ATPase activity of DFCP1 controls selective autophagy.

Viola Nähse, Camilla Raiborg, Kia Wee Tan, Sissel Mørk, Maria Lyngaas Torgersen, Eva Maria Wenzel, Mireia Nager, Veijo T Salo, Terje Johansen, Elina Ikonen, Kay Oliver Schink, Harald Stenmark

July 2023 Nat Commun

Synopsis of Social media discussions

The discussions use neutral language, often sharing the article title and highlighting its focus, such as 'ATPase activity of DFCP1 controls selective autophagy,' which shows recognition of its significance. The tone remains informational, with phrases indicating curiosity, like 'interesting role in autophagy,' but relatively few comments extend beyond acknowledgement, reflecting moderate interest and engagement.

A
Agreement
 Moderate agreement

Most discussions acknowledge the importance of the research, with some emphasizing the role of DFCP1 in autophagy while others show mild skepticism about its broader implications.

I
Interest
 Moderate level of interest

The discussions reflect moderate interest, highlighting curiosity about how ATPase activity influences selective autophagy without expressing deep enthusiasm or disinterest.

E
Engagement
 Moderate level of engagement

Participants reference the publication and share basic reactions, indicating a moderate level of engagement, but few delve into detailed analysis or critique.

I
Impact
 Moderate level of impact

The posts suggest that the research is seen as potentially impactful within the field, though it hasn't sparked widespread discussion on practical applications.

Social Mentions

YouTube

1 Videos

Twitter

4 Posts

Metrics

Video Views

26

Total Likes

3

Extended Reach

146,756

Social Features

5

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Role of ATPase Activity of DFCP1 in Facilitating Selective Autophagy

Role of ATPase Activity of DFCP1 in Facilitating Selective Autophagy

DFCP1 is an ATPase essential for maintaining selective autophagy by aiding omegasome constriction, which facilitates the release of autophagosomes necessary for degrading damaged components like mitochondria and protein aggregates.

STEM RTCL TV

October 20, 2023

26 views

  • Jeanne Bark
    @marc_herb (Twitter)

    @NatureComms https://t.co/Qdwk9zHNYm ATPase activity of DFCP1 controls selective autophagy
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    July 10, 2023

  • Ankit Singla
    @In_AnkitSingla (Twitter)

    RT @biorxivpreprint: ATPase activity of DFCP1 controls selective autophagy https://t.co/CW4nPINPcZ #bioRxiv
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    February 24, 2022

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  • bioRxiv Cell Biology
    @biorxiv_cellbio (Twitter)

    ATPase activity of DFCP1 controls selective autophagy https://t.co/Y5SkKZAlck #biorxiv_cellbio
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    February 24, 2022

  • bioRxiv
    @biorxivpreprint (Twitter)

    ATPase activity of DFCP1 controls selective autophagy https://t.co/CW4nPINPcZ #bioRxiv
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    February 24, 2022

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Abstract Synopsis

  • DFCP1 is an ATPase that binds and hydrolyzes ATP, which is essential for maintaining selective autophagy, especially for the degradation of specific damaged components.
  • The study shows that DFCP1's activity helps omegasomes (special ER regions where autophagosomes form) constrict properly, facilitating the release of autophagosomes necessary for selective autophagy processes like mitophagy and aggrephagy.
  • While DFCP1 isn't crucial for bulk autophagy, its ability to control omegasome constriction is vital for the selective autophagy pathway, highlighting its role in cellular cleanup and maintaining cellular health.]