasma-eiwitpatronen ontdekt bij deze pati…
https://t.co/eSS23I7Kx5
Belangrijke ontwikkeling voor #LongCOVID-patiënten: onderzoekers hebben unieke bloedplasma-eiwitpatronen ontdekt bij deze patiënten. De ontdekte eiwitten zouden kunnen fungeren als n potentieel doelwit voor medicijnen om deze patiënten te kunnen behandelen https://t.co/5E7A0tWgpt
RT @LongCovidSOS: Paper here: "Our findings point to a vasculo-proliferative process in Long-COVID .... Analyses of the plasma proteome,…
Paper here: "Our findings point to a vasculo-proliferative process in Long-COVID .... Analyses of the plasma proteome, unveiled potential organ-specific prognostic biomarkers and therapeutic targets." https://t.co/xmPltd2nhr https://t.co/sktWD6JPBw
RT @1goodtern: @loscharlos And more to follow. https://t.co/WvK4jjhtCa
@loscharlos And more to follow. https://t.co/WvK4jjhtCa
"Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function" https://t.co/Nw7XZ1oKuQ
RT @Drdragonfraser: Fresh off the Press - Our Newest Research!! The Long-COVID Plasma Proteome: Mechanisms, Biomarkers and Potential Ther…
RT @Pflegeherz12: 2/1 extrapyramidale und Bewegungsstörungen, ..." Link zur Studie und Dank an @ver_hac für die Info: https://t.co/NLyZQ…
RT @radsci: Insufficiently noticed paper: https://t.co/muMkAPT5SX #LongCovid #PASC #COVIDIsNotMild #ProtectYourBrain https://t.co/AN5gth…
2/1 extrapyramidale und Bewegungsstörungen, ..." Link zur Studie und Dank an @ver_hac für die Info: https://t.co/NLyZQRv1Gn
Insufficiently noticed paper: https://t.co/muMkAPT5SX #LongCovid #PASC #COVIDIsNotMild #ProtectYourBrain https://t.co/AN5gthHILx
RT @SchiefferDr: Proteomanalysis in Long Covid . Inflammation, TNF and VEGF affected. https://t.co/569BQLpivz
RT @pamelarbishop: Link to research article: https://t.co/vrwdibEMAY
Link to research article: https://t.co/vrwdibEMAY
Proteomanalysis in Long Covid . Inflammation, TNF and VEGF affected. https://t.co/569BQLpivz
RT @Drdragonfraser: Fresh off the Press - Our Newest Research!! The Long-COVID Plasma Proteome: Mechanisms, Biomarkers and Potential Ther…
RT @Drdragonfraser: Fresh off the Press - Our Newest Research!! The Long-COVID Plasma Proteome: Mechanisms, Biomarkers and Potential Ther…
RT @Drdragonfraser: Fresh off the Press - Our Newest Research!! The Long-COVID Plasma Proteome: Mechanisms, Biomarkers and Potential Ther…
RT @Drdragonfraser: Fresh off the Press - Our Newest Research!! The Long-COVID Plasma Proteome: Mechanisms, Biomarkers and Potential Ther…
RT @Drdragonfraser: Fresh off the Press - Our Newest Research!! The Long-COVID Plasma Proteome: Mechanisms, Biomarkers and Potential Ther…
RT @Drdragonfraser: Fresh off the Press - Our Newest Research!! The Long-COVID Plasma Proteome: Mechanisms, Biomarkers and Potential Ther…
Paper: "Analyses of the plasma proteome, used as a surrogate for cellular signaling, unveiled potential organ-specific prognostic biomarkers and therapeutic targets." https://t.co/XAOrpBj0CY
RT @NohaAboelataMD: Important & fascinating findings on #longcovid! The plasma proteome, including the expression of 3072 plasma proteins,…
RT @leseerlaubnis: Am Blutplasma kann man klare Unterschiede zwischen gesunden Menschen und Menschen mit LongCovid erkennen. Man muss woh…
RT @leseerlaubnis: Am Blutplasma kann man klare Unterschiede zwischen gesunden Menschen und Menschen mit LongCovid erkennen. Man muss woh…
RT @leseerlaubnis: Am Blutplasma kann man klare Unterschiede zwischen gesunden Menschen und Menschen mit LongCovid erkennen. Man muss woh…
RT @leseerlaubnis: Am Blutplasma kann man klare Unterschiede zwischen gesunden Menschen und Menschen mit LongCovid erkennen. Man muss woh…
RT @leseerlaubnis: Am Blutplasma kann man klare Unterschiede zwischen gesunden Menschen und Menschen mit LongCovid erkennen. Man muss woh…
RT @leseerlaubnis: Am Blutplasma kann man klare Unterschiede zwischen gesunden Menschen und Menschen mit LongCovid erkennen. Man muss woh…
RT @leseerlaubnis: Am Blutplasma kann man klare Unterschiede zwischen gesunden Menschen und Menschen mit LongCovid erkennen. Man muss woh…
RT @RWittenbrink: bei #LongCovid und die Entwicklung potenzieller therapeutischer Ziele für die Vorbeugung und/oder Behandlung der Krankhei…
Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function https://t.co/iyPPzp5VQJ
Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function — Iosef et al. https://t.co/tm7iopusWK 7/9
RT @ValeBodi: Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart fu…
Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function https://t.co/qwOb4iLxuE
RT @ValeBodi: Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart fu…
RT @HatragyiSafarne: Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and h…
Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function: Multiple biomarkers were elevated in #LongCovid outpatients and these could point to an immune triggered vascular https://t.co/rYoT2sxcGv
Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function.
The Definition of MILD Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function | Journal of Translational Medicine | Full Text https://t.co/NlVHkctOyM
Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function https://t.co/hcGf87YSg9
Plasma proteome of Long-COVID patients indicates HIF-mediated vasculo-proliferative disease with impact on brain and heart function #LongCovid #pwLC https://t.co/wpCExl8Nnk