August 2023 PMID 37306389

Moderate exercise induces trained immunity in macrophages.

Mayoorey Murugathasan, Ardavan Jafari, Amandeep Amandeep, Syed A Hassan, Matthew Chihata, Ali A Abdul-Sater

Mentions

58
Peak: 23 in Jun 2023
across 6 sources since Jun 2023

Extended reach

286,951
potential audience

Total likes

3,743

Video views

148,347

Mentions per month

Jun 2023 – Aug 2025

Where it's discussed

  • X / Twitter32 posts
  • News15 articles
  • Blogs4 articles
  • YouTube3 videos
  • Facebook2 posts
  • Reddit2 posts

AI synopsis

What people are saying

The discussions around this publication frequently emphasize the significance of moderate exercise for boosting immunity, using words like 'important,' 'beneficial,' and phrases like 'may help immunity' to express support. Several comments delve into mechanistic details, such as reprogramming macrophage metabolism and epigenetic landscapes, which show a deep engagement with the scientific concepts and suggest recognition of the research’s potential to influence future health strategies.

AgreementStrong agreement

Most posts strongly support the findings, emphasizing the positive role of moderate exercise in immune response and training macrophages, often using affirming words like 'important,' 'beneficial,' and 'increases.'

InterestHigh interest

Discussions demonstrate high interest by highlighting the significance of the research, with comments such as 'The importance of exercise increases every day' and calling the findings a 'game changer,' reflecting curiosity and perceived relevance.

EngagementHigh engagement

Many posts delve into technical details, referencing mechanisms like metabolism, mitochondrial function, and epigenetics, indicating deep engagement with the scientific content.

ImpactModerate impact

Although some users suggest it could influence health practices and medical understanding positively, the perceived impact is slightly moderate as discussions mainly focus on potential rather than immediate, broad societal change.

Abstract in brief

  • Moderate exercise causes long-lasting changes in macrophages, the immune cells responsible for inflammation, by altering their metabolism and how their genes are accessed (epigenetic landscape).
  • These changes lead to a reduction in inflammatory responses, such as decreased activation of inflammatory pathways and increased expression of anti-inflammatory (M2-like) genes, ultimately helping prevent inflammation-related diseases.
  • The process involves improved mitochondrial function, increased reliance on oxygen-based energy production, and modifications in chromatin accessibility, which together help macrophages respond more efficiently to threats while minimizing tissue damage.

Top posts

Most liked on X and Bluesky
APS Publications
@APSPublications · X

New in @AJPCell: Murugathasan et al. found that chronic moderate #exercise can influence the inflammatory responses of #macrophages by reprogramming their metabolic & #epigenetic landscape. https://t.co/4ankW6ufXQ @MHRC_YorkU @YorkUHealth @aabdulsater #Mitochondria https://t.co/y1tryTv21Q

Jun 13, 2023 · 26 likes · 9 shares · 7,362 followers View post →
Immu node
@immUNode · X

運動が炎症に効くのって何でなの? 中程度の運動は骨髄由来マクロファージにおいて呼吸、グルコースの代謝、DNAアクセスなどの再構築を促すことで炎症性遺伝子の発現や活性酸素の産生を抑制するらしい どのワークアウトが特にいいとかも気になるな https://t.co/dn9sWezjjQ

Jun 18, 2023 · 21 likes · 4 shares · 280 followers View post →
Osteoporosis-NL @osteoporosis-nl.bsky.social
@Osteoporosis_NL · X

Chronic moderate exercise can influence the inflammatory responses of macrophages by reprogramming their metabolic and epigenetic landscape. M Murugathasan et al. Am J Physiol Cell Physiol 2023 Jun 12 https://t.co/1G2bcNHWnC …trained immunity https://t.co/HvIFKNW1uv

Jun 16, 2023 · 12 likes · 7 shares · 3,383 followers View post →
AJP-Cell Physiology
@AJPCellPhys · X

