Nat Commun July 2023 PMID 37422481

ATPase activity of DFCP1 controls selective autophagy.

Viola Nähse, Camilla Raiborg, Kia Wee Tan, Sissel Mørk, Maria Lyngaas Torgersen, Eva Maria Wenzel, Mireia Nager, Veijo T Salo, Terje Johansen, Elina Ikonen, Kay Oliver Schink, Harald Stenmark

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Mentions

Peak: 3 in Feb 2022

across 2 sources since Feb 2022

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146,756

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Feb 2022 – Oct 2023

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What people are saying

The discussions use neutral language, often sharing the article title and highlighting its focus, such as 'ATPase activity of DFCP1 controls selective autophagy,' which shows recognition of its significance. The tone remains informational, with phrases indicating curiosity, like 'interesting role in autophagy,' but relatively few comments extend beyond acknowledgement, reflecting moderate interest and engagement.

AgreementModerate agreement

Most discussions acknowledge the importance of the research, with some emphasizing the role of DFCP1 in autophagy while others show mild skepticism about its broader implications.

InterestModerate interest

The discussions reflect moderate interest, highlighting curiosity about how ATPase activity influences selective autophagy without expressing deep enthusiasm or disinterest.

EngagementModerate engagement

Participants reference the publication and share basic reactions, indicating a moderate level of engagement, but few delve into detailed analysis or critique.

ImpactModerate impact

The posts suggest that the research is seen as potentially impactful within the field, though it hasn't sparked widespread discussion on practical applications.

Abstract in brief

DFCP1 is an ATPase that binds and hydrolyzes ATP, which is essential for maintaining selective autophagy, especially for the degradation of specific damaged components.
The study shows that DFCP1's activity helps omegasomes (special ER regions where autophagosomes form) constrict properly, facilitating the release of autophagosomes necessary for selective autophagy processes like mitophagy and aggrephagy.
While DFCP1 isn't crucial for bulk autophagy, its ability to control omegasome constriction is vital for the selective autophagy pathway, highlighting its role in cellular cleanup and maintaining cellular health.]

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All mentions

Role of ATPase Activity of DFCP1 in Facilitating Selective Autophagy

DFCP1 is an ATPase essential for maintaining selective autophagy by aiding omegasome constriction, which facilitates the release of autophagosomes necessary for degrading damaged components like mitochondria and protein…

STEM RTCL TV · Oct 20, 2023 26 views

Jeanne Bark

@marc_herb · X

@NatureComms https://t.co/Qdwk9zHNYm ATPase activity of DFCP1 controls selective autophagy

Jul 10, 2023 · 644 followers View post →

Ankit Singla

@In_AnkitSingla · X

RT @biorxivpreprint: ATPase activity of DFCP1 controls selective autophagy https://t.co/CW4nPINPcZ #bioRxiv

Feb 24, 2022 · 1 share · 1,482 followers View post →

bioRxiv Cell Biology

@biorxiv_cellbio · X

ATPase activity of DFCP1 controls selective autophagy https://t.co/Y5SkKZAlck #biorxiv_cellbio

Feb 24, 2022 · 7,646 followers View post →

bioRxiv

@biorxivpreprint · X

ATPase activity of DFCP1 controls selective autophagy https://t.co/CW4nPINPcZ #bioRxiv

Feb 24, 2022 · 2 likes · 1 share · 136,955 followers View post →