Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations.

Katya Ahmad, Abid Javed, Conor Lanphere, Peter V Coveney, Elena V Orlova, Stefan Howorka

June 2023 Nat Commun

Synopsis of Social media discussions

The overall reactions show appreciation for the detailed structural analysis, with mentions of how the study 'reveals shape changes in different environments' and implications for biosensing, indicating a moderate level of interest and impact. Words like 'new', 'significant', and references to the use of cryo-EM and simulations suggest an acknowledgment of the research's importance, although there is limited evidence of deep technical discussion.

A
Agreement
 Moderate agreement

Most discussions accept the findings as significant, especially highlighting the detailed structural insights and implications for future research.

I
Interest
 Moderate level of interest

Posts express moderate curiosity, noting the innovative methods used and potential applications in biosensing and nanotechnology.

E
Engagement
 Neutral engagement

Conversations are somewhat surface-level, mainly sharing links and headlines without deep technical debate.

I
Impact
 Moderate level of impact

Participants recognize the study’s importance, noting its relevance for nanostructure design and biological applications.

Social Mentions

YouTube

1 Videos

Twitter

10 Posts

Metrics

Video Views

36

Total Likes

9

Extended Reach

15,351

Social Features

11

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

DNA Nanoarchitecture Structure and Dynamics Revealed by Cryo-EM and Simulations

DNA Nanoarchitecture Structure and Dynamics Revealed by Cryo-EM and Simulations

This study uses cryo-electron microscopy and molecular dynamics simulations to explore the structure and behavior of a specific DNA nanoarchitecture, revealing how its shape changes in different environments like solvents and biological membranes. The stability depends on salt concentration, informing future biosensing and

STEM RTCL TV

September 21, 2023

36 views

  • Tanner Lab HKU
    @tanner_jnl_club (Twitter)

    Simon: Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations https://t.co/luTbFmawGb
    view full post

    October 24, 2023

  • UCL Discovery
    @ucl_discovery (Twitter)

    Open Access UCL Research: Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations MessageStatus of item chang https://t.co/qfQMfu3EhX
    view full post

    June 30, 2023

  • CRISPR GLENN
    @CrisprGlenn (Twitter)

    RT @DNA_Nanotech: Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations http…
    view full post

    June 23, 2023

    3

  • Paul Lourdu Xavier
    @PaulLXavier (Twitter)

    RT @DNA_Nanotech: Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations http…
    view full post

    June 23, 2023

    3

  • J. Fernando Bazan @jfernandobazan.bsky.social
    @jfernandobazan (Twitter)

    RT @DNA_Nanotech: Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations http…
    view full post

    June 23, 2023

    3

  • Yoel Ohayon
    @DNA_Nanotech (Twitter)

    Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations https://t.co/sxpwRLkRbg The six-duplex bundle is arranged in non-hexagonal fashion and is disorted to form a wider, less elongated structure. https://t.co/9WJA84rB3d
    view full post

    June 22, 2023

    8

    3

  • Europe PMC articles
    @EuropePMC (Twitter)

    New from #wellcometrust https://t.co/PFrT4sABFp Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations.
    view full post

    June 21, 2023

  • Europe PMC articles
    @EuropePMC (Twitter)

    New from #BBSRC https://t.co/PFrT4sABFp Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations.
    view full post

    June 21, 2023

  • Jeanne Bark
    @marc_herb (Twitter)

    @NatureComms @howorka_lab Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations https://t.co/aJv9RjJVue
    view full post

    June 20, 2023

    1

  • LUKMAN AFOLABI
    @saintlukman (Twitter)

    Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations https://t.co/ECpDUaj1kC https://t.co/4x5E0YrMMs
    view full post

    June 19, 2023

Abstract Synopsis

  • This study uses cryo-electron microscopy and molecular dynamics simulations to explore the structure and behavior of a specific DNA nanoarchitecture, revealing how its shape changes in different environments like solvents and biological membranes.
  • Without lipid membranes, the DNA structure doesn't maintain its intended symmetrical shape and appears more disorganized, but inserting into lipid membranes restores the designed barrel shape due to compression effects from the membrane.
  • The stability of this DNA nanopore is heavily influenced by salt concentration, which affects the electrostatic interactions between the negatively charged DNA strands, offering insights useful for future design and biosensing applications.