PubHawk
PLoS Biol June 2023 PMID 37310920

DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner.

Madison S Strine, Wesley L Cai, Jin Wei, Mia Madel Alfajaro, Renata B Filler, Scott B Biering, Sylvia Sarnik, Ryan D Chow, Ajinkya Patil, Kasey S Cervantes, Clayton K Collings, Peter C DeWeirdt, Ruth E Hanna, Kevin Schofield, Christopher Hulme

Full text PDF Download social card

Mentions

43
Peak: 20 in Jun 2023
across 5 sources since Jun 2023

Extended reach

1,675,339
potential audience

Total likes

36

Video views

135

Mentions per month

Jun 2023 – Aug 2024

Where it's discussed

  • X / Twitter24 posts
  • News14 articles
  • Facebook2 posts
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The collected discussions clearly show enthusiasm for the discovery that DYRK1A influences coronavirus entry through epigenetic mechanisms, with phrases like 'new drug target' and 'important insight' underscoring the perceived importance and potential impact of this research, while scientific detail and references to mechanisms reflect active and engaged analysis.

AgreementStrong agreement

Most discussions are highly supportive, emphasizing the importance of DYRK1A in viral entry and potential therapeutic implications.

InterestHigh interest

The discussions demonstrate strong interest, highlighting detailed mechanisms and future research directions.

EngagementModerate engagement

The posts show active engagement with mentions of molecular mechanisms, gene regulation, and potential drug targets, indicating a deep understanding of the research.

ImpactHigh impact

Many posts suggest that the findings could significantly influence coronavirus treatment strategies and epigenetic research, indicating high perceived impact.

Abstract in brief

  • DYRK1A enhances the entry of dangerous human coronaviruses like SARS-CoV, SARS-CoV-2, and MERS-CoV by increasing the expression of the receptors ACE2 and DPP4, and this process does not depend on its kinase activity.
  • The protein promotes gene transcription by making DNA more accessible at the ACE2 gene’s promoter and an enhancer region, aiding the virus's ability to infect cells.
  • This function of DYRK1A is conserved across different species, including humans and non-human primates, making it a potential target for therapies to prevent coronavirus infections.
Read the full abstract

Top posts

Most liked on X and Bluesky
PLOS Biology
@PLOSBiology · X

The kinase DYRK1A can aid #coronavirus entry by driving #chromatin accessibility & active transcription at coronavirus receptor gene loci, independent of its catalytic function #SARSCoV2 #SARSCoV #MERSCoV @madisonstrine &co @WilenLab #PLOSBiology https://t.co/5CaR7ndoC9 https://t.co/3IdoGi5GFj

Jun 14, 2023 · 9 likes · 5 shares · 103,150 followers View post →
PLOS Biology
@PLOSBiology · X

The kinase DYRK1A can aid #coronavirus entry by driving #chromatin accessibility & active transcription at coronavirus receptor gene loci, independent of its catalytic function #SARSCoV2 #SARSCoV #MERSCoV @madisonstrine &co @WilenLab #PLOSBiology https://t.co/5CaR7ncQMB https://t.co/I6kphZ7q9K

Jun 14, 2023 · 8 likes · 1 share · 103,150 followers View post →
Medical Xpress
@medical_xpress · X

Key regulator of COVID viral receptor may be new drug target @plos https://t.co/3EWOy37juU https://t.co/jJU4wOaI5k

Jun 13, 2023 · 7 likes · 6 shares · 173,006 followers View post →
PLOS Biology
@PLOSBiology · X

The kinase DYRK1A can aid #coronavirus entry by driving #chromatin accessibility & active transcription at coronavirus receptor gene loci, independent of its catalytic function #SARSCoV2 #SARSCoV #MERSCoV @madisonstrine &co @WilenLab #PLOSBiology https://t.co/5CaR7ndoC9 https://t.co/MxKAoi6ceM

Jun 15, 2023 · 4 likes · 2 shares · 103,150 followers View post →
Konnikova lab
@LizaKonnikova · X

Fantastic new paper from ⁦@WilenLab⁩ and ⁦@madisonstrine⁩. Congrats to everyone. DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner | PLOS Biology https://t.co/kYKhxsoiZi

Jun 14, 2023 · 4 likes · 1,389 followers View post →
BWFUND
@BWFUND · X

From @PLOSBiology - DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner https://t.co/HCxMVMPYtK #bwfcams https://t.co/r9B3zt9Nt5

Jun 14, 2023 · 2 likes · 1 share · 7,117 followers View post →

All mentions

Tautaton
@tautaton · X

DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner https://t.co/1Cj6svdz2M

Aug 15, 2024 · 92 followers View post →
Woody Nist
@Woodynist · X

In summary, we report that DYRK1A is a novel regulator of ACE2 and DPP4 expression that may dictate susceptibility to multiple highly pathogenic human coronaviruses. https://t.co/WJJXSpBv8F

Sep 3, 2023 · 1,310 followers View post →
June_12_1776
@June_12_1776 · X

Part 121. DYRK1A promotes DNA accessibility at the ACE2 promoter and a putative distal enhancer, facilitating transcription and gene expression. #DYRK1A promotes #viralentry of highly pathogenic human coronaviruses in a kinase-independent manner https://t.co/PFP1LnoJ6O https://t.co/gxUxCe1V1n

Jul 13, 2023 · 6 followers View post →
Craig Wilen
@WilenLab · X

This along with our companion papers provides important insight into the epigenetic regulation of ACE2. If and how cBAF, Dyrk1a, and Kdm6a/Kmt2d interact to regulate ACE2 is an open question. https://t.co/yolEM6Yugc https://t.co/iySOqzs5EC

Jul 6, 2023 · 2 likes · 2,715 followers View post →
NP AGARWAL世界一フォローを目指しますAiming best in world.
@np_grwl · X