Another reminder to get to the gym, Mayoorey Murugathasan et al. authored today's #ArticleinPress Moderate exercise induces trained immunity in macrophages: https://t.co/uzlSDucgo4 @YorkUHealth #Exercise #Inflammation https://t.co/zQq0LmG5MC

Jul 5, 2023 · 9 likes · 5 shares · 3,436 followers View post →
Agingdoc
@agingdoc1 · X

Moderate exercise induces trained immunity in macrophages https://t.co/skoctiyI4F @AJPCellPhys https://t.co/OdaNPAv6ZU

Jun 16, 2023 · 8 likes · 3 shares · 41,698 followers View post →
AJP-Cell Physiology
@AJPCellPhys · X

The importance of #exercise increases every day as this #ArtilceinPress shows it may also help immunity. Moderate exercise induces trained immunity in macrophages (Mayoorey Murugathasan et al.): https://t.co/vtzcAquR9m @MHRC_YorkU #Inflammation #Mitochondria https://t.co/s06YDBzihS

Jul 26, 2023 · 6 likes · 3 shares · 3,436 followers View post →

All mentions

Rowena's
@the_meat_market · X

Watch the full video here: https://t.co/wrhrdQDDYL

Aug 18, 2025 · 271 followers View post →
Leslie Dwyer
@RealLeslieDwyer · X

https://t.co/RRdXnIeDGY

Aug 18, 2025 · 184 followers View post →
Liliana Schaefer, MD
@AJPCellPhysEIC · X

RT @AJPCellPhys: The importance of #exercise increases every day as this #ArtilceinPress shows it may also help immunity. Moderate exercise…

Jul 26, 2023 · 3 shares · 861 followers View post →
Brian A. Irving, PhD, FACSM
@MitoPhys · X

RT @AJPCellPhys: The importance of #exercise increases every day as this #ArtilceinPress shows it may also help immunity. Moderate exercise…

Jul 26, 2023 · 3 shares · 1,370 followers View post →
APS Publications
@APSPublications · X

RT @AJPCellPhys: The importance of #exercise increases every day as this #ArtilceinPress shows it may also help immunity. Moderate exercise…

Jul 26, 2023 · 3 shares · 7,362 followers View post →
AJP-Cell Physiology
@AJPCellPhys · X

The importance of #exercise increases every day as this #ArtilceinPress shows it may also help immunity. Moderate exercise induces trained immunity in macrophages (Mayoorey Murugathasan et al.): https://t.co/vtzcAquR9m @MHRC_YorkU #Inflammation #Mitochondria https://t.co/s06YDBzihS

Jul 26, 2023 · 6 likes · 3 shares · 3,436 followers View post →
AJP-Cell Physiology
@AJPCellPhys · X

RT @APSPhysiology: .@AJPCellPhys article (https://t.co/bDuqQx4rtj) is cited in “Cardio Curbs Excessive Inflammation in Surprising Ways” fro…

Jul 11, 2023 · 3 shares · 3,436 followers View post →
APS Publications
@APSPublications · X

RT @AJPCellPhys: Another reminder to get to the gym, Mayoorey Murugathasan et al. authored today's #ArticleinPress Moderate exercise induce…

Jul 5, 2023 · 5 shares · 7,362 followers View post →
AJP-Cell Physiology
@AJPCellPhys · X

Another reminder to get to the gym, Mayoorey Murugathasan et al. authored today's #ArticleinPress Moderate exercise induces trained immunity in macrophages: https://t.co/uzlSDucgo4 @YorkUHealth #Exercise #Inflammation https://t.co/zQq0LmG5MC

Jul 5, 2023 · 9 likes · 5 shares · 3,436 followers View post →
UoL Movement & Physical Activity Research Network
@InterActiveUoL · X

