August 2023 PMID 37332089

Total Synthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites.

Péter Angyal, Kristóf Hegedüs, Bence Balázs Mészáros, János Daru, Ádám Dudás, Anna Rita Galambos, Nariman Essmat, Mahmoud Al-Khrasani, Szilárd Varga, Tibor Soós

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Mentions

36
Peak: 16 in Jul 2023
across 4 sources since Jun 2023

Extended reach

170,875
potential audience

Total likes

542

Video views

18,707

Mentions per month

Jun 2023 – Jul 2025

Where it's discussed

  • X / Twitter30 posts
  • Reddit3 posts
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

Overall, discussions around the publication display clear enthusiasm and recognition of its significance, highlighted by comments like 'Still making waves' and 'exciting news,' which emphasize the research's prominence. Tone and word choice suggest respect and admiration for the scientific achievement while primarily focusing on the publication's visibility and accolades rather than critical analysis or detailed scientific implications.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, with some indicating that the study 'makes waves' and 'is one of the most-viewed articles in the past year,' suggesting general support or recognition of its importance.

InterestHigh interest

There is evident curiosity and enthusiasm, as reflected by comments like 'this is so cool guys' and mentions of the research being 'exciting' and 'making waves,' showing high interest levels.

EngagementModerate engagement

The engagement is moderate; some posts celebrate the research's acceptance and prize awards, but there is limited detailed discussion or critique of the science itself, indicating surface-level engagement.

ImpactModerate impact

The perceived impact is modest; while some posts note the paper's popularity and recognition, there is little indication of discussions about the broader implications or potential changes in research or policy.

Abstract in brief

  • The study reports the first enantioselective and scalable total synthesis of mitragynine pseudoindoxyl, a kratom metabolite with fewer side effects compared to traditional opioids, using a novel cascade relay process without protecting groups.
  • Researchers found that mitragynine pseudoindoxyl doesn’t act as a single structure but exists as a mixture of stereoisomers in biological environments, showing structural flexibility that could influence its effects.
  • These findings lay the groundwork for designing new analogues of mitragynine pseudoindoxyl, which could lead to the development of improved pain-relief medications with better safety profiles.

Top posts

Most liked on X and Bluesky
NaOH Bartfield
@NaOHBartfield · X

this is so cool guys Total Synthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites (https://t.co/m6IyLBe4IH) https://t.co/zA6Z3rN7iQ

Jul 5, 2023 · 28 likes · 7,123 followers View post →
Soos OrgCat Lab
@SoosGroup · X

Exciting news! Our research paper on kratom metabolites is now accepted in @angew_chem! The total synthesis and the investigation of structural plasticity of these opioid analgesics in biological systems was a remarkable journey. Kudos to the team! https://t.co/5nXNJQLj6P

Jun 19, 2023 · 26 likes · 7 shares · 956 followers View post →
Angewandte Chemie
@angew_chem · X

#TotalSynthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites (Tibor Soos and co-workers) @SoosGroup #openaccess https://t.co/LRRzdadHBg

Jul 19, 2023 · 19 likes · 6 shares · 111,537 followers View post →
Soos OrgCat Lab
@SoosGroup · X

Congratulations Krisz & Peti on your well-deserved prizes at the Organic & Medicinal Chemistry Symposium by BUTE & Hungarian Chemical Society! A big congrats to the other team members for their contributions to the success! https://t.co/OpSuiMAb8H and https://t.co/KJuQsFdgHh https://t.co/uBOeq44bb0

Jul 3, 2023 · 13 likes · 3 shares · 956 followers View post →
That Chemist
@That_Chemist · X

Sauce https://t.co/JcPsPiaNRs

Jul 27, 2023 · 7 likes · 2 shares · 6,425 followers View post →
Soos OrgCat Lab
@SoosGroup · X

Still making waves: our @angew_chem paper “Total Synthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites” was one of the most-viewed articles in the past year!