RT @medical_xpress: Key regulator of COVID viral receptor may be new drug target @plos https://t.co/3EWOy37juU https://t.co/jJU4wOaI5k

Jun 21, 2023 · 6 shares · 1,788 followers View post →
insom ne ya
@insom_ai333 · X

RT @PLOSBiology: The kinase DYRK1A can aid #coronavirus entry by driving #chromatin accessibility & active transcription at coronavirus rec…

Jun 15, 2023 · 2 shares · 1,955 followers View post →
PLOS Biology
@PLOSBiology · X

The kinase DYRK1A can aid #coronavirus entry by driving #chromatin accessibility & active transcription at coronavirus receptor gene loci, independent of its catalytic function #SARSCoV2 #SARSCoV #MERSCoV @madisonstrine &co @WilenLab #PLOSBiology https://t.co/5CaR7ndoC9 https://t.co/MxKAoi6ceM

Jun 15, 2023 · 4 likes · 2 shares · 103,150 followers View post →
Medical Science and Technology #earlytreatments
@MedicalScitech · X

RT @PLOSBiology: The kinase DYRK1A can aid #coronavirus entry by driving #chromatin accessibility & active transcription at coronavirus rec…

Jun 15, 2023 · 5 shares · 634 followers View post →
k.h3q
@090_0655 · X

RT @PLOSBiology: The kinase DYRK1A can aid #coronavirus entry by driving #chromatin accessibility & active transcription at coronavirus rec…

Jun 14, 2023 · 5 shares · 366 followers View post →
PLOS Biology
@PLOSBiology · X

RT @BWFUND: From @PLOSBiology - DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner https:/…

Jun 14, 2023 · 1 share · 103,150 followers View post →
BWFUND
@BWFUND · X

From @PLOSBiology - DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner https://t.co/HCxMVMPYtK #bwfcams https://t.co/r9B3zt9Nt5

Jun 14, 2023 · 2 likes · 1 share · 7,117 followers View post →
PLOS Biology
@PLOSBiology · X

The kinase DYRK1A can aid #coronavirus entry by driving #chromatin accessibility & active transcription at coronavirus receptor gene loci, independent of its catalytic function #SARSCoV2 #SARSCoV #MERSCoV @madisonstrine &co @WilenLab #PLOSBiology https://t.co/5CaR7ncQMB https://t.co/I6kphZ7q9K

Jun 14, 2023 · 8 likes · 1 share · 103,150 followers View post →
bostonjetcharter.com
@Gifted_udeh · X

RT @PLOSBiology: The kinase DYRK1A can aid #coronavirus entry by driving #chromatin accessibility & active transcription at coronavirus rec…

Jun 14, 2023 · 5 shares · 131 followers View post →
Konnikova lab
@LizaKonnikova · X

Fantastic new paper from ⁦@WilenLab⁩ and ⁦@madisonstrine⁩. Congrats to everyone. DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner | PLOS Biology https://t.co/kYKhxsoiZi

Jun 14, 2023 · 4 likes · 1,389 followers View post →
Edward Nirenberg
@ENirenberg · X

RT @PLOSBiology: The kinase DYRK1A can aid #coronavirus entry by driving #chromatin accessibility & active transcription at coronavirus rec…

Jun 14, 2023 · 5 shares · 33,517 followers View post →
PLOS Biology
@PLOSBiology · X

The kinase DYRK1A can aid #coronavirus entry by driving #chromatin accessibility & active transcription at coronavirus receptor gene loci, independent of its catalytic function #SARSCoV2 #SARSCoV #MERSCoV @madisonstrine &co @WilenLab #PLOSBiology https://t.co/5CaR7ndoC9 https://t.co/3IdoGi5GFj

Jun 14, 2023 · 9 likes · 5 shares · 103,150 followers View post →
Ordo Fraterna Fibonacci
@OrdoFibonacci · X

#PLOSBiology: DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent ma ... https://t.co/2EvlsMZ9nl

Jun 14, 2023 · 2,569 followers View post →
Phage Papers
@Phage_Papers · X

DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner https://t.co/BPGgF4gjYE

Jun 13, 2023 · 647 followers View post →
타로
@TopologistT · X

RT @medical_xpress: Key regulator of COVID viral receptor may be new drug target @plos https://t.co/3EWOy37juU https://t.co/jJU4wOaI5k

Jun 13, 2023 · 6 shares · 27 followers View post →
Sagittarius
@guani_vic · X

RT @medical_xpress: Key regulator of COVID viral receptor may be new drug target @plos https://t.co/3EWOy37juU https://t.co/jJU4wOaI5k

Jun 13, 2023 · 6 shares · 676 followers View post →
Medical Xpress
@physorg_health · X

RT @medical_xpress: Key regulator of COVID viral receptor may be new drug target @plos https://t.co/3EWOy37juU https://t.co/jJU4wOaI5k

Jun 13, 2023 · 6 shares · 7,103 followers View post →
Science X
@sciencex_com · X

RT @medical_xpress: Key regulator of COVID viral receptor may be new drug target @plos https://t.co/3EWOy37juU https://t.co/jJU4wOaI5k

Jun 13, 2023 · 6 shares · 3,529 followers View post →
Phys.org
@physorg_com · X

RT @medical_xpress: Key regulator of COVID viral receptor may be new drug target @plos https://t.co/3EWOy37juU https://t.co/jJU4wOaI5k

Jun 13, 2023 · 6 shares · 1,023,879 followers View post →
Medical Xpress
@medical_xpress · X

Key regulator of COVID viral receptor may be new drug target @plos https://t.co/3EWOy37juU https://t.co/jJU4wOaI5k

Jun 13, 2023 · 7 likes · 6 shares · 173,006 followers View post →