Researchers at @UniOfYork have expanded the current knowledge on the beneficial role of exercise on the body’s response to inflammation, indicating that this may increase the production of macrophages (white blood cells that kill off infections) https://t.co/IZ5glG6rkp

Jul 3, 2023 · 1 like · 188 followers View post →
Liliana Schaefer, MD
@AJPCellPhysEIC · X

RT @APSPhysiology: .@AJPCellPhys article (https://t.co/bDuqQx4rtj) is cited in “Cardio Curbs Excessive Inflammation in Surprising Ways” fro…

Jun 26, 2023 · 3 shares · 861 followers View post →
JorgeEdoChava75
@QicenoJorge · X

RT @APSPhysiology: .@AJPCellPhys article (https://t.co/bDuqQx4rtj) is cited in “Cardio Curbs Excessive Inflammation in Surprising Ways” fro…

Jun 26, 2023 · 3 shares · 1,002 followers View post →
American Physiological Society
@APSPhysiology · X

.@AJPCellPhys article (https://t.co/bDuqQx4rtj) is cited in “Cardio Curbs Excessive Inflammation in Surprising Ways” from @PsychToday: https://t.co/LsoP5uMXYr CC: @AJPCellPhysEIC

Jun 26, 2023 · 4 likes · 3 shares · 13,978 followers View post →
Keizo Nishikawa
@ihaveapenpai · X

RT @immUNode: 運動が炎症に効くのって何でなの? 中程度の運動は骨髄由来マクロファージにおいて呼吸、グルコースの代謝、DNAアクセスなどの再構築を促すことで炎症性遺伝子の発現や活性酸素の産生を抑制するらしい どのワークアウトが特にいいとかも気になるな https…

Jun 19, 2023 · 4 shares · 54 followers View post →
Alex
@AlexViKu · X

Moderate exercise induces trained immunity in macrophages | American Journal of Physiology-Cell Physiology https://t.co/NwUOuAAs6K

Jun 19, 2023 · 97 followers View post →
Satoru Ato / 阿藤聡
@SatoruAto · X

RT @immUNode: 運動が炎症に効くのって何でなの? 中程度の運動は骨髄由来マクロファージにおいて呼吸、グルコースの代謝、DNAアクセスなどの再構築を促すことで炎症性遺伝子の発現や活性酸素の産生を抑制するらしい どのワークアウトが特にいいとかも気になるな https…

Jun 18, 2023 · 4 shares · 422 followers View post →
仕事寄りのジャンボ(中村拓也)
@jumbo_hakodate · X

RT @immUNode: 運動が炎症に効くのって何でなの? 中程度の運動は骨髄由来マクロファージにおいて呼吸、グルコースの代謝、DNAアクセスなどの再構築を促すことで炎症性遺伝子の発現や活性酸素の産生を抑制するらしい どのワークアウトが特にいいとかも気になるな https…

Jun 18, 2023 · 4 shares · 1,539 followers View post →
Shigekazu Ishihara
@shigekzishihara · X

RT @immUNode: 運動が炎症に効くのって何でなの? 中程度の運動は骨髄由来マクロファージにおいて呼吸、グルコースの代謝、DNAアクセスなどの再構築を促すことで炎症性遺伝子の発現や活性酸素の産生を抑制するらしい どのワークアウトが特にいいとかも気になるな https…

Jun 18, 2023 · 4 shares · 7,056 followers View post →
Immu node
@immUNode · X

運動が炎症に効くのって何でなの? 中程度の運動は骨髄由来マクロファージにおいて呼吸、グルコースの代謝、DNAアクセスなどの再構築を促すことで炎症性遺伝子の発現や活性酸素の産生を抑制するらしい どのワークアウトが特にいいとかも気になるな https://t.co/dn9sWezjjQ

Jun 18, 2023 · 21 likes · 4 shares · 280 followers View post →
Ben Kirk, PhD
@DrBenKirk · X

RT @Osteoporosis_NL: Chronic moderate exercise can influence the inflammatory responses of macrophages by reprogramming their metabolic and…