Apr 16, 2025 · 7 likes · 1 share · 956 followers View post →

All mentions

Danny Benten ⚜️
@dreamr9876 · X

@HHSGov @RobertKennedyJr @CDCgov Please develop and ease access to treatments for the #fentanyl crisis and leave much less potent, less dangerous plants like #kratom alone. Don't allow it to become a CI restricted control substance. Respectfully https://t.co/2bUD19Akq2

Jul 30, 2025 · 1,621 followers View post →
Sóvári Bence
@BenceSovari · X

RT @SoosGroup: Still making waves: our @angew_chem paper “Total Synthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites” wa…

Apr 16, 2025 · 1 share · 40 followers View post →
Soos OrgCat Lab
@soosgroup.bsky.social · Bluesky

Still making waves: our @angewandtechemie.bsky.social paper “Total Synthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites” was one of the most-viewed articles in the past year!

Apr 16, 2025 · 3 likes View post →
Soos OrgCat Lab
@SoosGroup · X

Still making waves: our @angew_chem paper “Total Synthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites” was one of the most-viewed articles in the past year!

Apr 16, 2025 · 7 likes · 1 share · 956 followers View post →
Abstream
@abstreamme · X

Total Synthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites #science #publication #research #publications https://t.co/6whUlf6QbZ

Aug 24, 2023 · 789 followers View post →
VisualMod
@8bit_vivi · X

RT @That_Chemist: Sauce https://t.co/JcPsPiaNRs

Jul 27, 2023 · 2 shares · 189 followers View post →
That Chemist
@That_Chemist · X

Sauce https://t.co/JcPsPiaNRs

Jul 27, 2023 · 7 likes · 2 shares · 6,425 followers View post →
Vipin Rangari
@Vipin36590264 · X

RT @angew_chem: #TotalSynthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites (Tibor Soos and co-workers) @SoosGroup #opena…

Jul 19, 2023 · 6 shares · 47 followers View post →
Sóvári Bence
@BenceSovari · X

RT @angew_chem: #TotalSynthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites (Tibor Soos and co-workers) @SoosGroup #opena…

Jul 19, 2023 · 6 shares · 40 followers View post →
István Ujváry
@IUjvary · X

RT @angew_chem: #TotalSynthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites (Tibor Soos and co-workers) @SoosGroup #opena…

Jul 19, 2023 · 6 shares · 460 followers View post →
Soos OrgCat Lab
@SoosGroup · X

RT @angew_chem: #TotalSynthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites (Tibor Soos and co-workers) @SoosGroup #opena…

Jul 19, 2023 · 6 shares · 956 followers View post →
全合成たん
@chemiegg · X

RT @angew_chem: #TotalSynthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites (Tibor Soos and co-workers) @SoosGroup #opena…

Jul 19, 2023 · 6 shares · 2,473 followers View post →
Shenvi Lab
@Shenvi_Lab · X

RT @angew_chem: #TotalSynthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites (Tibor Soos and co-workers) @SoosGroup #opena…

Jul 19, 2023 · 6 shares · 7,026 followers View post →
Angewandte Chemie
@angew_chem · X

#TotalSynthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites (Tibor Soos and co-workers) @SoosGroup #openaccess https://t.co/LRRzdadHBg

Jul 19, 2023 · 19 likes · 6 shares · 111,537 followers View post →
LibKey
@libkey_io · X

@NaOHBartfield Paywalls are frustrating! Access the article from your library: https://t.co/KUfWAfm1Ub Promote scholarly access when tweeting articles by simply adding https://t.co/SXSePSX5De to the DOI URL

Jul 5, 2023 · 555 followers View post →
NaOH Bartfield
@NaOHBartfield · X

this is so cool guys Total Synthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites (https://t.co/m6IyLBe4IH) https://t.co/zA6Z3rN7iQ

Jul 5, 2023 · 28 likes · 7,123 followers View post →
Péter J. Mayer
@Wengivis · X

