Moderate exercise induces trained immunity in macrophages.

Mayoorey Murugathasan, Ardavan Jafari, Amandeep Amandeep, Syed A Hassan, Matthew Chihata, Ali A Abdul-Sater

August 2023

Synopsis of Social media discussions

The discussions around this publication frequently emphasize the significance of moderate exercise for boosting immunity, using words like 'important,' 'beneficial,' and phrases like 'may help immunity' to express support. Several comments delve into mechanistic details, such as reprogramming macrophage metabolism and epigenetic landscapes, which show a deep engagement with the scientific concepts and suggest recognition of the research’s potential to influence future health strategies.

A
Agreement
 Strong agreement

Most posts strongly support the findings, emphasizing the positive role of moderate exercise in immune response and training macrophages, often using affirming words like 'important,' 'beneficial,' and 'increases.'

I
Interest
 High level of interest

Discussions demonstrate high interest by highlighting the significance of the research, with comments such as 'The importance of exercise increases every day' and calling the findings a 'game changer,' reflecting curiosity and perceived relevance.

E
Engagement
 High engagement

Many posts delve into technical details, referencing mechanisms like metabolism, mitochondrial function, and epigenetics, indicating deep engagement with the scientific content.

I
Impact
 Moderate level of impact

Although some users suggest it could influence health practices and medical understanding positively, the perceived impact is slightly moderate as discussions mainly focus on potential rather than immediate, broad societal change.

Social Mentions

YouTube

3 Videos

Facebook

2 Posts

Twitter

32 Posts

Blogs

4 Articles

News

15 Articles

Reddit

2 Posts

Metrics

Video Views

148,347

Total Likes

3,743

Extended Reach

286,951

Social Features

58

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

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1,254 views

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This video explores groundbreaking research showing that moderate exercise induces long-lasting changes in macrophages, immune cells responsible for inflammation. These changes improve their function, reduce inflammatory responses, and may help prevent inflammation-related diseases.

Fitness TitBitz

June 24, 2023

200 views

  • Rowena's
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    August 18, 2025

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    August 18, 2025

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    July 26, 2023

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    July 26, 2023

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  • AJP-Cell Physiology
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    The importance of #exercise increases every day as this #ArtilceinPress shows it may also help immunity. Moderate exercise induces trained immunity in macrophages (Mayoorey Murugathasan et al.): https://t.co/vtzcAquR9m @MHRC_YorkU #Inflammation #Mitochondria https://t.co/s06YDBzihS
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    July 11, 2023

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    July 5, 2023

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  • AJP-Cell Physiology
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    July 5, 2023

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  • UoL Movement & Physical Activity Research Network
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    Researchers at @UniOfYork have expanded the current knowledge on the beneficial role of exercise on the body’s response to inflammation, indicating that this may increase the production of macrophages (white blood cells that kill off infections) https://t.co/IZ5glG6rkp
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    July 3, 2023

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    .@AJPCellPhys article (https://t.co/bDuqQx4rtj) is cited in “Cardio Curbs Excessive Inflammation in Surprising Ways” from @PsychToday: https://t.co/LsoP5uMXYr CC: @AJPCellPhysEIC
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    June 19, 2023

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    RT @immUNode: 運動が炎症に効くのって何でなの？ 中程度の運動は骨髄由来マクロファージにおいて呼吸、グルコースの代謝、DNAアクセスなどの再構築を促すことで炎症性遺伝子の発現や活性酸素の産生を抑制するらしい どのワークアウトが特にいいとかも気になるな https…
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    @jumbo_hakodate (Twitter)

    RT @immUNode: 運動が炎症に効くのって何でなの？ 中程度の運動は骨髄由来マクロファージにおいて呼吸、グルコースの代謝、DNAアクセスなどの再構築を促すことで炎症性遺伝子の発現や活性酸素の産生を抑制するらしい どのワークアウトが特にいいとかも気になるな https…
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    June 18, 2023

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    @shigekzishihara (Twitter)

    RT @immUNode: 運動が炎症に効くのって何でなの？ 中程度の運動は骨髄由来マクロファージにおいて呼吸、グルコースの代謝、DNAアクセスなどの再構築を促すことで炎症性遺伝子の発現や活性酸素の産生を抑制するらしい どのワークアウトが特にいいとかも気になるな https…
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    June 18, 2023

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  • Immu node
    @immUNode (Twitter)

    運動が炎症に効くのって何でなの？ 中程度の運動は骨髄由来マクロファージにおいて呼吸、グルコースの代謝、DNAアクセスなどの再構築を促すことで炎症性遺伝子の発現や活性酸素の産生を抑制するらしい どのワークアウトが特にいいとかも気になるな https://t.co/dn9sWezjjQ
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    June 18, 2023

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  • Ben Kirk, PhD
    @DrBenKirk (Twitter)

    RT @Osteoporosis_NL: Chronic moderate exercise can influence the inflammatory responses of macrophages by reprogramming their metabolic and…
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    @APSPublications (Twitter)

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Abstract Synopsis

  • Moderate exercise causes long-lasting changes in macrophages, the immune cells responsible for inflammation, by altering their metabolism and how their genes are accessed (epigenetic landscape).
  • These changes lead to a reduction in inflammatory responses, such as decreased activation of inflammatory pathways and increased expression of anti-inflammatory (M2-like) genes, ultimately helping prevent inflammation-related diseases.
  • The process involves improved mitochondrial function, increased reliance on oxygen-based energy production, and modifications in chromatin accessibility, which together help macrophages respond more efficiently to threats while minimizing tissue damage.