Front Endocrinol (Lausanne) July 2023 PMID 37404310

Structural insights into the HNF4 biology.

Brice Beinsteiner, Isabelle M L Billas, Dino Moras

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Peak: 2 in Jun 2023

across 2 sources since Jun 2023

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9,165

potential audience

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Jun 2023 – Oct 2023

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YouTube1 videos

AI synopsis

What people are saying

The overall tone reflects a recognition of the significance of the structural understanding of HNF4, with posts focusing on its role in gene regulation and disease. Phrases like 'new research' and mentions of HNF4's functions imply curiosity and acknowledgment of its importance, while references to specific organs and disease links demonstrate some engagement with the research's broader implications.

AgreementModerate agreement

Most discussions align with the importance of the research, recognizing HNF4's role in gene regulation and disease relevance.

InterestModerate interest

Posts show a moderate level of curiosity, highlighting the structural aspects and disease implications without deep technical analysis.

EngagementModerate engagement

Comments reference structural details and potential applications, indicating some thoughtful engagement, but lack extensive debates or personal insights.

ImpactModerate impact

The discussions suggest the research could influence future studies in endocrinology and medicine, though they remain at an introductory level of impact.

Abstract in brief

HNF4 is a transcription factor in the nuclear receptor family that plays a key role in regulating genes related to lipid transport and glucose metabolism in organs like the liver, kidney, intestine, and pancreas, and is essential for cellular development.
The review discusses the structural aspects of HNF4, focusing on its DNA binding domain (DBD), ligand binding domain (LBD), and the entire receptor, comparing these structures with other nuclear receptors to understand their function and the impact of mutations.
It emphasizes how structural changes caused by mutations or modifications can influence HNF4’s function, which is important because dysregulation is linked to human diseases such as diabetes type I (MODY1) and hemophilia.]

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All mentions

Structural Insights into HNF4 Biology and Its Role in Disease Mechanisms

This video explores the structural features of HNF4, a nuclear receptor transcription factor crucial for lipid, glucose metabolism, and cellular development. Understanding these structures helps reveal how mutations…

Social RTCL TV · Oct 7, 2023 29 views

TF binding papers

@TF_binding_bot · X

Structural insights into the HNF4 biology https://t.co/Jjo9kY7prL

Jul 5, 2023 · 3,774 followers View post →

DrMadan11

@DrMadan11 · X

RT @FrontEndocrinol: New Research: Structural insights into the HNF4 biology: Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor…

Jun 19, 2023 · 1 share · 309 followers View post →

Frontiers - Endocrinology

@FrontEndocrinol · X

Jun 19, 2023 · 2 likes · 1 share · 5,050 followers View post →