Jun 16, 2023 · 7 shares · 2,234 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Moderate exercise induces trained immunity in macrophages https://t.co/skoctiyI4F @AJPCellPhys https://t.co/OdaNPAv6ZU

Jun 16, 2023 · 3 shares · 133 followers View post →
Patty T CNP
@PattyT_NP · X

RT @Osteoporosis_NL: Chronic moderate exercise can influence the inflammatory responses of macrophages by reprogramming their metabolic and…

Jun 16, 2023 · 7 shares · 367 followers View post →
Dr. Elena Seranova
@ESeranova · X

RT @agingdoc1: Moderate exercise induces trained immunity in macrophages https://t.co/skoctiyI4F @AJPCellPhys https://t.co/OdaNPAv6ZU

Jun 16, 2023 · 3 shares · 1,255 followers View post →
Dr Celestino Gutiérrez González MD
@CelestinoGutirr · X

RT @Osteoporosis_NL: Chronic moderate exercise can influence the inflammatory responses of macrophages by reprogramming their metabolic and…

Jun 16, 2023 · 7 shares · 11,310 followers View post →
Vicente Lozada-Balderrama
@VicenteLozadaB · X

RT @Osteoporosis_NL: Chronic moderate exercise can influence the inflammatory responses of macrophages by reprogramming their metabolic and…

Jun 16, 2023 · 7 shares · 13,639 followers View post →
VENEZUELA HERMOSA
@rodriguezb5 · X

RT @Osteoporosis_NL: Chronic moderate exercise can influence the inflammatory responses of macrophages by reprogramming their metabolic and…

Jun 16, 2023 · 7 shares · 388 followers View post →
サイエンスあれこれ
@sarekore · X

として機能する白血球ですが、時として癌や自己免疫疾患の原因となる過剰な炎症を起こすこともあります。適度な運動が、骨髄内のマクロファージ前駆体の代謝およびエピジェネティックな調節を再プログラムすることによって、過剰な炎症反応を和らげることが明らかになりましたhttps://t.co/ojm1SfjBQ7

Jun 16, 2023 · 1 like · 921 followers View post →
Osteoporosis-NL @osteoporosis-nl.bsky.social
@Osteoporosis_NL · X

Chronic moderate exercise can influence the inflammatory responses of macrophages by reprogramming their metabolic and epigenetic landscape. M Murugathasan et al. Am J Physiol Cell Physiol 2023 Jun 12 https://t.co/1G2bcNHWnC …trained immunity https://t.co/HvIFKNW1uv

Jun 16, 2023 · 12 likes · 7 shares · 3,383 followers View post →
Agingdoc
@agingdoc1 · X

Moderate exercise induces trained immunity in macrophages https://t.co/skoctiyI4F @AJPCellPhys https://t.co/OdaNPAv6ZU

Jun 16, 2023 · 8 likes · 3 shares · 41,698 followers View post →
Mitochondrial News
@MitochondriaNe1 · X

Moderate exercise induces trained immunity in macrophages https://t.co/e919jlipLQ https://t.co/BLo4SFY4q5

Jun 14, 2023 · 2,255 followers View post →
Rod FK
@RodFK01 · X

RT @APSPublications: New in @AJPCell: Murugathasan et al. found that chronic moderate #exercise can influence the inflammatory responses of…

Jun 13, 2023 · 9 shares · 219 followers View post →
APS Publications
@APSPublications · X

New in @AJPCell: Murugathasan et al. found that chronic moderate #exercise can influence the inflammatory responses of #macrophages by reprogramming their metabolic & #epigenetic landscape. https://t.co/4ankW6ufXQ @MHRC_YorkU @YorkUHealth @aabdulsater #Mitochondria https://t.co/y1tryTv21Q

Jun 13, 2023 · 26 likes · 9 shares · 7,362 followers View post →