Mol Cancer Res November 2023 PMID 37409952

Updating the Definition of Cancer.

Joel S Brown, Sarah R Amend, Robert H Austin, Robert A Gatenby, Emma U Hammarlund, Kenneth J Pienta

Mentions

23
Peak: 8 in Jul 2023
across 4 sources since Jul 2023

Extended reach

31,414
potential audience

Total likes

50

Video views

521

Mentions per month

Jul 2023 – Dec 2025

Where it's discussed

  • X / Twitter17 posts
  • News3 articles
  • YouTube2 videos
  • LinkedIn1 posts

AI synopsis

What people are saying

Overall, discussions display curiosity about the new cancer definition, highlighted by references to scientific sources and debates over terminology and implications, such as the suggestion that the updated definition incorporates natural selection as a key concept. The tone varies from skeptical comments dismissing the content as simplistic to more detailed mentions of evolutionary principles, reflecting diverse levels of engagement and perception of impact.

AgreementNeither agree nor disagree

The discussions show mixed opinions; some recognize the importance of the new definition, while others claim it lacks alignment with scientific terminology or dismiss it as oversimplified.

InterestModerate interest

Participants demonstrate moderate interest by engaging with various perspectives and background sources, but some dismiss the topic as superficial or confusing.

EngagementModerate engagement

Many comments reference specific parts of the publication or related scientific discussions, indicating active engagement.

ImpactModerate impact

The exchanges reflect an awareness of the evolving understanding of cancer, with some suggesting policy or scientific implications, though not uniformly emphasizing major changes.

Abstract in brief

  • The current common definitions of cancer describe it as uncontrolled cell growth that spreads, but they don't fully explain how cancer cells themselves become transformed and evolve over time.
  • The proposed new definition describes cancer as a disease caused by transformed (changed) cells that grow uncontrollably and are subject to natural selection, meaning they evolve through genetic and epigenetic changes.
  • This updated definition aims to better reflect modern understanding by emphasizing that cancer involves not just uncontrolled growth, but also transformation and ongoing evolution of cancer cells, which contribute to their ability to metastasize and become lethal.]

Top posts

Most liked on X and Bluesky
Jeffrey West
@mathoncbro · X

"...our proposed definition then adds 'subject to evolution by natural selection.'" https://t.co/yWaKIld9dV https://t.co/yPE9YIxntY

Jul 11, 2023 · 24 likes · 6 shares · 8,924 followers View post →
The Gatenby Lab
@GatenbyLab · X

Updating the Definition of Cancer https://t.co/7GzukzLRw6

Nov 9, 2023 · 3 likes · 1 share · 229 followers View post →
Molecular Cancer Research
@MCR_AACR · X

From the November issue— Updating the Definition of Cancer, by Brown et al. https://t.co/VxVE7yzYx7 @MoffittNews https://t.co/AOvHLXmpUP

Nov 6, 2023 · 1 like · 2,300 followers View post →
Molecular Cancer Research
@MCR_AACR · X

From the latest issue— Updating the Definition of Cancer, by Brown et al. https://t.co/2majeb91Km @MoffittNews https://t.co/cXIiIw5wFQ

Nov 20, 2023 · 1 like · 2,300 followers View post →
Jeremy Kratz
@JeremyKratz · X

New definition of cancer that takes the mystery out of cumulative mutations to explain how cancer cell population evolve by predictable evolutionary principles. https://t.co/NL5pMfF2hN

Jul 20, 2023 · 1 like · 416 followers View post →
Sandy Anderson
@ara_anderson · X

RT @mathoncbro: "...our proposed definition then adds 'subject to evolution by natural selection.'" https://t.co/yWaKIld9dV https://t.co/y…

Jul 11, 2023 · 6 shares · 5,421 followers View post →

All mentions

ci2twit
@ci2twit · X

@JoeSixPackShow @sethweathers A "science link"? OK boomer. Dr. Califano’s statement in Columbia Magazine is used euphemistically in an entertainment piece for a likely lay audience. It does not align with scientific nomenclature. https://t.co/Z35fWnten2 https://t.co/57Eblzu8CJ https://t.co/ispWkLYl7v