RT @SoosGroup: Congratulations Krisz & Peti on your well-deserved prizes at the Organic & Medicinal Chemistry Symposium by BUTE & Hungarian…

Jul 4, 2023 · 3 shares · 81 followers View post →
Kotschy András
@kotschyandras · X

RT @SoosGroup: Congratulations Krisz & Peti on your well-deserved prizes at the Organic & Medicinal Chemistry Symposium by BUTE & Hungarian…

Jul 3, 2023 · 3 shares · 37 followers View post →
Sóvári Bence
@BenceSovari · X

RT @SoosGroup: Congratulations Krisz & Peti on your well-deserved prizes at the Organic & Medicinal Chemistry Symposium by BUTE & Hungarian…

Jul 3, 2023 · 3 shares · 40 followers View post →
Soos OrgCat Lab
@SoosGroup · X

Congratulations Krisz & Peti on your well-deserved prizes at the Organic & Medicinal Chemistry Symposium by BUTE & Hungarian Chemical Society! A big congrats to the other team members for their contributions to the success! https://t.co/OpSuiMAb8H and https://t.co/KJuQsFdgHh https://t.co/uBOeq44bb0

Jul 3, 2023 · 13 likes · 3 shares · 956 followers View post →
István Ujváry
@IUjvary · X

Total synthesis and structural plasticity of kratom pseudoindoxyl metabolites https://t.co/0Tu4OLZtsR

Jul 1, 2023 · 2 likes · 460 followers View post →
Mike Cunningham
@thewatchglass · X

Beautiful SI

Jun 29, 2023 · 1,000 followers View post →
Life Science Journal Content
@lsn_jc · X

Total Synthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites #science #publication #research #journal https://t.co/N6Yr30npc3

Jun 22, 2023 · 263 followers View post →
Shenvi Lab
@Shenvi_Lab · X

RT @SoosGroup: Exciting news! Our research paper on kratom metabolites is now accepted in @angew_chem! The total synthesis and the investig…

Jun 19, 2023 · 7 shares · 7,026 followers View post →
Burgerking
@GLcool54 · X

RT @SoosGroup: Exciting news! Our research paper on kratom metabolites is now accepted in @angew_chem! The total synthesis and the investig…

Jun 19, 2023 · 7 shares · 38 followers View post →
Functional Organic Materials Research Group, RCNS
@OrgMatHun · X

RT @SoosGroup: Exciting news! Our research paper on kratom metabolites is now accepted in @angew_chem! The total synthesis and the investig…

Jun 19, 2023 · 7 shares · 490 followers View post →
Péter J. Mayer
@Wengivis · X

RT @SoosGroup: Exciting news! Our research paper on kratom metabolites is now accepted in @angew_chem! The total synthesis and the investig…

Jun 19, 2023 · 7 shares · 81 followers View post →
Kele_Lab (Chem. Biol. Res. Group)
@ChemBiolHun · X

RT @SoosGroup: Exciting news! Our research paper on kratom metabolites is now accepted in @angew_chem! The total synthesis and the investig…

Jun 19, 2023 · 7 shares · 195 followers View post →
Sóvári Bence
@BenceSovari · X

RT @SoosGroup: Exciting news! Our research paper on kratom metabolites is now accepted in @angew_chem! The total synthesis and the investig…

Jun 19, 2023 · 7 shares · 40 followers View post →
Kotschy András
@kotschyandras · X

RT @SoosGroup: Exciting news! Our research paper on kratom metabolites is now accepted in @angew_chem! The total synthesis and the investig…

Jun 19, 2023 · 7 shares · 37 followers View post →
Soos OrgCat Lab
@SoosGroup · X

Exciting news! Our research paper on kratom metabolites is now accepted in @angew_chem! The total synthesis and the investigation of structural plasticity of these opioid analgesics in biological systems was a remarkable journey. Kudos to the team! https://t.co/5nXNJQLj6P

Jun 19, 2023 · 26 likes · 7 shares · 956 followers View post →