Nat Commun June 2023 PMID 37336895

Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations.

Katya Ahmad, Abid Javed, Conor Lanphere, Peter V Coveney, Elena V Orlova, Stefan Howorka

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Mentions

11
Peak: 9 in Jun 2023
across 2 sources since Jun 2023

Extended reach

15,351
potential audience

Total likes

9

Video views

36

Mentions per month

Jun 2023 – Oct 2023

Where it's discussed

  • X / Twitter10 posts
  • YouTube1 videos

AI synopsis

What people are saying

The overall reactions show appreciation for the detailed structural analysis, with mentions of how the study 'reveals shape changes in different environments' and implications for biosensing, indicating a moderate level of interest and impact. Words like 'new', 'significant', and references to the use of cryo-EM and simulations suggest an acknowledgment of the research's importance, although there is limited evidence of deep technical discussion.

AgreementModerate agreement

Most discussions accept the findings as significant, especially highlighting the detailed structural insights and implications for future research.

InterestModerate interest

Posts express moderate curiosity, noting the innovative methods used and potential applications in biosensing and nanotechnology.

EngagementNeutral engagement

Conversations are somewhat surface-level, mainly sharing links and headlines without deep technical debate.

ImpactModerate impact

Participants recognize the study’s importance, noting its relevance for nanostructure design and biological applications.

Abstract in brief

  • This study uses cryo-electron microscopy and molecular dynamics simulations to explore the structure and behavior of a specific DNA nanoarchitecture, revealing how its shape changes in different environments like solvents and biological membranes.
  • Without lipid membranes, the DNA structure doesn't maintain its intended symmetrical shape and appears more disorganized, but inserting into lipid membranes restores the designed barrel shape due to compression effects from the membrane.
  • The stability of this DNA nanopore is heavily influenced by salt concentration, which affects the electrostatic interactions between the negatively charged DNA strands, offering insights useful for future design and biosensing applications.

Top posts

Most liked on X and Bluesky
Yoel Ohayon
@DNA_Nanotech · X

Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations https://t.co/sxpwRLkRbg The six-duplex bundle is arranged in non-hexagonal fashion and is disorted to form a wider, less elongated structure. https://t.co/9WJA84rB3d

Jun 22, 2023 · 8 likes · 3 shares · 3,445 followers View post →
Jeanne Bark
@marc_herb · X

@NatureComms @howorka_lab Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations https://t.co/aJv9RjJVue

Jun 20, 2023 · 1 like · 644 followers View post →
CRISPR GLENN
@CrisprGlenn · X

RT @DNA_Nanotech: Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations http…

Jun 23, 2023 · 3 shares · 2,648 followers View post →
UCL Discovery
@ucl_discovery · X

Open Access UCL Research: Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations MessageStatus of item chang https://t.co/qfQMfu3EhX

Jun 30, 2023 · 2,526 followers View post →
Europe PMC articles
@EuropePMC · X

New from #BBSRC https://t.co/PFrT4sABFp Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations.

Jun 21, 2023 · 1,552 followers View post →
Europe PMC articles
@EuropePMC · X

New from #wellcometrust https://t.co/PFrT4sABFp Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations.

Jun 21, 2023 · 1,552 followers View post →

All mentions

Tanner Lab HKU
@tanner_jnl_club · X

Simon: Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations https://t.co/luTbFmawGb

Oct 24, 2023 · 122 followers View post →
UCL Discovery
@ucl_discovery · X

Open Access UCL Research: Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations MessageStatus of item chang https://t.co/qfQMfu3EhX

Jun 30, 2023 · 2,526 followers View post →
CRISPR GLENN
@CrisprGlenn · X

RT @DNA_Nanotech: Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations http…

Jun 23, 2023 · 3 shares · 2,648 followers View post →
Paul Lourdu Xavier
@PaulLXavier · X

RT @DNA_Nanotech: Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations http…

Jun 23, 2023 · 3 shares · 1,175 followers View post →
J. Fernando Bazan @jfernandobazan.bsky.social
@jfernandobazan · X

RT @DNA_Nanotech: Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations http…

Jun 23, 2023 · 3 shares · 705 followers View post →
Yoel Ohayon
@DNA_Nanotech · X

Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations https://t.co/sxpwRLkRbg The six-duplex bundle is arranged in non-hexagonal fashion and is disorted to form a wider, less elongated structure. https://t.co/9WJA84rB3d

Jun 22, 2023 · 8 likes · 3 shares · 3,445 followers View post →
Europe PMC articles
@EuropePMC · X

New from #wellcometrust https://t.co/PFrT4sABFp Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations.

Jun 21, 2023 · 1,552 followers View post →
Europe PMC articles
@EuropePMC · X

New from #BBSRC https://t.co/PFrT4sABFp Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations.

Jun 21, 2023 · 1,552 followers View post →
Jeanne Bark
@marc_herb · X

@NatureComms @howorka_lab Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations https://t.co/aJv9RjJVue

Jun 20, 2023 · 1 like · 644 followers View post →
LUKMAN AFOLABI
@saintlukman · X

Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations https://t.co/ECpDUaj1kC https://t.co/4x5E0YrMMs

Jun 19, 2023 · 922 followers View post →