Aug 4, 2025 · 834 followers View post →
Molecular Cancer Research
@MCR_AACR · X

Don't miss this @MCR_AACR perspective coauthored by Joel Brown and @sr_amend, session speakers at tomorrow's #AACR25 Educational Session on the Ecology of Cancer: https://t.co/FQcafoRmUe #OpenAccess https://t.co/xs9qgXn1WE

Apr 25, 2025 · 2,300 followers View post →
70% H2O Neuro
@jotaped · X

@GArrendatario @lunaenllamas Aquí puede encontrar las bases científicas que definen al cáncer. https://t.co/0LkrOL8DhY

Oct 15, 2024 · 602 followers View post →
Gates of Fauction
@BoJidenJr · X

How’s that Cancer Moonshot going for Bo Jiden & Dr JillBo Jiden? They must’ve misunderstood what was written for them in that speech bc otherwise we’d have to say they’re failing miserably I’m sure the FDA & CDC will updating the definition of cancer soon enough

Apr 8, 2024 · 357 followers View post →
Molecular Cancer Research
@MCR_AACR · X

From the latest issue— Updating the Definition of Cancer, by Brown et al. https://t.co/2majeb91Km @MoffittNews https://t.co/cXIiIw5wFQ

Nov 20, 2023 · 1 like · 2,300 followers View post →
The Gatenby Lab
@GatenbyLab · X

RT @GatenbyLab: Updating the Definition of Cancer https://t.co/7GzukzLRw6

Nov 15, 2023 · 1 share · 229 followers View post →
The Gatenby Lab
@GatenbyLab · X

Updating the Definition of Cancer https://t.co/7GzukzLRw6

Nov 9, 2023 · 3 likes · 1 share · 229 followers View post →
Molecular Cancer Research
@MCR_AACR · X

From the November issue— Updating the Definition of Cancer, by Brown et al. https://t.co/VxVE7yzYx7 @MoffittNews https://t.co/AOvHLXmpUP

Nov 6, 2023 · 1 like · 2,300 followers View post →
Jeffrey Townsend
@JeffTownsend · X

RT @mathoncbro: "...our proposed definition then adds 'subject to evolution by natural selection.'" https://t.co/yWaKIld9dV https://t.co/y…

Aug 24, 2023 · 6 shares · 2,424 followers View post →
Bryan Neth, MD, PhD
@bryanneth · X

Updating the Definition of Cancer | Molecular Cancer Research | American Association for Cancer Research https://t.co/1XJNQDflad

Jul 23, 2023 · 873 followers View post →
Jeremy Kratz
@JeremyKratz · X

New definition of cancer that takes the mystery out of cumulative mutations to explain how cancer cell population evolve by predictable evolutionary principles. https://t.co/NL5pMfF2hN

Jul 20, 2023 · 1 like · 416 followers View post →
Natalie Andersson
@NKAndersson · X

RT @mathoncbro: "...our proposed definition then adds 'subject to evolution by natural selection.'" https://t.co/yWaKIld9dV https://t.co/y…

Jul 11, 2023 · 6 shares · 76 followers View post →
Noemi Andor
@EinsteinCross · X

RT @mathoncbro: "...our proposed definition then adds 'subject to evolution by natural selection.'" https://t.co/yWaKIld9dV https://t.co/y…

Jul 11, 2023 · 6 shares · 581 followers View post →
Oliver Lopez-Corona (Tecozcacuauhtli)
@otrasenda_AC · X

RT @mathoncbro: "...our proposed definition then adds 'subject to evolution by natural selection.'" https://t.co/yWaKIld9dV https://t.co/y…

Jul 11, 2023 · 6 shares · 2,097 followers View post →
Thomas Veith
@thomasaveith · X

RT @mathoncbro: "...our proposed definition then adds 'subject to evolution by natural selection.'" https://t.co/yWaKIld9dV https://t.co/y…

Jul 11, 2023 · 6 shares · 803 followers View post →
Sandy Anderson
@ara_anderson · X

RT @mathoncbro: "...our proposed definition then adds 'subject to evolution by natural selection.'" https://t.co/yWaKIld9dV https://t.co/y…

Jul 11, 2023 · 6 shares · 5,421 followers View post →
Jeffrey West
@mathoncbro · X

"...our proposed definition then adds 'subject to evolution by natural selection.'" https://t.co/yWaKIld9dV https://t.co/yPE9YIxntY

Jul 11, 2023 · 24 likes · 6 shares · 8,924 followers View post →
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